Guidelines for Complications of Cancer Treatment Vol VIII Part B

16 years, the corresponding value was 72 (range, 64–129).Of 20 evaluable patients, 14 (70%) had less than average IQsat baseline, even before starting radiotherapy. The verbal IQ,performance IQ, and full-scale IQ, as well as other cognitivescores, did not change significantly at the 6- and 24-monthfollow-up assessments for all patients. The memory quotientin older children and young adults was maintained at 6 and24 months after SCRT, with a mean value of 93 and 100,respectively, compared with a mean baseline value of 81 beforeRT. The mean anxiety score in children measured by the C1and C2 components of the State-Trait Anxiety Inventory forChildren (STAIC) was 48 and 40, respectively, which improvedsignificantly to mean values of 30 and 26, respectively, at the24-month follow-up assessment (p = 0.005). The meandepression score in patients >16 years old was 23 at baselineand had improved to 17 and 14 at the 6-month and 24-monthfollow-up assessments, respectively. Conclusion: Our datademonstrated neuropsychological impairment in a cohort ofyoung patients with benign and low-grade tumors even beforestarting radiotherapy. SCRT, however, did not result in anyadditional worsening. These encouraging results need to bevalidated in a study with a larger number of patients and longerfollow-up.6. Reduction of health status 7 years after addition ofchemotherapy to craniospinal irradiation formedulloblastoma: a follow-up study in PNET 3 trialsurvivors on behalf of the CCLG (formerlyUKCCSG).Bull KS, Spoudeas HA, Yadegarfar G, Kennedy CR; J ClinOncol. 2007 20;25(27):4239-45.PURPOSE: To compare quality of survival after craniospinalirradiation (CSI) alone with survival after CSI pluschemotherapy (CT) for medulloblastoma.361