Medicinal Plants Classification Biosynthesis and ... - Index of

Gastroprotective Triterpenoids: Pharmacological Mechanism
In relationship with the chemical structure requirement for triterpenoids to exhibit
gastroprotective properties, it has been found that a hydroxyl group in the C-3 position is
related with its gastroprotective activity.
In conclusion, triterpenoid exhibit gastroprotective properties by PGs, NO and/ or -SH
stimulation. There is another mechanism that remains unexplored such as H2S generation
mainly. Pharmacokinetic studies need to be done about active triterpenoids. It should help to
explain its properties in the organism. Derivatives from natural triterpenes should be a
strategy to improve the gastroprotective effect of this kind of natural products.
7. Acknowledgements
The authors acknowledge to Dirección General de Asuntos del Personal Académico
(DGAPA IN 205008) and Consejo Nacional de Ciencia y Tecnología (CONACYT 82613)
for partial support to study the pharmacology of Mexican natural products. A. Chavez
acknowledges postdoctoral fellowship from DGAPA.
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