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8th Liquid Matter Conference September 6-10, 2011 Wien, Austria ...

8th Liquid Matter Conference September 6-10, 2011 Wien, Austria ...

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P5.172Wed 711:<strong>10</strong>-14:00Biopolymer based colloidal particles as functionaldelivery systemsKrassimir Velikov 1 and Ashok Patel 11 Unilever RD Vlaardingen, Olivier van Noortlaan 120, 3133 AT, Vlaardingen,NetherlandsThere is a great interest in natural polymeric materials for development of colloidal delivery systemsfor bioactive molecules. The current talk will focus on the synthesis and characterisation ofcolloidal particles from zein, a water insoluble protein from maize. We will discuss the preparation,characterisation and application of zein-curcumin composite colloidal particles. Particle sizeand morphology are studied with dynamic light scattering and transmission electron microscopy.Differential scanning calorimetry and X-ray diffraction are used to quantify the crystalline stateof the entrapped curcumin. UV irradiation is used to study the photostability of curcumin. Theparticle stability is studied at different physiologically relevant pH values and in simulated gastrointestinalconditions. Finally, the mucoadhesion properties of the particles are evaluated using invitro washed off method on agarose gels and mucin association on Caco-2 cells.172

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