Guidelines for Complications of Cancer Treatment Vol VIII Part B

7. Obesity – Probably due to over dosing as a result offailure to adjust dosage to ideal body weight8. Genetic predisposition – some preliminary work suggestsa possibility that some individuals are more prone fordevelopment of mucositis than others.Prevention and treatment of mucositis anddiarrhea-Advancements in terminology and in the assessment of AM inpatients receiving cytoreductive cancer therapies have resultedin better patient management practices and enhanced drugdevelopment to reduce toxicity. Several attempts are inprogress to develop models for assessing risk of mucositis inany given patient. The Mucositis Study Group of theMultinational Association of Supportive Care in Cancer(MASCC) and the International Society for Oral Oncology(ISOO) have developed the guidelines based on availableevidence for prevention and treatment of chemotherapyassociated mucositis which were first published in 2004 andhave been updated in 2007.To prevent the development of oral mucositis followingstandard chemotherapy following methods have beensuggested -1. Basic oral care, its importance in maintaining mucosalhealth, integrity, and function is well accepted. Thepurpose of basic oral care is to reduce the impact of theoral microbial flora, reduce cancer therapy–relatedsymptoms of pain and bleeding, and prevent soft tissueinfections that may have systemic sequelae. In addition,maintenance of good oral hygiene will reduce the riskof dental complications, including caries and gingivitis.For these reasons, basic oral care is an importantcomponent of care of the patient with cancer The457