Guidelines for Complications of Cancer Treatment Vol VIII Part B

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Section — IIIRadiotherapyContributorsDr Shyam K Shrivastava, MD, DNB, ProfessorDr Rajeev Sarin, MD, FRCR, ProfessorDr Mary Ann Muckaden, MD, ProfessorDr Jai Prakash Agarwal, MD, Additional ProfessorDr Rakesh Jalali, MD, Associate ProfessorDr Siddhartha Laskar, MD, DNB, Associate ProfessorDr Tejpal Gupta, MD, DNB, Assistant ProfessorDr Umesh Mahantshetty, MD, DNB, Assistant ProfessorDr Reena Engineer, DMRT, DNB, Assistant ProfessorDr Anusheel Munshi, MD, DNB, Assistant ProfessorDr Vineeta Goel, MD, DNB, Assistant ProfessorDr Puneet Pareek, MD, Senior RegistrarDr Debnarayan Dutta, MD, Senior Registrar
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Guidelines forComplications ofCance
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Dedicated toAll our patients atThe
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Section IIHead & Neck 151Complicati
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PrefaceTreatment of cancer by vario
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Section — IGeneralContributorsDr.
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6. Complications after breast recon
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promises to reduce this risk of ser
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preceded by increased sensory hyper
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had significant lymphoedema. The fa
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2. Smoking as a risk factor for wou
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4. Preoperative core needle biopsy
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eduction mammoplasty, and axillary-
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postoperative wound infection follo
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ablative surgical treatment for car
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postoperative seroma formation usin
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dressing consisted of a circumferen
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mastectomies with axillary node cle
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mastectomy for breast cancer. Early
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monitored for the development of po
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modality, and tumor stage distribut
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26. Pain and other symptoms during
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28. Coping, catastrophizing and chr
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surgical technique at the time of m
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0.001), 0.315 cm +/- 1.27 at the an
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or heat and superficial incision is
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RecommendationsA. Preparation of th
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3. Mangram AJ, Horan TC, Pearson ML
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Mild hypothermia increases blood lo
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Perioperative Normothermia to Reduc
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Priorities: Restoration of circulat
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than 1.5 times control values but f
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outcomes that may result from the u
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Preoperative Preparation of the Pat
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patients, or other patients who may
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Obstruction can occur at the level
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c. Administer face mask preoxygenat
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5. The use of exhaled carbon dioxid
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disorder) may occur after an episod
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undergoing general anesthesia, eith
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anesthesia awareness occurred in ea
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The current guidelines are actually
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o S - Strong Recommendation -Commit
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oSource control ASAP after successf
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oooWean steroids once vasopressors
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Mechanical ventilation of sepsis-in
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o CVVH offers easier management inh
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critically ill patient that are con
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Rivers E, Nguyen B, Havstad S, et a
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in survival of 7.6%. By the second
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parameters (gastric mucosal Pco2, s
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syndrome. We therefore conducted a
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Complications After Limb SalvageSur
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local tumor and to preserve as much
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femoral head to the center of the k
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4. Griffin AM, Parsons JA, Davis AM
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20. Roberts P, Chan D, Grimer RJ, e
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An infection can have disastrous co
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and facilitating reimplantation sur
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features of a two-stage revision is
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patients had an amputation. Two oth
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its main role is confined to ruling
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2. Capanna R, Morris HG, Campanacci
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21. Wilson MG, Kelley K, Thornhill
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39. Love C, Marwin SE, Tomas MB, Kr
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5. A systematic review of 25 RCT’
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(cefazolin or cefuroxime) or penici
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should be based on the isolates fro
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such as concomitant use of prophyla
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Surgical techniqueAdherence to meti
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2. Another small prospective random
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Antibiotic prophylaxis for dental a
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Antimicrobial Prophylaxis in Orthop
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35. Tai CC, Nirvani AA, Holmes A, e
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53. Parker MJ, Roberts C. Closed su
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Vessel Related Issues in Sarcoma:Ev
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sequences may be of value. They cau
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an excellent alternative to amputat
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5. Hünerbein M, Hohenberger P, Str
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Oral IncompetenceOral competence is
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flap is insensate and has no motor
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16. R. Song, Y. Gao, Y. Song, Y. Yu
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The incidence is usually lower afte
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Late fibrotic phase: Attempted tiss
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Ref: A Lyons, N Ghazali/ British J
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17. Store G, Boysen M. Mandibular o
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amino acids, proteins and traces of
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RTOG, EORTC and CTCAE, version 3 fo
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difference in the disease related p
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References1. Bourhis J, Rosine D. R
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with head and neck cancer. N Engl J
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MucositisMucositis is an inflammato
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Type of cancer: high risk for mucos
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Oral care protocol1. Brush all toot
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3. El-Sayed S, Nabid A, ShelleyW, e
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1) Recipient site problems- The maj
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estoration of vascular flow to tiss
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General Complications- Deep vein th
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Nerve Injuries(Recurrent and Superi
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paramedian position, it will result
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along with its variations, and a me
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anatomy as related to surgery of th
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Risk factorsCentral compartment (Le
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Goal - To raise serum calcium level
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Pharyngocutaneous Fistula (PC Fistu
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Based on our institutional practice
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fistula: The Memorial University ex
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Risk factors (LOE-5)Patient factors
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Page 226 and 227: Filntisis, G.A., et al. “Laryngea
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Page 230 and 231: ManagementPostural exercisesDisorde
Page 232 and 233: References1) Objective assessment o
Page 234 and 235: Diagnosis Average time to hypothyro
Page 236 and 237: Management of Facial Nerve InjuryIn
Page 238 and 239: 2. Interposition or cable graft (to
Page 240 and 241: Prevention of corneal exposure Tars
Page 242 and 243: flushing) and localized sweating (g
Page 244 and 245: Other options :1. Intracutaneous in
Page 246 and 247: Shoulder Dysfunction or PainfulShou
Page 248 and 249: EMG studies on scapulo-humeral and
Page 250 and 251: Chyle Fistula after Neck Dissection
Page 252 and 253: Rationale:LCTs, which constitute 70
Page 254 and 255: CSF Leak after Craniofacial Resecti
Page 256 and 257: to the muscle to recreate the orbit
Page 258 and 259: Conservative treatmentIt is logical
Page 260 and 261: Complications Associated with use o
Page 262 and 263: Following is the example of hematol
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Page 268 and 269: in most of the patients. The common
Page 272 and 273: Complications of Abdomino-PelvicRad
Page 274 and 275: With these doses, the rate of necro
Page 276 and 277: sigmoid colon and rectum being in c
Page 278 and 279: complication rate of late rectal to
Page 280 and 281: after radiation therapy, bladder ir
Page 282 and 283: partial symptomatic resolution (P =
Page 284 and 285: increased with concurrent administr
Page 286 and 287: Suggested Reading:1. Hall EJ. Radio
Page 288 and 289: Radiation Induced Second MalignantN
Page 290: Table I: Risk of subsequent cancer
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Page 295 and 296: modality treatment than RT alone (6
Page 297 and 298: vulva, anal canal and oropharynx) a
Page 299 and 300: Registries, 1973-2000. National Can
Page 301 and 302: Suggested Reading:1. Goldsby R, Bur
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Page 305 and 306: dose. The excess relative risk for
Page 307 and 308: Radiation Induced Cardiac &Pulmonar
Page 309 and 310: Acute fibrinous pericarditis can pr
Page 311 and 312: Cardiac Morbidity & MortalityCardio
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Page 315 and 316: 3. Mittal S, Berko B, Bavaria J, et
Page 317 and 318: Carver JR, Shapiro CL, Ng A, Jacobs
Page 319 and 320: RESULTS: In the total group, the ri
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For women diagnosed during 1993-200
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5.4%, SE 1.3, 2p=0.0002; overall mo
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PneumonitisThe clinical syndrome of
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Measurable end points of Pulmonary
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Useful radiation therapy planning p
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7. Rubin, P. Radiation toxicity: Qu
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profibrotic cytokines and molecules
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Graham MV, Purdy JA, Emami B, Harms
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Radiation MyelopathyIntroduction:Sp
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probably secondary to damage to the
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Time Course of Events: The onset ma
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since previous treatment, although
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tried 36 . Novel therapies as stem
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14. Abramson N, Cavanaugh PJ. Short
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MRI in differentiating spinal cord
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acceptability of the types of treat
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Radiation Induced Central NervousSy
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sensory or motor impairment. Numero
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Randomized trial in craniospinal ra
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RT to brain has been implicated as
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that there will be higher probabili
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Pseudo-progression needs to be diff
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CONCLUSION: The results document a
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Intelligence Score Chart (WISC), wh
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hypothesized ordering of groups in
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PATIENTS AND METHODS: Follow-up stu
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had undergone surgical procedure in
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which mirrors the increased inciden
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with population incidence rates thr
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Section — IVMedical OncologyContr
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Initial investigations - Complete b
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In low risk group, patient may rece
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trial design issues.1 Fluconazole s
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Duration of treatment may depend up
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Antibacterial agents-Overall risk E
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Gram positive DOSE Spectrum Comment
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Broad spectrum DOSE Spectrum Commen
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6. Bow EJ, Rotstein C, Noskin GA, e
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2. Delayed CINV: Nausea and vomitin
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Recommended Treatment OptionsAcute
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Evidence Based Management Guideline
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Management of refractory and breakt
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serotonin antagonist and dexamethas
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(no vomiting and no use of rescue t
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within 24 hours after the start of
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with age, often becoming clinically
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guidelines for screening & manageme
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Level Treatment Method of Frequency
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15. Wallace WH, Blacklay A, Eiser C
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health status domains were assessed
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of childhood cancer survivors is no
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Tumor Lysis SyndromeDefinition: Tum
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the grade of CTLS is defined by the
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Alkalinization for patients who wil
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deficiency should include a thoroug
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icarbonate and calcium should not b
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and should have ready access to ras
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Table 3 Risk Factors for Tumor Lysi
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Table 5 Recommended Rasburicase Dos
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1. Guidelines for the management of
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3. A randomized comparison between
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acid levels (6.4-16.8 mg/dl; median
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adiographic pattern is the hilar ly
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study involving 105 patients was 8.
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10. Sostman HD, Matthay RA, Putman
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distinguish between a normal GFR an
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of methotrexate induced nephropathy
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Bibliography1. De Jonge MJ, Verweij
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Mucositis and GastrointestinalToxic
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pathogenesis is similar for gastroi
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acceptable oral protocol include re
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Treatment of gastrointestinal mucos
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Hepatotoxicity ofChemotherapeutic A
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Capecitabine is the prodrug for 5-F
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Topotecan causes elevation of trans
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Daunorubicin: Reduce dose by 25% if
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9. Spriggs DR, Stopa E, Mayer RJ, e
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Dermatologic Toxicity of Antineopla
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ecause 15% of scalp hairs are not i
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5. Batchelor D. Hair and cancer che
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Anemia and Cancer - incidence, etio
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most accurate method for detecting
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levels, to define anemia and this m
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Darbopoietin Vs Epoetin Alfa: Is Th
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arm (2.4 g/dl) compared to patients
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12. Yellen SB, Cella DF, Webster K,
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490NOTES
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NOTES
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Guidelines for Complications of Cancer Treatment Vol VIII Part B

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