Plutonium Biokinetics in Human Body A. Luciani - Kit-Bibliothek - FZK

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93. Moss W.D. and Guatier, M.A. Additional short-term plutonium urinary excretion data from the 1945-1947 plutonium injection studies. In Occupational Health and Environment Research 1983: Health, Safety and Environment Division, Compiler G.L. Voelz, Los Alamos National Laboratory, Report LA-10365-PR, 29-34, 1985. 94. Tancock, N. P. and Taylor, N. A. Plutonium excretion data from 1945-1947 human injection study: correction fro recovery losses and derivation of rate constant for long-term elimination. Rad. Prot. Dosim. 46(4):241-246, 1993. 95. Lloyd, R.D., Atherton, D. R., McFarland, S. S., Mays, C. W., Stevens, W., Williams, J: L. and Taylor, G. N. Studies of injected 237Pu(IV) citrate in beagles. Health Phys. 30(January):47-52, 1976. 96. Talbot, R. J., Knight, D. A. and Morgan, A. Biokinetics of 237Pu citrate and nitrate in rat: implications for Pu studies in man. Health Phys. 59(2):183-187, 1990. 97. International Commission on Radiological Protection. Dose Coefficients for intakes of radionuclides by workers – Replacement of ICRP Publication 61. Oxford: Pergamon Press; ICRP Publication 68, Ann. ICRP 24(4); 1995. 98. Talbot, R. J., Newton, D. and Warner, A. J. Metabolism of injected plutonium in two healthy men. Health Phys. 65(1):41-46, 1993. 99. Talbot, R. J. and Newton, D. Blood retention and renal clearance of 237Pu in man. In the Proceedings of The International Seminar on health effects of internally deposited radionuclides, Heidelberg, Germany, 18-21 April, 1994. 100. Talbot, R. J., Newton, D. and Dmitriev S. N. Sex-related differences in the human metabolism of plutonium. Rad. Prot. Dosim. 71(2):107-121, 1997. 101. Taylor, D. M. Gender-specific differences in the biokinetics of plutonium and other actinides. Rad. Prot. Dosim. 79(1-4):359-362, 1998. 102. Newton, D., Talbot, R. J., Kang, C. and Warner, A. J. Uptake of plutonium by the human liver. Rad. Prot. Dosim. 80(4):385-395, 1998. 103. Warner, A. J., Talbot, R. J. And Newton, D. Deposition of plutonium in human testes. Rad. Prot. Dosim. 55(1):61-63, 1994. 104. Beach, S. A. and Dolphin, G. W. Determination of plutonium body burdens from measurements of daily urine excretion. In Assessment of radioactivity in man, Vienna, Internatinal Atomic Energy Agency, Vol. II: 603-615, 1964. 105. Robertson, J. S. and Cohn, S. H. Evaluation of plutonium exposures in man. Health Phys. 10(June):373-390,1964. 106. Durbin, P.W. Plutonium in man: a new look at the old data. In Radiobiology of Plutonium, edited by B.J. Stover and W.S.S. Jee, J W Press; 469-530, Salt Lake City, 1972. 168
107. Hempelmann, L.H., Langham,W.H., Richmond, C.R. and Voelz, G.L. Mahattan project Plutonium workers: a twenty-seven year follow-up of selected cases. Health Phys. 25(November):461-479; 1973. 108. Voelz, G.L., Hempelmann, L.H., Lawrence, J.N.P. and Moss, W.D. A thirtytwo year medical follow-up of Manhattan project Plutonium workers. Health Phys. 37(October):445-485, 1979. 109. Parkinson, W. Jr. and Henley, L. C. A proposed long-term excretion equation for Plutonium. Health Phys. 40(March):327-331, 1981. 110. International Commission on Radiological Protection. The metabolism of compounds of Plutonium and other actinides. Oxford: Pergamon Press; ICRP Publication 19; 1972. 111. Jones, S.R. Derivation and validation of a urinary excretion function for Plutonium applicable over tens of years post uptake. Radiat. Prot. Dos. 11(1):19-27; 1985. 112. Leggett, R. W. and Eckerman, K. F. A method for estimating the systemic burden of Pu from urinalyses. Health Phys. 52(3):337-346, 1987. 113. Tancock, N. P. and Taylor, N. A. Derivation of a new expression to describe the urinary excretion of plutonium by man. Rad. Prot. Dosim. 46(4):229-239, 1993. 114. Khokhryakhov, V.F., Menshikh, Z.S., Suslova, K.G., Kudryavtseva, Z.B., Tokarskaya, Z.B. and Romanov, S.A. Plutonium excretion model for the healthy man. Radiat. Prot. Dos. 53(1-4): 235-239; 1994. 115. Leggett, R.W. A model of the retention, translocation and excretion of systemic Pu. Health Phys. 49(6):1115-11137; 1985. 116. Sun, C. and Lee, D. Plutonium fecal and urinary excretion functions: derivation from a systemic hole-body retention function. Heatlh Phys. 76(6):619-627, 1999. 117. Voelz, G.L., Grier, R.S. and Hempelmann, L.H. A 37-year medical follow-up of Manhattan project Pu workers. Health Phys. Vol. 48(3): 249-259, 1985. 118. Voelz, G.L. and L.H., Lawrence. A 42-year medical follow-up of Manhattan project plutonium workers. Health Phys. Vol. 61(2): 181-190, 1991. 119. Voelz, G.L., Lawrence, L.H., and Johnson, E. R. Fifty years of plutonium exposure to Manhattan Project plutonium workers: an update. Health Phys. Vol. 73(4): 611- 619, 1997. 120. Voelz, G.L. Private communication. Los Alamos National Laboratory, Los Alamos, NM, USA, 1998. 121. United States Transuranium and Uranium Registries. Annual Report of the United States Transuranium and Uranium Registries. April 1992 - September 1993, 1993. 169
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Forschungszentrum Karlsruhe in der
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Für diesen Bericht behalten wir un
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i ABSTRACT The biokinetic model pre
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ZUSAMMENFASSUNG Das von der Interna
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1 INDEX OF CONTENTS INDEX OF SYMBOL
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3 INDEX OF SYMBOLS Here a short glo
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Chapter 1 Introduction 5
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the duties of the Department for Ra
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adionuclide. Therefore only isotope
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stabilise the +4 oxidation state [1
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techniques adopted in the early pha
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present in spent and MOX reactor fu
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INTRAVENOUS INJECTION skin WOUND bl
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functions, defined as retained and
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the contamination event, of such as
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Table 1.3.2 Indicative 239 Pu detec
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The kinetics of Plutonium in the ki
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1.4.2 COMMENTS ON THE ICRP 67 MODEL
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Chapter 2 Data and measurements 31
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Therefore the radiolysis process, m
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Recent technologic developments in
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eu(t) = 0.19e −0.272t + 0.023e
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function for each of the considered
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the minimum detectable activity of
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2.2.2 AVAILABLE MEASUREMENTS Immedi
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Table 2.2.4 Daily fecal excretion o
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elements the spectral distribution
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The phoswich detector is based on t
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HPGe crystals are produced in cylin
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This quantity is normally expressed
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The peak is located in the region B
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To introduce the second quantity, t
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117 cm 3 h -1 for the incoming and
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Figure 2.3.8 The Lawrence Livermore
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three detectors are used. Two detec
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Table 2.3.4 Efficiency factors of p
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• the necessity of performing mea
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Table 2.3.7 Impulses in the measure
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2.4 ACTIVITY MEASUREMENTS IN BIOASS
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If more then one radionuclide is ma
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L A is the air layer in µgcm -2 ;
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The electrodeposition cell used for
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Table 2.4.1 238 Pu, 239 Pu and 241
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3.1.1 MATHEMATICAL TOOLS 3.1.1.1 So
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calculating the amount of Plutonium
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3.1.2 ANALYSIS OF THE ICRP 67 MODEL
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empirical curves given by Langham,
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the worst performance of the group.
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leave the total clearance from the
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Figure 3.1.4 shows that the use of
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3.1.3 MODIFICATION OF ICRP 67 MODEL
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The structure of Polig’s skeleton
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Percentage daily urinary excretion
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of 0.693d -1 . The values of the F
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Percentage daily urinary excretion
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the basis of all the reference data
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Table 3.1.10 Transfer rates of the
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3.1.4 VERIFICATION OF THE OPTIMIZED
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Table 3.1.13 Intakes and percentage
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soft tissue ST2 soft tissue ST0 sof
Page 127 and 128: For the routine application of Mode
Page 129 and 130: excreted by individuals aged sixty
Page 131 and 132: Table 3.1.20 Exponents and coeffici
Page 133 and 134: tract [57] to consider a contaminat
Page 135 and 136: The sensitivity coefficients for th
Page 137 and 138: Sensitivity coefficients S i Figure
Page 139 and 140: transfer rates on the Plutonium uri
Page 141 and 142: Geometric standard deviations rangi
Page 143 and 144: Percentage daily urinary excretion
Page 145 and 146: Percentage daily urinary excretion
Page 147 and 148: 3.2 APPLICATION OF THE OPTIMIZED MO
Page 149 and 150: lymph nodes, as in the LLNL phantom
Page 151 and 152: Americium in the lungs [Bq] 1000 10
Page 153 and 154: Daily urinary excretion [Bqd -1 ] 1
Page 155 and 156: long time is not yet described by t
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Page 159 and 160: The comparison of model’s predict
Page 161 and 162: Americium in the lungs [Bq] 1000 10
Page 163 and 164: 153 CONCLUSIONS The optimized model
Page 165 and 166: Annex Quantities used in Radiologic
Page 167 and 168: present. As the radiation weighting
Page 169 and 170: w R is the radiation weighting fact
Page 171 and 172: 161 BIBLIOGRAPHY 1. Plutonium. W. K
Page 173 and 174: 29. Nenot, J.-C. and Stather, J. W.
Page 175 and 176: 55. International Atomic Energy Age
Page 177: 81. Crowley, J., Lanz, H., Scott, K
Page 181 and 182: 137. Breitestein, B.D., Newton, C.E
Page 183 and 184: 167. Harrison, J.D., Khursheed, A.,
Page 185 and 186: JOURNALS OWN PUBLICATIONS RELATED T
Page 187 and 188: 177 ACKNOWLEDGEMENTS Special thanks
Page 189 and 190: Name: Andrea Luciani Date and place
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Plutonium Biokinetics in Human Body A. Luciani - Kit-Bibliothek - FZK

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