Plutonium Biokinetics in Human Body A. Luciani - Kit-Bibliothek - FZK

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By means of Figure 3.1.32 it is possible to calculate the uncertainties associated to Model-b predictions for the daily urinary excretion rate. The plot relating to an exposure via ingestion was calculated with a gut uptake factor f 1 = 5•10 -4 , but it well approximates the plots for all the f 1 factor values. A 5 μm AMAD aerosol was considered for the inhalation case. The curves in Figure 3.1.32 enable to estimate whether a certain experimental measurement is statistically in good agreement with the model predictions and their uncertainty. 136
3.2 APPLICATION OF THE OPTIMIZED MODEL TO A CASE OF CONTAMINATION 3.2.1 HARMONIZATION OF THE ACTIVITY MEASUREMENTS IN BIOASSAYS The contamination case was presented in the paragraph 2.2 of Chapter 2. The results of the Plutonium and Americium measurements on organs and bioassays performed in the frame of the present work are provided in paragraphs 2.3.3 and 2.4.3, respectively. The data from previous measurements campaign carried out on the subject are available from previous studies presented in paragraph 2.2.2. The results of the measurements for the radionuclides content in the urine and feces samples often relate to the total activity of different combinations of Americium and Plutonium radioisotopes. Up to 3902 days post intake the available measurements relate to the total activity of 239 Pu + 240 Pu and to 238 Pu + 241 Am; at 2528 and 2923 days to 238 Pu + 239 Pu + 240 Pu and to the only 241 Am activity (Table 2.2.3). Finally the measurements performed in occasion of the present work (about 6000 days post intake) relates to the total activity of 239 Pu + 240 Pu and to the activity of the only 238 Pu and 241 Am (Table 2.4.1). In order to have the same kind of measurements over all the observation time (from the intake up to the present), the measurements from previous studies relating to the total activity of different radionuclides were recast to reproduce the same kind of results provided in the frame of the present work. For such purpose the ratios of the initial activity of the Plutonium radionuclides present in the inhaled material (see paragraph 2.2.1) were corrected on the basis of the physical decay time of each radionuclide and assuming that all the Plutonium radioisotopes have the same biokinetics (as currently assumed by ICRP). This was carried out particularly for the measurements relating to the total activity of the 238 Pu + 239 Pu + 240 Pu in order to provide them in the form of 238 Pu and 239 Pu + 240 Pu. Such approach is not applicable in order to discriminate the single radionuclide contribution (Plutonium or Americium) to the total activity of 238 Pu + 241 Am because the initial ratio changes with the time not only in relation to the different physical decay times, but also to the different metabolism of the radionuclides in human body. Therefore for the measurements available up to 3902 days post intake the urine and feces content of the single 238 Pu and 241 Am can be evaluated only after the adoption of the appropriate biokinetic model for both Plutonium and Americium. 3.2.2 CLASSIFICATION OF THE AVAILABLE MEASUREMENTS On the basis of the available data in scientific literature and the measurements performed in the frame of the present work, a significant number of data is now available for the considered case of contamination. Data relating to 241 Am activity in lung, liver and bone, and of all the contaminating radioisotopes in urine, feces and blood are available for a time range covering almost 16 years after the contamination event. Apart the accuracy and precision characterizing each type of measurements in relation to the adopted technique, not all the measurements can be considered of the same reliability 137
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Forschungszentrum Karlsruhe in der
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Für diesen Bericht behalten wir un
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i ABSTRACT The biokinetic model pre
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ZUSAMMENFASSUNG Das von der Interna
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1 INDEX OF CONTENTS INDEX OF SYMBOL
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3 INDEX OF SYMBOLS Here a short glo
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Chapter 1 Introduction 5
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the duties of the Department for Ra
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adionuclide. Therefore only isotope
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stabilise the +4 oxidation state [1
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techniques adopted in the early pha
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present in spent and MOX reactor fu
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INTRAVENOUS INJECTION skin WOUND bl
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functions, defined as retained and
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the contamination event, of such as
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Table 1.3.2 Indicative 239 Pu detec
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The kinetics of Plutonium in the ki
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1.4.2 COMMENTS ON THE ICRP 67 MODEL
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Chapter 2 Data and measurements 31
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Therefore the radiolysis process, m
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Recent technologic developments in
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eu(t) = 0.19e −0.272t + 0.023e
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function for each of the considered
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the minimum detectable activity of
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2.2.2 AVAILABLE MEASUREMENTS Immedi
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Table 2.2.4 Daily fecal excretion o
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elements the spectral distribution
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The phoswich detector is based on t
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HPGe crystals are produced in cylin
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This quantity is normally expressed
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The peak is located in the region B
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To introduce the second quantity, t
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117 cm 3 h -1 for the incoming and
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Figure 2.3.8 The Lawrence Livermore
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three detectors are used. Two detec
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Table 2.3.4 Efficiency factors of p
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• the necessity of performing mea
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Table 2.3.7 Impulses in the measure
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2.4 ACTIVITY MEASUREMENTS IN BIOASS
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If more then one radionuclide is ma
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L A is the air layer in µgcm -2 ;
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The electrodeposition cell used for
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Table 2.4.1 238 Pu, 239 Pu and 241
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3.1.1 MATHEMATICAL TOOLS 3.1.1.1 So
Page 95 and 96: calculating the amount of Plutonium
Page 97 and 98: 3.1.2 ANALYSIS OF THE ICRP 67 MODEL
Page 99 and 100: empirical curves given by Langham,
Page 101 and 102: the worst performance of the group.
Page 103 and 104: leave the total clearance from the
Page 105 and 106: Figure 3.1.4 shows that the use of
Page 107 and 108: 3.1.3 MODIFICATION OF ICRP 67 MODEL
Page 109 and 110: The structure of Polig’s skeleton
Page 111 and 112: Percentage daily urinary excretion
Page 113 and 114: of 0.693d -1 . The values of the F
Page 117 and 118: the basis of all the reference data
Page 119 and 120: Table 3.1.10 Transfer rates of the
Page 121 and 122: 3.1.4 VERIFICATION OF THE OPTIMIZED
Page 123 and 124: Table 3.1.13 Intakes and percentage
Page 125 and 126: soft tissue ST2 soft tissue ST0 sof
Page 127 and 128: For the routine application of Mode
Page 129 and 130: excreted by individuals aged sixty
Page 131 and 132: Table 3.1.20 Exponents and coeffici
Page 133 and 134: tract [57] to consider a contaminat
Page 135 and 136: The sensitivity coefficients for th
Page 137 and 138: Sensitivity coefficients S i Figure
Page 139 and 140: transfer rates on the Plutonium uri
Page 141 and 142: Geometric standard deviations rangi
Page 145: Percentage daily urinary excretion
Page 149 and 150: lymph nodes, as in the LLNL phantom
Page 151 and 152: Americium in the lungs [Bq] 1000 10
Page 153 and 154: Daily urinary excretion [Bqd -1 ] 1
Page 155 and 156: long time is not yet described by t
Page 157 and 158: excretion that is one of the main i
Page 159 and 160: The comparison of model’s predict
Page 161 and 162: Americium in the lungs [Bq] 1000 10
Page 163 and 164: 153 CONCLUSIONS The optimized model
Page 165 and 166: Annex Quantities used in Radiologic
Page 167 and 168: present. As the radiation weighting
Page 169 and 170: w R is the radiation weighting fact
Page 171 and 172: 161 BIBLIOGRAPHY 1. Plutonium. W. K
Page 173 and 174: 29. Nenot, J.-C. and Stather, J. W.
Page 175 and 176: 55. International Atomic Energy Age
Page 177 and 178: 81. Crowley, J., Lanz, H., Scott, K
Page 179 and 180: 107. Hempelmann, L.H., Langham,W.H.
Page 181 and 182: 137. Breitestein, B.D., Newton, C.E
Page 183 and 184: 167. Harrison, J.D., Khursheed, A.,
Page 185 and 186: JOURNALS OWN PUBLICATIONS RELATED T
Page 187 and 188: 177 ACKNOWLEDGEMENTS Special thanks
Page 189 and 190: Name: Andrea Luciani Date and place
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Plutonium Biokinetics in Human Body A. Luciani - Kit-Bibliothek - FZK

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