Guidelines for Complications of Cancer Treatment Vol VIII Part B

Table 2. Cairo-Bishop clinical Tumor Lysis Syndrome (Definition and Grading)GradeComplication 0 1 2 3 4 5Creatinine * 1.5 x ULN 1.5 x ULN > 1.5-3.0 x ULN > 3.0-6.0 x ULN > 6.0 x ULN DeathCardiac None Intervention Non urgent Symptomatic Life-threatening Deatharrhythmia * not indicated medical and incompletely (eg, arrhythmiaintervention controlled associated withindicated medically or CHF, hypotension,controlled with syncope, shock)device (eg, defibrillator)Seizure * None — One brief generalized Seizure in which Seizure of any Deathseizure; seizure(s) well consciousness is kind which arecontrolled by altered; poorly prolonged,anticonvulsants controlled seizure repetitive oror infrequent focal motor disorder; with difficult to controlseizures not interfering breakthrough (eg, statuswith ADL generalized seizures epilepticus,despite medical intractableintervention epilepsy)NOTE. Laboratory tumor lysis syndrome and at least one clinical complication.Abbreviations: ULN, upper limit of normal; CHF, congestive heart failure; ADL, activities of daily living.*Not directly or probably attributable to therapeutic agent.If no institutional ULN is specified, age/sex ULN creatinine may be defined as follows: > 1 to < 12 years of age, both male and female, 61.6 μmol/L;12 to < 16 years, both male and female, 88 μmol/L; 16 years, female 105.6 μmol/L, male 114.4 μmol/L.431