Guidelines for Complications of Cancer Treatment Vol VIII Part B

Dermatologic Toxicity of AntineoplasticTherapyThe function of human skin to serve as a protector, a sensor, atemperature regulator, and an overall window into the body’sever-changing states is amazing. The unique ability of the skinto proliferate and repair itself rapidly makes it a commonincidental target for chemotherapeutic drugs. The mostcommon reaction are listed in Table 1 1 . Because skin reactionscan range from benign to life threatening, the presence of acutaneous complication does not necessarily require cessationof the drug.472Table 1Major cutaneous reaction patterns associated withchemotherapy areAlopeciaAcral erythemaRadiation RecallRadiation EnhancementPhotosensitivityHyperpigmentationNail changesHypersensitivity