Development of Karl Fischer Reagents
Development of Karl Fischer Reagents
Development of Karl Fischer Reagents
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III-1. Industrial Products<br />
4) Dehydrated Solvent MS+pyridine : metanilic acid,<br />
o-toluenesulfonamide, C-acids<br />
5) Dehydrated Solvent MS+dichloromethane : nitro compounds,<br />
some chloro compounds<br />
Coulometric titration can be used. However, interference reactions<br />
make it unsuitable for some substances (* e.g. anilines and other<br />
electrode-reactive substances).<br />
Substances for which coulometric titration cannot be used<br />
Anilines, p-anisidines, m-aminophenols, p-chloroanilines, p-toluidines,<br />
metanilic acid<br />
[Examples <strong>of</strong> Measurement]<br />
(1) Volumetric titration<br />
<strong>Reagents</strong> used: <strong>Karl</strong> <strong>Fischer</strong> Reagent SS-Z (or SS)<br />
Dehydrated Solvent GEX, KT (or MS, CP) 25-50ml<br />
154<br />
Substance Dehydrated solvents<br />
Sample Quantity<br />
(g)<br />
Measurement Value<br />
(mg)<br />
Moisture Content<br />
(ppm)<br />
p-Toluidines CP+acetic acid (2:1) 2.9253 0.89 304<br />
p-Anisidines " 2.0115 0.46 229<br />
p-Phenetidines " 1.1072 1.68 0.152%<br />
m-Aminophenols " 1.0152 0.29 286<br />
Anthranilic acid General-use 1.0164 0.11 108<br />
Diphenyl amine " 8.3429 0.25 30<br />
2-Aminonaphthalene " 0.5290 1.62 0.306%<br />
-1-sulfonic acid<br />
Sodium naphthionate " 0.0593 13.45 22.7<br />
J-acid " 0.1051 5.88 5.60%<br />
Carbonyl J-acid " 0.2062 6.15 2.98%<br />
m-Nitroaniline " 1.5089 0.95 630<br />
p-Nitrophenol " 0.9844 11.30 1.15%<br />
1-Hydroxy-2-naphthoicacid " 2.0959 0.54 258<br />
Anilines Ketone-type 2.1601 1.92 889<br />
5-Amino-2-chlorotoluene MS+pyridine (5:1) 1.9911 0.09 45<br />
-4-sulfonate(C-acid)
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