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Development of Karl Fischer Reagents

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1. <strong>Karl</strong> <strong>Fischer</strong> Reagent SS-Z, SS<br />

Chapter I: Basic Knowledge<br />

Initially the titer <strong>of</strong> <strong>Karl</strong> <strong>Fischer</strong> reagents was unstable, and it was necessary<br />

to use them in the extremely inconvenient form <strong>of</strong> binary solutions.<br />

Mitsubishi Chemical was the first manufacturer in the world to perfect a<br />

single solution version, which it called "<strong>Karl</strong> <strong>Fischer</strong> Reagent SS". In the 50<br />

years since that time, Mitsubishi Chemical has continued to enhance and<br />

expand its technology, and today enjoys an excellent reputation for its<br />

superior products.<br />

Mitsubishi Chemical has also developed <strong>Karl</strong> <strong>Fischer</strong> Reagent SS-Z, which<br />

is pyridine-free and does not contain chlor<strong>of</strong>orm or methyl cellosolve. Users<br />

can choose from an extensive product range, as listed below.<br />

Product Purpose Titer Applications Packaging<br />

SS 10mg<br />

SS-Z 5mg<br />

SS-Z 3mg<br />

SS 3mg<br />

SS-Z 1mg<br />

SS 1mg<br />

Samples with high moisture<br />

content (40% or higher)<br />

General normal<br />

samples<br />

General normal<br />

samples<br />

Samples with low moisture<br />

content (0.1% or lower)<br />

8-12mg/ml<br />

4.5-5.5mg/ml<br />

2.5-3.5mg/ml<br />

0.7-1.2mg/ml<br />

Foodstuffs, Cosmetics<br />

Detergents, etc<br />

General samples, Organic<br />

solvents<br />

General samples, Organic<br />

solvents<br />

Organic solvents, Petroleum<br />

products, Gas products<br />

500ml bottles<br />

500ml, 1L<br />

bottles<br />

500ml bottles<br />

500ml bottles<br />

<strong>Karl</strong> <strong>Fischer</strong> Reagent SS-Z:<br />

Pyridine-Free and Methyl Cellosolve-Free Types<br />

Instead <strong>of</strong> pyridine, <strong>Karl</strong> <strong>Fischer</strong> SS-Z contains a solid amine. As a result,<br />

the product is free <strong>of</strong> the pyridine odor. All the ingredients required to<br />

implement <strong>Karl</strong> <strong>Fischer</strong> reactions stoichiometrically are included in a single<br />

solution. The product is available in either 5mg/ml, 3mg/ml or 1mg/ml titer.<br />

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