Guidelines for Complications of Cancer Treatment Vol VIII Part B

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Section IIHead & Neck 151Complications after Treatment for Oral Cavity Cancer1 Oral Incompetence 1532 Osteoradionecrosis of the Mandible 1583 Xerostomia 1664 Mucositis 1775 Problems Associated with Free Tissue Transfers 184Complications after Thyroid Surgery1 Nerve Injuries 191(Recurrent and Superior Laryngeal Nerve)2 Hypocalcemia Following Thyroidectomy 198Complications after Treatment for Laryngeal andHypopharyngeal Cancer1 Pharyngocutaneous Fistula (PC Fistula) 2032 Post-Laryngectomy Tracheostomal Stenosis 2083 Chondroradionecrosis 2124 Swallowing Dysfunction after Treatment for the 218Oro-Hypopharynx and Larynx5 Hypothyroidism After Treatment for 224Head Neck CancersComplications after Parotid Surgery1 Management of Facial Nerve Injury 2272 Frey’s Syndrome 232Complications after Neck Dissection1 Shoulder Dysfunction 2372 Chyle Fistula after Neck Dissection 241Complications after Craniofascial Resection1 CSF Leak after Craniofacial Resections 245
Post chemotherapy Complications1 Complications Associated with use of 251Chemotherapy Agents for Treatment ofHead and Neck CancersSection IIIRadiotherapy 2611 Complications of Abdomino- 263Pelvic Radiotherapy2 Radiation Induced Second Malignant Neoplasm 2793 Radiation Induced Cardiac & Pulmonary 298Complications4 Radiation Myelopathy 3285 Radiation Induced Central Nervous System 344ComplicationsSection IVMedical Oncology 3711 Febrile Neutropenia 3732 Chemotherapy Induced Nausea and Vomiting 3933 Late Effects in Childhood Cancer Survivors 407Guidelines for Evaluation & Monitoring4 Tumor Lysis Syndrome 4205 Pulmonary Toxicity of Antineoplastic Therapy 4416 Nephrotoxicity of Chemotherapeutic Drugs 4477 Mucositis and Gastrointestinal Toxicities of 454Chemotherapy8 Hepatotoxicity of Chemotherapeutic Agents 4629 Dermatologic Toxicity of Antineoplastic 472Therapy10. Cancer Induced Anemia (CIA) 477
Page 1 and 2: Guidelines forComplications ofCance
Page 3: Dedicated toAll our patients atThe
Page 8 and 9: PrefaceTreatment of cancer by vario
Page 10: Section — IGeneralContributorsDr.
Page 13 and 14: 6. Complications after breast recon
Page 15 and 16: promises to reduce this risk of ser
Page 17 and 18: preceded by increased sensory hyper
Page 19 and 20: had significant lymphoedema. The fa
Page 21 and 22: 2. Smoking as a risk factor for wou
Page 23 and 24: 4. Preoperative core needle biopsy
Page 25 and 26: eduction mammoplasty, and axillary-
Page 27 and 28: postoperative wound infection follo
Page 29 and 30: ablative surgical treatment for car
Page 31 and 32: postoperative seroma formation usin
Page 33 and 34: dressing consisted of a circumferen
Page 35 and 36: mastectomies with axillary node cle
Page 37 and 38: mastectomy for breast cancer. Early
Page 39 and 40: monitored for the development of po
Page 41 and 42: modality, and tumor stage distribut
Page 43 and 44: 26. Pain and other symptoms during
Page 45 and 46: 28. Coping, catastrophizing and chr
Page 47 and 48: surgical technique at the time of m
Page 49 and 50: 0.001), 0.315 cm +/- 1.27 at the an
Page 51 and 52: or heat and superficial incision is
Page 53 and 54: RecommendationsA. Preparation of th
Page 55 and 56: 3. Mangram AJ, Horan TC, Pearson ML
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Mild hypothermia increases blood lo
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Perioperative Normothermia to Reduc
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Priorities: Restoration of circulat
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than 1.5 times control values but f
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outcomes that may result from the u
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Preoperative Preparation of the Pat
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patients, or other patients who may
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Obstruction can occur at the level
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c. Administer face mask preoxygenat
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5. The use of exhaled carbon dioxid
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disorder) may occur after an episod
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undergoing general anesthesia, eith
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anesthesia awareness occurred in ea
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The current guidelines are actually
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o S - Strong Recommendation -Commit
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oSource control ASAP after successf
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oooWean steroids once vasopressors
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Mechanical ventilation of sepsis-in
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o CVVH offers easier management inh
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critically ill patient that are con
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Rivers E, Nguyen B, Havstad S, et a
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in survival of 7.6%. By the second
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parameters (gastric mucosal Pco2, s
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syndrome. We therefore conducted a
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Complications After Limb SalvageSur
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local tumor and to preserve as much
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femoral head to the center of the k
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4. Griffin AM, Parsons JA, Davis AM
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20. Roberts P, Chan D, Grimer RJ, e
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An infection can have disastrous co
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and facilitating reimplantation sur
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features of a two-stage revision is
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patients had an amputation. Two oth
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its main role is confined to ruling
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2. Capanna R, Morris HG, Campanacci
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21. Wilson MG, Kelley K, Thornhill
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39. Love C, Marwin SE, Tomas MB, Kr
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5. A systematic review of 25 RCT’
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(cefazolin or cefuroxime) or penici
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should be based on the isolates fro
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such as concomitant use of prophyla
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Surgical techniqueAdherence to meti
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2. Another small prospective random
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Antibiotic prophylaxis for dental a
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Antimicrobial Prophylaxis in Orthop
Page 148 and 149:
35. Tai CC, Nirvani AA, Holmes A, e
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53. Parker MJ, Roberts C. Closed su
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Vessel Related Issues in Sarcoma:Ev
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sequences may be of value. They cau
Page 156 and 157:
an excellent alternative to amputat
Page 158:
5. Hünerbein M, Hohenberger P, Str
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Oral IncompetenceOral competence is
Page 164 and 165:
flap is insensate and has no motor
Page 166 and 167:
16. R. Song, Y. Gao, Y. Song, Y. Yu
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The incidence is usually lower afte
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Late fibrotic phase: Attempted tiss
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Ref: A Lyons, N Ghazali/ British J
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17. Store G, Boysen M. Mandibular o
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amino acids, proteins and traces of
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RTOG, EORTC and CTCAE, version 3 fo
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difference in the disease related p
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References1. Bourhis J, Rosine D. R
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with head and neck cancer. N Engl J
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MucositisMucositis is an inflammato
Page 188 and 189:
Type of cancer: high risk for mucos
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Oral care protocol1. Brush all toot
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3. El-Sayed S, Nabid A, ShelleyW, e
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1) Recipient site problems- The maj
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estoration of vascular flow to tiss
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General Complications- Deep vein th
Page 200 and 201:
Nerve Injuries(Recurrent and Superi
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paramedian position, it will result
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along with its variations, and a me
Page 206 and 207:
anatomy as related to surgery of th
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Risk factorsCentral compartment (Le
Page 210 and 211:
Goal - To raise serum calcium level
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Pharyngocutaneous Fistula (PC Fistu
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Based on our institutional practice
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fistula: The Memorial University ex
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Risk factors (LOE-5)Patient factors
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oCircumferencial excision and inser
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y trauma or tumor, exposing the und
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Arytenoid cartilage is reported to
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Filntisis, G.A., et al. “Laryngea
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As high as 52% patients are detecte
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ManagementPostural exercisesDisorde
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References1) Objective assessment o
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Diagnosis Average time to hypothyro
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Management of Facial Nerve InjuryIn
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2. Interposition or cable graft (to
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Prevention of corneal exposure Tars
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flushing) and localized sweating (g
Page 244 and 245:
Other options :1. Intracutaneous in
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Shoulder Dysfunction or PainfulShou
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EMG studies on scapulo-humeral and
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Chyle Fistula after Neck Dissection
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Rationale:LCTs, which constitute 70
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CSF Leak after Craniofacial Resecti
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to the muscle to recreate the orbit
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Conservative treatmentIt is logical
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Complications Associated with use o
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Following is the example of hematol
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ooooooo direct interaction with the
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ooooointravenously over 15 minutes
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in most of the patients. The common
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Section — IIIRadiotherapyContribu
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nodes are involved or suspected to
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function. In general, with conventi
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like ultrasonography, CT scan, endo
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catheter passed through the anus in
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Acute symptoms usually subside seve
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granulocytopenia, thrombocytopenia
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adiation therapy), IMRT (intensity-
Page 287 and 288:
patients who have received radical
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ate expected in the standard popula
Page 292 and 293:
adjusting for competing causes of d
Page 294 and 295:
therapy (3D-CRT) and intensity modu
Page 296 and 297:
attributed to use of cisplatin base
Page 298 and 299:
Conclusion:Incidence of SMN is incr
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11. Travis LB, Fossa SD, Schonfeld
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adiation-related solid SMNs will in
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0.71, p
Page 306 and 307:
5.65%) within 45 years after a CNS
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adiation damage though supporting v
Page 310 and 311:
without calcification. Inflammation
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patients treated using the original
Page 314 and 315:
incidence of valvular thickening at
Page 316 and 317:
12. Hancock S, Hoppe R. Long-term c
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syndrome and bronchiolitis oblitera
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Darby SC, McGale P, Taylor CW, Peto
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undertaken, based on individual pat
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Pathophysiological Aspects:The func
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Symptoms: Symptoms related to pulmo
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Prevention of Pneumonitis and Lung
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genotyping analysis of single nucle
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Registry of Patients. We computed I
Page 334 and 335:
eceived elective nodal irradiation
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Int J Radiat Oncol Biol Phys. 1995
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worsening during the treatment shou
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Differential Diagnosis: This sign i
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Dose Incidence Comments Author>30 G
Page 344 and 345:
PET scan findings have been describ
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3. Pallis CA, Louis S, Morgan RL.:
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24. Abbatucci JS, Delozier T, Quint
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and summarized into specific recomm
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adequate. With the increasing use o
Page 354 and 355:
Complications are mainly described
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IQ decline is associated with sever
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activity’ of a person, essentiall
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development after brain tumor thera
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Highest relative risk of second can
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Suggested Reading:A) Neuropsycholog
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aseline. Male sex, longer symptomat
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number of patients. Cognition was p
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16 years, the corresponding value w
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15 of 20 (75%) subjects, endocrine
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OBJECTIVE: To assess cerebrovascula
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hypometabolism. Of the 17 patients
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10-20 months, with an average of 18
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Febrile NeutropeniaNeutropenia is w
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Approach to initial antibiotic use
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Known colonization with Penicillin/
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DocumentedinfectionsSuggesteddurati
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Zygomycosis and other mold infectio
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Overall risk Examples Febrile neutr
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Broad spectrum DOSE Spectrum Commen
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Page 398 and 399:
Page 400 and 401:
Role of G-CSF-Primary Prophylaxis:R
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Chemotherapy Induced Nausea andVomi
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Level I Level II Level III Level IV
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Types & doses of AntiemeticsDrug &
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supported by a meta-analysis, which
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and follow-up after treatment for n
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day 1; aprepitant and dexamethasone
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2-3: APR 80 mg every day) or a cont
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Late Effects in Childhood CancerSur
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to increase their awareness about l
Page 420 and 421:
Contd...Score2BStatement of consens
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6 Kurkure PA, Achrekar S, Uparkar U
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nonirradiated group did not differ
Page 426 and 427:
Gaslini Children’s Research Hospi
Page 428 and 429:
Our ACT model has 3 basic facets; p
Page 430 and 431:
The relative risk of developing TLS
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the excretion of uric acid and phos
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hyperuricemia (> 7.5 mg/dL), treatm
Page 436 and 437:
hydration, and the administration o
Page 438 and 439:
which the different drugs are admin
Page 440 and 441:
Table 2. Cairo-Bishop clinical Tumo
Page 442 and 443:
Table 4 Patient Stratification by R
Page 444 and 445:
Table 6 Management of Electrolyte A
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of TLS and improve the management o
Page 448 and 449:
4. Efficacy and safety of rasburica
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Pulmonary Toxicity of Antineoplasti
Page 452 and 453:
Though there are many chemotherapeu
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corticosteroids with variable respo
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Nephrotoxicity ofChemotherapeutic D
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associated with use of carbopltin c
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Table 2 Chemotherapeutics Requiring
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against ifosfamide nephrotoxicity.
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The incidence of mucositis involvin
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7. Obesity - Probably due to over d
Page 468 and 469:
conditioning treatment and for 3 da
Page 470 and 471:
References and Recommended Readings
Page 472 and 473:
metabolism for activity, cyclophosp
Page 474 and 475:
delays excretion and eventually res
Page 476 and 477:
Combination Chemotherapy:Combinatio
Page 478 and 479:
Vincristine: No dose reduction if b
Page 480 and 481:
19. Slichenmyer WJ, Rowinsky EK, Gr
Page 482 and 483:
AlopeciaCommon drugs causing alopec
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dependent, occurring from 8 days to
Page 486 and 487:
Cancer Induced Anemia (CIA)Introduc
Page 488 and 489:
system. There is an upregulation of
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time may represent increasing anemi
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(rHuEPO) whiles the other received
Page 494 and 495:
Table 3. Improvements in Hemoglobin
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2. Groopman JE, Itri LM. Chemothera
Page 498 and 499:
epoetin alfa versus oral iron or no
Page 500 and 501:
NOTES
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Guidelines for Complications of Cancer Treatment Vol VIII Part B

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