14th ICID - Poster Abstracts - International Society for Infectious ...

More documents

Recommendations

Info

When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 28.028 Session: Influenza Date: Wednesday, March 10, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Factors associated to death in patients with confirmed diagnosis for influenza A/H1N1. State of Sao Paulo, Brazil, April to October, 2009 A. Ribeiro, A. C. G. Pellini, T. R. M. P. Carvalhanas, B. D. L. Liphaus, A. L. F. L. F. Yu, G. D. Freitas, M. D. C. S. T. Timenetsky State Secretary of Health of Sao Paulo, Sao Paulo, SP, Brazil Background: In April, 2009, a new subtype of influenza A/H1N1 virus emerged from the American continent, spreading worldwide. Until the end of October, 2009, WHO reported more than 440.000 influenza A/H1N1 laboratory-confirmed cases, registering more than 5.700 deaths. Studies point out that population groups who develop higher severity and mortality are: children less than two years of age, young adults, patients with chronic diseases and pregnant women. Methods: An exploratory analysis was performed to identify factors associated with death among confirmed cases of influenza A/H1N1, considering the residents and other people treated in healthcare facilities in SP, from EW 16 to 41. Data were collected from the Information System of Notifiable Hazards – Influenza Online. Association between remarkable expositions and death caused by influenza A/H1N1 was investigated by unadjusted odds ratio estimation, with 95% confidence intervals, employing the EpiInfo software. Results: In SP, since EW 16, 31.589 influenza A/H1N1 suspected cases were reported, from which 5.242 (16,6%) were confirmed and fulfilled the criteria for Severe Acute Respiratory Disease. Among these, 372 cases resulted in death, 3.619 were discharged from hospital and 1.251 are still under investigation. The following variables showed association with death caused by influenza A/H1N1: chronic cardiopathy OR=3,00 (IC95%=2,05-4,40); chronic renal failure OR=3,85 (IC95%=2,02-7,33); immunosuppression OR=4,93 (IC95%=3,35–7,25); tobacco abuse OR=1,52 (IC95%=1,03-2,26); chronic metabolic disease OR=6,36 (IC95%=4,27–9,48); diarrhea OR=1,56 (IC95%=1,16-2,10); ); residence in the metropolitan area of Greater Sao Paulo in relation to the interior of state OR=1,37 (IC95%=1,11-1,70). Variables which did not present association with death were: lack of previous vaccination against influenza OR=1,65 (IC95%=0,93-2,93) or pneumococcus OR=1,22 (IC95%=0,44-3,39); chronic pneumopathy OR=1,14 (IC95%=0,80-1,61); haemoglobinopathy OR=1,74 (IC95%=0,60-5,04). Conclusion: Widespread knowledge of influenza A/H1N1 epidemiology, its complications and risk factors for death is extremely important to support the implementation of strategies to prevent and control this disease in high-risk groups. Comparison of data found in the assessed population with other similar studies is recommended.
When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 28.029 Session: Influenza Date: Wednesday, March 10, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation H1N1 Epidemic: Our experience at PGIMER Delhi, India A. yadav, T. samra, M. pawar Dr.RML Hospital,PGIMER , New Delhi, India Background: Patients infected with the H1N1 strain of the influenza A virus frequently develop rapidly progressive lower respiratory tract disease resulting in respiratory failure. We describe the clinical characteristics of patients who expired in ICU at our hospital in Delhi, India. We did the study to see cause and pattern of death in H1N1. Methods: Using guidelines developed by the Indian health ministry, all individuals with flu-like symptoms were screened by a physician into three management categories- Category A (outpatient treatment and home isolation), Category B (hospital isolation ward) and Category C (intensive care units) based on clinical presentation. Of the 236 patients with confirmed H1N1 evaluated between 8th August to 27th October 2009 at our facility, 26 patients expired. Data was collected from the hospital records for patients with H1N1, who expired in the ICU. Influenza A (H1N1) virus infection was confirmed in specimens using TaqMan real-time reverse transcriptasepolymerase-chain-reaction (CDC Protocol). Results: Median age was 29 years (Range: 12 - 74); >80% of patients were < 40 years. Three (11.5%) were diabetic, 2 (7. 7%) pregnant, 5(19.2%) hypertensive, 2(7. 7%) had pre-existing respiratory disease and 14 (53.9%) had no pre-existing medical conditions. 24 (92.3%) had primary viral pneumonitis and 2 (7.7%) had exacerbation of structural respiratory disease. 14 (53.9%) developed acute respiratory distress syndrome (ARDS), 4(15.4%) developed multi organ dysfunction syndrome (MODS), 3 (11.5%) developed acute renal failure (ARF), 2(7.7%) developed myocarditis/Congestive heart failure (CHF) and 3(11.5%) developed disseminated intravascular coagulopathy (DIC).All 26 required mechanical ventilation. Oseltamivir administration delay ranged from 3 to 10 days after illness onset, 52.78% received high-dose (300mg/day) treatment, and treatment duration ranged from 1 to 10 days (mean 3.0 ± 2.5days). Conclusion: Over a 12 week period, H1N1 virus infection caused ICU deaths in 26 adult patients with a high case fatality rate of 26/236 (11.0%). Deaths resulted from organ failures including ARDS, MODS, ARF, DIC and CHF. Clinicians should be aware of the severe organ complications of H1N1, particularly in pregnant and previously healthy young adults
Page 1 and 2:
When citing these abstracts please
Page 3 and 4:
Page 5 and 6:
Page 7 and 8:
Page 9 and 10:
Page 11 and 12:
Page 13 and 14:
Page 15 and 16:
Page 17 and 18:
Page 19 and 20:
Page 21 and 22:
Page 23 and 24:
Page 25 and 26:
Page 27 and 28:
Page 29 and 30:
Page 31 and 32:
Page 33 and 34:
Page 35 and 36:
Page 37 and 38:
Page 39 and 40:
Page 41 and 42:
Page 43 and 44:
Page 45 and 46:
Page 47 and 48:
Page 49 and 50:
Page 51 and 52:
Page 53 and 54:
Page 55 and 56:
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
Page 75 and 76:
Page 77 and 78:
Page 79 and 80:
Page 81 and 82:
Page 83 and 84:
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
Page 91 and 92: When citing these abstracts please
Page 141: When citing these abstracts please
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
Page 225 and 226:
Page 227 and 228:
Page 229 and 230:
Page 231 and 232:
Page 233 and 234:
Page 235 and 236:
Page 237 and 238:
Page 239 and 240:
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
Page 249 and 250:
Page 251 and 252:
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
Page 273 and 274:
Page 275 and 276:
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Page 291 and 292:
Page 293 and 294:
Page 295 and 296:
Page 297 and 298:
Page 299:
show all

14th ICID - Poster Abstracts - International Society for Infectious ...

Create successful ePaper yourself

Delete template?

Save as template?