Guidelines for Complications of Cancer Treatment Vol VIII Part B

Mild hypothermia increases blood loss and transfusionrequirements during total hip arthroplastyHarald Schmied, Andrea Kurz, Daniel I Sessler, SybilleKozek, Albert Reiter Lancet 1996;347:289-92.Background - In-vitro studies indicate that platelet functionand the coagulation cascade are impaired by hypothermia.However, the extent to which perioperative hypothermiainfluences bleeding during surgery remainsunknown.Accordingly, authors tested the hypothesis that mildhypothermia increases blood loss and allogeneic transfusionrequirements during hip arthroplasty.Methods - Blood loss and transfusion requirements wereevaluated in 60 patients undergoing primary, unilateral totalhip arthroplasties who were randomly assigned tonormothermia (final intraoperative core temperature36.6 ± 0.4 0 C or mild hypothermia (35.0 ± 0.5 0 C). Crystalloid,colloid, scavenged red cells, and allogeneic blood wereadministered by strict protocol.Findings - Intra- and postoperative blood loss was significantlygreater in the hypothermic patients: 2.2 ± 0.5 Lt vs 1.7 ±0.3)Lt, p