The Clinical Guide to Supportive and Palliative Care for HIV/AIDS

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A Clinical Guide to Supportive and Palliative Care for HIV/AIDS • Chapter 27: Pharmacologic Interactions of Clinical SignificanceTable 27-12:Summary of Significant Drug-Drug Interactionsin Palliative Care of HIV Disease (continued)DISEASE Disease STATES Statesand MedicationsNucleoside NUCLEOSIDE REVERSE ReverseTranscriptase TRANSCRIPTASE INHIBITORSInhibitorsZidovudine Didanosine Abacavir(Retrovir) (Videx) (Ziagen)ILLEGAL DRUGSEcstasyAlcoholCocaineAvoid in patients with family or personal history of depressionor anxiety disorders because the drug damages the serotoninneurons.↑ risk ofpancreatitisAvoid in patients with family or personal history of depressionor anxiety disorders because the drug damages the serotoninneurons.LSDNo knowninteractionsNo knowninteractionsNo knowninteractionsAlternative AgentsInteractionsAlternativesCardiovascular Simvastatin, lovastatin, Pravastatin, fluvastatincerivastatin, atorvastatinGastrointestinal Cimetidine Famotidine, ranitidineRespiratory Astemizole, terfenadine, Loratidine, fexofenadinecetirizine, nasal steriodsCNS Alprazolam, diazepam, Temazepam, lorazepamflurazepam, midazolam,triazolamAnalgesics Meperidine, propoxyphene, Hydromorphone, codeinefentanyl, tramadolAntimycobacterial Clarithromycin Azithromycin, ethambutolOral Contraceptive Ethinyl estradiol Ethinyl estradiol + condom582U.S. Department of Health and Human Services • Health Resources and Services Administration • HIV/AIDS Bureau
A Clinical Guide to Supportive and Palliative Care for HIV/AIDS • Chapter 27: Pharmacologic Interactions of Clinical SignificanceTable 27-13:26 picasAzole antifungalsMacrolidesHIV medicationsOthersCommon Red Flag Medications Often Usedin Palliative Care of HIV DiseaseCYP450 Enzyme InhibitorsFluconazole (Diflucan), ketoconazole (Nizoral), itraconazole(Sporonox)Erythromycin, clarithromycin (Biaxin)Ritonavir (Norvir), ritonavir + lopinavir (Kaletra), indinavir(Crixivan), nelfinavir (Viracept), saquinavir (Fortovase,Invirase), amprenavir (Agenerase), delavirdine (Rescriptor),efavirenz (Sustiva)Cimetidine (Tagamet), amiodarone (Cordarone)CYP450 Enzyme InducersAnticonvulsantsRifamycinsHIV medicationsAntiarrhythmicsErgot alkaloidsOthersPhenobarbital, phenytoin (Dilantin), carbamazepine (Tegretol)Rifabutin (Mycobutin), rifampin (Rifadin, Rimactane)Nelfinavir (Viracept), nevirapine (Viramune), ritonavir(Norvir), efavirenz (Sustiva)Drugs with Narrow Therapeutic IndexFleicanide (Tambocor), encainide (Enkaid), quinidineErgotamine tartrate (Cafergot, others)Digoxin (Lanoxin), oral contraceptives, thophylline, warfarin(Coumadin)Drugs with Specific Absorption RequirementsAzole antifungalsFluoroquinolonesHIV medicationsOther medicationsItraconazole (Sporonox), ketoconazole (Nizoral)Levofloxacin (Levaquin), ciprofloxacin (Cipro), enoxacin(Penetrex), moxifloxacin (Avelox), norfloxacin (Noroxin),ofloxacin (Floxin), trovafloxacin (Trovan)Didanosine (Videx), ritonavir (Norvir), nelfinavir (Viracept),saquinavir (Fortovase, Invirase)MAO inhibitors, cyclosporine (Neoral, Sandimmune),alendronate (Fosamax)XXVIIU.S. Department of Health and Human Services • Health Resources and Services Administration • HIV/AIDS Bureau 583
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DedicationA Clinical Guide to Suppo
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Lynn A Jansen, RN, PhDAssistant Res
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TABLE OF CONTENTSPart IChapter 1Cha
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IChapter 1.26 picasHIV and Palliati
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IA Clinical Guide to Supportive and
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A Clinical Guide to Supportive and
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Chapter 6.26 picasPulmonary Symptom
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Chapter 8.26 picasOral ProblemsDavi
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Chapter 9.26 picasDermatologic Prob
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Chapter 10.26 picasPsychiatric Prob
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Chapter 11.26 picas Substance Use P
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Chapter 14.26 picasCulture and Care
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Chapter 15.26 picasSpecial Populati
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Chapter 17.26 picasEthical IssuesLy
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Chapter 18.26 picasLegal and Financ
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Chapter 19.Palliative 26 picas Care
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Chapter 25.26 picas Prevention of S
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Chapter 26.26 picasResourcesMagda B
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