Guidelines for Complications of Cancer Treatment Vol VIII Part B

aseline. Male sex, longer symptomatic interval, pre-CRTchemotherapy, pre-existing endocrine deficiencies,hydrocephalus, and younger age at CRT (< 5 years) werepredictive of a significant decline in reading scores over time.CONCLUSION: CRT may result in better long-term cognitiveoutcomes when compared to conventional radiation therapyapproaches. Reading appears more vulnerable than otheracademic skills and may decline over time despite stableintellectual functioning.3. Neuropsychological profile in children with lowgradebrain tumours before starting treatment withfocal RT: baseline data from an ongoing randomisedtrial. Jalali R, Dutta D, Goswami S, Develekar R, SarinR, Dinshaw KA. Neurooncol; Oct 2007: 588The objective was to report neuropsychological profile andactivities of daily living in the pediatric patient populationwith residual/progressive low-grade brain tumors beforestarting focal radiotherapy (RT). The aim is to report thebaseline pre-RT data collected in an ongoing prospectiverandomized trial comparing stereotactic conformal RT versusconventional RT in these patients to generate level 1 evidencefor the efficacy of high-precision RT techniques. Between April2001 and April 2007, out of 93 children and young adults (5–25 years) accrued so far, the present analysis focuses on 60pediatric patients (46 males, 14 females) in the age group of5–16 years. Prior surgery was in the form of partial excisionin 29 patients, subtotal excision in 16 patients, and biopsy in15 patients. Tumor subtypes included 18 chiasmatichypothalamicgliomas, 17 craniopharygiomas, 14 cerebellarastrocytomas, 8 supratentorial low-grade gliomas, and 3ependymomas. Patients underwent a detailed baselineneuropsychological evaluation as per designed protocol.Neuropsychological function was assessed by Wechsler357