8th Liquid Matter Conference September 6-10, 2011 Wien, Austria ...

P5.114Wed 711:10-14:00Small-angle X-ray scattering studies of nanoparticles insolution for biological and drug delivery applicationsChristian Moitzi 1 and Heinrich Santner 11 Anton Paar GmbH, Anton Paar Str. 20, 8054, Graz, AustriaSmall-angle X-ray Scattering (SAXS) is a wide-spread method for the characterization of nanostructuredmaterials. The results obtained by SAXS are an important supplement to results fromcomplementary methods for nanostructure analysis, like electron microscopy or crystallography.The advantage of SAXS for bio- and bio-relevant materials such as proteins or drug delivery systemsis that it allows investigating these nanoparticles in solution, i. e. under biological conditions.The following important parameters can be determined by SAXS: · Shape of nanoparticles · Sizeof nanoparticles ·. Internal structure (core/shell particles) Laboratory SAXS experiments requirea sophisticated design of the SAXS system in order to achieve excellent data quality (comparableto synchrotron SAXS beamlines) at reasonable measurement times. Especially for low-contrastsamples (contrast in SAXS is the difference in electron density between the nanoparticle and thematrix) like proteins or drug delivery materials, the design and collimation concept 1 as well as thequality of the SAXS system is of great importance. In this contribution we will show some examplesof structural characterization of bio-relevant nanomaterials with the SAXSess mc 2 laboratorysystem. SAXSess mc 2 is ideally suited for the analysis of e. g. low-concentrated protein solutionsor drug delivery systems within minutes. Therefore, it can be used for time-resolved monitoringof structural changes. Furthermore, many samples can be screened by use of a fully integratedautosampler.[1] O. Glatter and O. Kratky, Small Angle X-ray Scattering, Academic, London, 2006114