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Guidelines for Complications of Cancer Treatment Vol VIII Part B

Guidelines for Complications of Cancer Treatment Vol VIII Part B

Guidelines for Complications of Cancer Treatment Vol VIII Part B

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1) Recipient site problems- The majority <strong>of</strong> recipient site complications are relatedto vascular thrombosis. The incidence <strong>of</strong> vascularthrombosis requiring urgent re exploration is about sixpercent.- Venous thrombosis far outnumbers the arterialthrombosis.- Majority <strong>of</strong> vascular thrombosis occurs within 3 days <strong>of</strong>surgery.- Late thrombosis mainly results from local infection,subsequent fistula <strong>for</strong>mation or mechanical compression.- There is no difference in the rates <strong>of</strong> exploration or flapfailure as a function sex or age.- Potential <strong>for</strong> thrombosis exists in all microvascularanastomosis.- The use <strong>of</strong> drugs to prevent thrombosis is heavily debatedand not universally agreed.- There is no level I evidence <strong>of</strong> utility <strong>of</strong> these drugs orsuperiority <strong>of</strong> one drug over another as prophylaxis inprevention <strong>of</strong> thrombosis.- At our centre, we do not use any thromboprophylactiveagents because <strong>of</strong> their potential side effects andunproven benefit.2) Monitoring Flap Viability- Clinical monitoring <strong>of</strong> flap by response to prick byhypodermic needle is most common and reliable.- Normal color, temperature, absence <strong>of</strong> congestion oredema and slow bright red blood on needle prick is thesign <strong>of</strong> adequate perfusion <strong>of</strong> flap.- A flap with venous congestion is edematous, bluish, coldand on needle prick shows brisk and pr<strong>of</strong>use flow <strong>of</strong>dark blood.185

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