Development of Karl Fischer Reagents

Substance pKa
Sample quantity
(g)
Chapter II: Applications - 1
Measurement
value (µg)
Moisture
content (%)
i-Propylamine 10.6 0.694 321 463ppm
n-Butylamine 10.6 0.732 2440 0.333
n-Hexylamine 10.6 0.766 496 648ppm
Diethylamine 11.0 0.707 989 0.140
Di-i-propylamine 11.1 0.722 931 0.129
Di-n-butylamine 11.3 0.760 3231 0.425
Triethylamine 10.7 0.726 5582 0.769
Tri-n-propylamine 10.7 0.753 1159 0.154
Tri-n-butylamine 10.9 0.778 626 805ppm
3-Dimethylamino propionitrile 6.9 0.870 2635 0.303
Cyclohexylamine 10.6 0.867 1741 0.201
Monoethanolamine 9.5 0.269 614 0.228
Diethanolamine 9.0 1.097 1199 0.109
Triethanolamine 7.8 1.124 1870 0.166
2-Diethylaminoethanol 9.4 0.884 2757 0.312
1,3-Diaminopropane 0.218 1471 0.675
1,2-Propane diamine Cannot be measured
Pyrrolidine 11.3 Cannot be measured
Piperidine 11.2 0.861 3971 0.461
4-Benzyl piperidine 10.3 0.997 6314 0.633
Piperazine 0.200 210 0.105
Pyrrole 0.967 3104 0.321
N-Methyl morpholine 7.7 0.905 1907 0.211
Benzylamine 9.4 0.268 452 0.169
N,N-Dimethyl benzylamine 8.9 0.900 1042 0.116
2-Amino-3-picoline 6.7 1.031 2621 0.254
2-Methyl aminopyridine 6.7 1.052 1280 0.122
o-Toluidine 4.4 Cannot be measured
m-Toluidine 4.7 Cannot be measured
p-Anisidine 5.3 Cannot be measured
m-Aminophenol 4.2 Cannot be measured
Dimethyl aminomethyl phenol 7.9 0.986 1606 0.163
N,N-Dimethyl-p-toluidine 5.6 0.937 494 527ppm
Aniline 4.6 Cannot be measured
N,N-Diethyl aniline 6.6 0.938 102 109ppm
o-Chloro-aniline 2.6 1.213 361 298ppm
2-Anilinoethanol 4.0 1.085 2614 0.241
99