Guidelines for Complications of Cancer Treatment Vol VIII Part B

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3. Pallis CA, Louis S, Morgan RL.: Radiation myelopathy.Brain 1961;84:460–479.4. Rubin P, Constine LS, Fajardo LF. Overview:Late effectsof normal tissue (LENT) scoring system. Int J RadiatOncol Biol Phys 1995; 31:1041-1042.5. Jones A. Transient radiation myelopathy. Br J Radiol1964;37:727–744.6. Lhermitte J: Sur l’hypertrophie musculaire consecutiveaux lésions grave des nerfs peripherique: une observationnouvelle. Press Med 1918; 26:647. Fein DA, Marcus RB, Parsons JT, Mendenhall WM,Million RR. Lhermitte’s sign: incidence and treatmentvariables influencing risk after irradiation of the cervicalspinal cord. Int J Radiat Oncol Biol Phys1993;27(5):1029–1033.8. Lewanski CR, Sinclair JA, Stewart JS. Lhermitte’s signfollowing head and neck radiotherapy. Clin Oncol (RColl Radiol) 2000;12(2):98–103.9. Peterson K, Rosenblum MK, Powers JM, Alvord E,Walker RW,Posner JB. Effect of brain irradiation ondemyelinating lesions. Neurology. 993;43(10):2105–211210. Delatta JY, Rosenblum MK, Thaler HT, et al. A modelof radiation myelopathy in the rat. Pathology, regionalcapillary permeability changes and treatment withdexamethasone. Brain 1988;111:1319 – 1336.11. Reagan TJ, Thomas JE and Colby MY. Chronicprogressive radiation myelopathy. Journal of theAmerican Medical Association 1968; 203, 128-132.12. Schultheiss TE. Spinal cord radiation tolerance: doctrinevs. data. Int J Radiat Oncol Biol Phys 1994;30:735-6.13. Eicbhom HJ, Lessel A, Rotte KH Einfuss verschiedenerBestrahlungsrhythmen auf Tumor- und Normalgewebein vivo. Strahlentheraphie1972, 146:614-629.337
14. Abramson N, Cavanaugh PJ. Short course radiationtherapy in carcinoma of the lung. Radiology1973;108,685-68715. Miller RC, Aristizabal SA, Leith JT et al. Radiationmyelitis following a split course therapy for unresectablelung cancer. Int. J. Radiat. Oncol. Biol. Phys. 1977;2:179.16. Choi, NCH, Grillo HC, Gardiello M, et al. Basis fornew strategies in postoperative radiotherapy ofbronchogenic carcinoma. Int. J. Radiat. Oncol. Biol.Phys. 1980;6:31-35.17. Dische S, Martin WMC, Anderson P. Radiationmyelopathy in patients treated for carcinoma of thebronchus using a six fraction regime of radiotherapy.Br. J. Radiol 1981;29-35.18. Fitzgerald RH, Marks RD, Wallace KM.Chronicradiation myelitis. Radiology.1982; 144,609-612;.19. Emami B, Lyman J, Brown A et al. Tolerance of normaltissue to therapeutic irradiation. Int J Radiat Oncol BiolPhys 1991;21:109-22.20. Marcus RB, Million RR. The incidence of myelitis afterirradition of the cervical spinal cord. Int J Radiat OncolBiol Phys 1990; 19:3-8.21. McCunniff AJ, Liang MK. Radiation tolerance of thespinal cord. Int J Radiat Oncol Biol Phys 1990; 16:675-8.22. Reihold HS, Kaalen LG, Unger-Gils K. Radiationmyelopathy of the thoracic spinal cord. Int J Radiat OncolBiol Phys 1976;1:651-7.23. Van der Schueten E, Landuyt W, Ang KK, van der KogelAJ. From 2 Gy to 1 Gy per fraction: sparing effect in ratspinal cord? Int J Radiat Oncol Biol Phys 1988:14:297-300.338
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Guidelines forComplications ofCance
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Dedicated toAll our patients atThe
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Section IIHead & Neck 151Complicati
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PrefaceTreatment of cancer by vario
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Section — IGeneralContributorsDr.
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6. Complications after breast recon
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promises to reduce this risk of ser
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preceded by increased sensory hyper
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had significant lymphoedema. The fa
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2. Smoking as a risk factor for wou
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4. Preoperative core needle biopsy
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eduction mammoplasty, and axillary-
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postoperative wound infection follo
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ablative surgical treatment for car
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postoperative seroma formation usin
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dressing consisted of a circumferen
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mastectomies with axillary node cle
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mastectomy for breast cancer. Early
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monitored for the development of po
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modality, and tumor stage distribut
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26. Pain and other symptoms during
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28. Coping, catastrophizing and chr
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surgical technique at the time of m
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0.001), 0.315 cm +/- 1.27 at the an
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or heat and superficial incision is
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RecommendationsA. Preparation of th
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3. Mangram AJ, Horan TC, Pearson ML
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Mild hypothermia increases blood lo
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Perioperative Normothermia to Reduc
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Priorities: Restoration of circulat
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than 1.5 times control values but f
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outcomes that may result from the u
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Preoperative Preparation of the Pat
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patients, or other patients who may
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Obstruction can occur at the level
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c. Administer face mask preoxygenat
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5. The use of exhaled carbon dioxid
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disorder) may occur after an episod
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undergoing general anesthesia, eith
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anesthesia awareness occurred in ea
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The current guidelines are actually
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o S - Strong Recommendation -Commit
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oSource control ASAP after successf
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oooWean steroids once vasopressors
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Mechanical ventilation of sepsis-in
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o CVVH offers easier management inh
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critically ill patient that are con
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Rivers E, Nguyen B, Havstad S, et a
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in survival of 7.6%. By the second
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parameters (gastric mucosal Pco2, s
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syndrome. We therefore conducted a
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Complications After Limb SalvageSur
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local tumor and to preserve as much
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femoral head to the center of the k
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4. Griffin AM, Parsons JA, Davis AM
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20. Roberts P, Chan D, Grimer RJ, e
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An infection can have disastrous co
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and facilitating reimplantation sur
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features of a two-stage revision is
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patients had an amputation. Two oth
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its main role is confined to ruling
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2. Capanna R, Morris HG, Campanacci
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21. Wilson MG, Kelley K, Thornhill
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39. Love C, Marwin SE, Tomas MB, Kr
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5. A systematic review of 25 RCT’
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(cefazolin or cefuroxime) or penici
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should be based on the isolates fro
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such as concomitant use of prophyla
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Surgical techniqueAdherence to meti
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2. Another small prospective random
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Antibiotic prophylaxis for dental a
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Antimicrobial Prophylaxis in Orthop
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35. Tai CC, Nirvani AA, Holmes A, e
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53. Parker MJ, Roberts C. Closed su
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Vessel Related Issues in Sarcoma:Ev
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sequences may be of value. They cau
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an excellent alternative to amputat
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5. Hünerbein M, Hohenberger P, Str
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Oral IncompetenceOral competence is
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flap is insensate and has no motor
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16. R. Song, Y. Gao, Y. Song, Y. Yu
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The incidence is usually lower afte
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Late fibrotic phase: Attempted tiss
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Ref: A Lyons, N Ghazali/ British J
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17. Store G, Boysen M. Mandibular o
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amino acids, proteins and traces of
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RTOG, EORTC and CTCAE, version 3 fo
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difference in the disease related p
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References1. Bourhis J, Rosine D. R
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with head and neck cancer. N Engl J
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MucositisMucositis is an inflammato
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Type of cancer: high risk for mucos
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Oral care protocol1. Brush all toot
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3. El-Sayed S, Nabid A, ShelleyW, e
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1) Recipient site problems- The maj
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estoration of vascular flow to tiss
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General Complications- Deep vein th
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Nerve Injuries(Recurrent and Superi
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paramedian position, it will result
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along with its variations, and a me
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anatomy as related to surgery of th
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Risk factorsCentral compartment (Le
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Goal - To raise serum calcium level
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Pharyngocutaneous Fistula (PC Fistu
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Based on our institutional practice
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fistula: The Memorial University ex
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Risk factors (LOE-5)Patient factors
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oCircumferencial excision and inser
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y trauma or tumor, exposing the und
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Arytenoid cartilage is reported to
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Filntisis, G.A., et al. “Laryngea
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As high as 52% patients are detecte
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ManagementPostural exercisesDisorde
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References1) Objective assessment o
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Diagnosis Average time to hypothyro
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Management of Facial Nerve InjuryIn
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2. Interposition or cable graft (to
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Prevention of corneal exposure Tars
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flushing) and localized sweating (g
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Other options :1. Intracutaneous in
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Shoulder Dysfunction or PainfulShou
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EMG studies on scapulo-humeral and
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Chyle Fistula after Neck Dissection
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Rationale:LCTs, which constitute 70
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CSF Leak after Craniofacial Resecti
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to the muscle to recreate the orbit
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Conservative treatmentIt is logical
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Complications Associated with use o
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Following is the example of hematol
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ooooooo direct interaction with the
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ooooointravenously over 15 minutes
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in most of the patients. The common
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Section — IIIRadiotherapyContribu
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nodes are involved or suspected to
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function. In general, with conventi
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like ultrasonography, CT scan, endo
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catheter passed through the anus in
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Acute symptoms usually subside seve
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granulocytopenia, thrombocytopenia
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adiation therapy), IMRT (intensity-
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patients who have received radical
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ate expected in the standard popula
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adjusting for competing causes of d
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therapy (3D-CRT) and intensity modu
Page 296 and 297: attributed to use of cisplatin base
Page 298 and 299: Conclusion:Incidence of SMN is incr
Page 300 and 301: 11. Travis LB, Fossa SD, Schonfeld
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Page 306 and 307: 5.65%) within 45 years after a CNS
Page 308 and 309: adiation damage though supporting v
Page 310 and 311: without calcification. Inflammation
Page 312 and 313: patients treated using the original
Page 314 and 315: incidence of valvular thickening at
Page 316 and 317: 12. Hancock S, Hoppe R. Long-term c
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Page 320 and 321: Darby SC, McGale P, Taylor CW, Peto
Page 322 and 323: undertaken, based on individual pat
Page 324 and 325: Pathophysiological Aspects:The func
Page 326 and 327: Symptoms: Symptoms related to pulmo
Page 328 and 329: Prevention of Pneumonitis and Lung
Page 330 and 331: genotyping analysis of single nucle
Page 332 and 333: Registry of Patients. We computed I
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Page 336 and 337: Int J Radiat Oncol Biol Phys. 1995
Page 338 and 339: worsening during the treatment shou
Page 340 and 341: Differential Diagnosis: This sign i
Page 342 and 343: Dose Incidence Comments Author>30 G
Page 344 and 345: PET scan findings have been describ
Page 348 and 349: 24. Abbatucci JS, Delozier T, Quint
Page 350 and 351: and summarized into specific recomm
Page 352 and 353: adequate. With the increasing use o
Page 354 and 355: Complications are mainly described
Page 356 and 357: IQ decline is associated with sever
Page 358 and 359: activity’ of a person, essentiall
Page 360 and 361: development after brain tumor thera
Page 362 and 363: Highest relative risk of second can
Page 364 and 365: Suggested Reading:A) Neuropsycholog
Page 366 and 367: aseline. Male sex, longer symptomat
Page 368 and 369: number of patients. Cognition was p
Page 370 and 371: 16 years, the corresponding value w
Page 372 and 373: 15 of 20 (75%) subjects, endocrine
Page 374 and 375: OBJECTIVE: To assess cerebrovascula
Page 376 and 377: hypometabolism. Of the 17 patients
Page 378: 10-20 months, with an average of 18
Page 382 and 383: Febrile NeutropeniaNeutropenia is w
Page 384 and 385: Approach to initial antibiotic use
Page 386 and 387: Known colonization with Penicillin/
Page 388 and 389: DocumentedinfectionsSuggesteddurati
Page 390 and 391: Zygomycosis and other mold infectio
Page 392 and 393: Overall risk Examples Febrile neutr
Page 394 and 395: Broad spectrum DOSE Spectrum Commen
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Broad spectrum DOSE Spectrum Commen
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Broad spectrum DOSE Spectrum Commen
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Role of G-CSF-Primary Prophylaxis:R
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Chemotherapy Induced Nausea andVomi
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Level I Level II Level III Level IV
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Types & doses of AntiemeticsDrug &
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supported by a meta-analysis, which
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and follow-up after treatment for n
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day 1; aprepitant and dexamethasone
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2-3: APR 80 mg every day) or a cont
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Late Effects in Childhood CancerSur
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to increase their awareness about l
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Contd...Score2BStatement of consens
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6 Kurkure PA, Achrekar S, Uparkar U
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nonirradiated group did not differ
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Gaslini Children’s Research Hospi
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Our ACT model has 3 basic facets; p
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The relative risk of developing TLS
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the excretion of uric acid and phos
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hyperuricemia (> 7.5 mg/dL), treatm
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hydration, and the administration o
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which the different drugs are admin
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Table 2. Cairo-Bishop clinical Tumo
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Table 4 Patient Stratification by R
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Table 6 Management of Electrolyte A
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of TLS and improve the management o
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4. Efficacy and safety of rasburica
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Pulmonary Toxicity of Antineoplasti
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Though there are many chemotherapeu
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corticosteroids with variable respo
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Nephrotoxicity ofChemotherapeutic D
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associated with use of carbopltin c
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Table 2 Chemotherapeutics Requiring
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against ifosfamide nephrotoxicity.
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The incidence of mucositis involvin
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7. Obesity - Probably due to over d
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conditioning treatment and for 3 da
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References and Recommended Readings
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metabolism for activity, cyclophosp
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delays excretion and eventually res
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Combination Chemotherapy:Combinatio
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Vincristine: No dose reduction if b
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19. Slichenmyer WJ, Rowinsky EK, Gr
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AlopeciaCommon drugs causing alopec
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dependent, occurring from 8 days to
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Cancer Induced Anemia (CIA)Introduc
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system. There is an upregulation of
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time may represent increasing anemi
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(rHuEPO) whiles the other received
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Table 3. Improvements in Hemoglobin
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2. Groopman JE, Itri LM. Chemothera
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epoetin alfa versus oral iron or no
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NOTES
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