Medicinal Plants Classification Biosynthesis and ... - Index of
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124<br />

Aracely E. Chávez-Piña <strong>and</strong> Andrés Navarrete<br />

expression <strong>of</strong> those adhesive molecules in gastric tissue <strong>and</strong> study leukocyte adherence on<br />

gastric microcirculation. In addition, TNF-α levels, an inflammatory mediator, was decreased<br />

after Astragaloside IV administration, this event may play a role on its gastric safety [145].<br />

Gastroprotective Triterpenoids<br />

Triterpenoid Plant Physiologic response<br />

3-O-acetyl aleuritolic<br />

acid<br />

Croton cajuara Reduction <strong>of</strong> gastrointestinal transit<br />

in mice<br />

Jatropha isabelli Gastroprotective activity in the<br />

HCl/EtOH induce gastric lesions in<br />

mice<br />

Boswellic acid Boswellia serrata Antiulcer activity<br />

Camellioside A <strong>and</strong> B Camellia japonica Decrement on the lesions induce by<br />

ethanol <strong>and</strong> indomethacin<br />

Araloside A Aralia elata Reduces gastric lesions<br />

Calendasaponins A, B, C<br />

<strong>and</strong> D<br />

Theasaponin A2, E1, E2<br />

<strong>and</strong> E5<br />

Decrement in the lesions induced by<br />

ethanol- <strong>and</strong> indomethacin<br />

administration<br />

Camellia sinensis Decrement in the lesions induced by<br />

ethanol administration<br />

Astragaloside IV Astragalus species Gastroprotective activity in the<br />

experimental model <strong>of</strong> ethanolinduce<br />

gastric lesions in the rat<br />

3αhydroxymasticadienonic<br />

acid<br />

3-epi-oleanolic acid<br />

Amphipterygium<br />

adstringens<br />

Decrement in the lesions induced by<br />

ethanol administration<br />

Carbenoxolone Glycyrrhiza glaba Decrement in the lesions induced by<br />

ethanol administration<br />

Aescine Aesculus hippocastanum Antisecretory mechanism, improves<br />

gastric blood flow<br />

Another triterpenes that would decrease leukocyte adherence are boswellic acid, isolated<br />

from Boswellia serrata. This asseveration is done due to leukocyte adherence is induce by<br />

LTB4 synthesis; while boswellic acid inhibit LTB4 synthesis, being this one <strong>of</strong> the<br />

mechanism <strong>of</strong> its gastric safety [146, 147].<br />

More evidence about gastroprotective mechanism on triterpenoid activity was elucidated<br />

when NEM (N-ethylmaleimide) abolished the gastroprotective effect <strong>of</strong> 3αhydroxymasticadienonic<br />

acid in the experimental model <strong>of</strong> ethanol-induced gastric injury.<br />

This exhibits the role <strong>of</strong> endogenous sulfhydryls in the mechanism <strong>of</strong> triterpenoids [141].<br />

Besides, Momordin Ic, an oleanolic acid oligoglycoside inhibits gastric emptying in<br />

ethanol-induced gastric lesions in mice [148]. Furthermore, this compound inhibited

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