Marie Curie Actions: Inspiring Researchers - Imdea

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TARGETING PCD IN PDA <strong>Marie</strong> <strong>Curie</strong> grant lured Miquel Vila back to Europe from the United States. He is now in Spain investigating newtherapies for Parkinson’s disease, one of the most serious degenerative conditions affecting the brain. And he hasestablished his own research group to help him.
Brain gain to fightbrain drainA neurodegenerative disease is a condition in which the vital,and for now irreplaceable, cells of the brain and spinal cord,known as neurons, die. The two most common are Alzheimer’sand Parkinson’s disease, both of which share a commontrait: proteins collect and form deposits in internal organs,interfering with normal cellular function, sometimes lethally.Parkinson’s disease is the second most commonneurodegenerative disorder after Alzheimer’s dementia.More than 1.2 million Europeans – mostly aged between 55and 75 – live with the consequences of this progressive disease,according to the European Parkinson’s Disease Association(EPDA). The disease is not only devastating for the sufferer,who gradually loses control of his or her body, but also forfriends and family who watch this happen.Scientists do not yet know what causes the condition, althoughit has been established that genetic factors, toxins and headtraumas are the cause in a minority of cases.Parkinson’s is very diffi cult to diagnose in its early stages –something that is not helped by the way in which symptomsvary from person to person. The development and progressionof the disease also hinder diagnosis. Many patients will suffertremors, slowness of movement, rigidity and poor balance,not to mention cognitive and mood disturbances. Thesesymptoms can be explained by a dramatic loss of dopamineproducingneurons, which in turn leads to a shortage of thisneurotransmitter in the brain of affected patients.Seeking a cureDespite long years of research, there remains no known curefor Parkinson’s. Instead, treatment focuses on alleviatingthe symptoms, which doctors do by compensating for thedopamine defi ciencies in the brain. As dopamine cannot crossDopaminergic neuron: this type of neuron degenerates preferentially in Parkinson’s disease.217
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EUROPEANCOMMISSIONEuropeanResearch
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EUROPEAN COMMISSIONINSPIRING RESEAR
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Marie Curie Actions: Inspiring Rese
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ContentsIntroduction . . . . . . .
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WORLDWIDE RESEARCH . . . . . . . .
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within the best European research g
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Cross-border cooperation is the cor
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The Marie Curie programme seeks to
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AQUACHEMWater is life. It is key to
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ground for early-stage and experien
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CARBIOCarbon nanotubes are the epit
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e chemically modifi ed to further e
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CATALYSTS TOMOGRAPHY‘Everything b
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included a specimen holder inserted
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CRONUS-EUThe Earth is under attack:
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led to an unprecedented ability to
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HETEROLICSThe days of grainy graphi
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Other researchers from Ural State T
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HYDROGEN 1S-2SAccurate clocks are c
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more accurate. Such a clock could b
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RAPTOR ECOTOXFears over species los
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in Sicily, as well as rock climbers
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SMARTEverything about this material
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Development scheme as a chance to m
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SPATSTATHow can statistical analysi
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Hristopulos. There are two categori
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TRACKSResearch within the Tracks pr
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intellectual property issues and th
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Marie Curie Fellowships act as a sp
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The seeds of a budding career are p
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ARTEMISUnderstanding nature at its
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network institutes have allowed the
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BIOMEMA membrane is a layer of mate
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Mighty Mini-MBABut Biomem also step
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COMODEWhen consumers buy a new coff
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with computer-aided design (CAD) to
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COOPERATIVE BREEDINGCan our sibling
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mammals. Other analyses of cooperat
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CSIMHVALVESImagine being able to un
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could be used to describe how carti
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GLUESDr Markus Reichstein is a ‘r
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The carbon cycle begins with plants
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INTERDECHow an organism develops de
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The heart of the matterThe PhD Fell
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KAPROWThe theory of democratic peac
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necessary to stop it.’ If we are
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NASCENTAlthough nanotechnology deal
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The network focuses on the developm
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NEUROEMPATHYEver sense a chill runn
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Mapping empathySince the 1890s, it
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© stock.xchngOESTROGEN RECEPTORThe
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says Dr López-Béjar. Underlining
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PAPHOSIn 1870, Jules Verne wrote ab
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Minuscule communities under the sea
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PENELOPEPenelope, the wife of Ulyss
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Training and travelFor the Fellows,
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PUMPING UP THE HEARTMany researcher
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iochemical reactions take place in
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SEMEAIOutside the obvious green job
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suited to some companies than to ot
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Increasing our knowledge of the uni
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Everybody benefi ts from knowledge
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CABMarie Curie Fellows working unde
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The project achieved some major mil
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ENZYMATEnzymes are biomolecules tha
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eports. And the industry seems to s
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NUCSYSComplex organisms such as hum
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Integrating the ‘-omics’Nuclear
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TARGET-BREASTThe emotional turmoil
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diagnostics within an industrial en
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TEAMOHOLICAlthough it deals with an
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Dream teamAs its name suggests, Tea
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Women researchers have brought majo
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more likely to leave once they are
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AQUABASEToday, an increasingly comp
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‘With C14 isotopes, we can track
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DRUG-DISCOVERYDuring her two-year M
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chemically in various fashions. The
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EARA-ESTThe European Association fo
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‘Our programme is founded on the
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GLADNETAccurate data about the qual
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Working with industryIn addition to
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MIGRANT CHILDRENImmigration has bec
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Page 170 and 171: NANBIOPTICOne of the most exciting
Page 172 and 173: Marie Curie support allowed me, amo
Page 174 and 175: NANOMATCHDeveloping new and more ef
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Page 178 and 179: Europe is increasingly retaining it
Page 180 and 181: well as the researcher’s scientif
Page 182 and 183: ADAPTUNPREDICTThe Marie Curie progr
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Page 190 and 191: ELSAQUINTANA-NCSCSFor Spanish pharm
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Page 194 and 195: EXNER_BORISOVMany modern devices an
Page 196 and 197: chips, for instance. ‘Of course,
Page 198 and 199: HIVOXFORDIn late 2006, five Bulgari
Page 200 and 201: that the accused medical personnel
Page 202 and 203: © stock.xchngMARINE MAGNETISMIsn
Page 204 and 205: aeolian dust. The second traces dus
Page 206 and 207: MODPAPThe Modpap project has delive
Page 208 and 209: According to Dr Macpherson, Dr Pill
Page 210 and 211: NANOSWITCHIt calls to mind a scene
Page 212 and 213: ‘Throughout their journey, the na
Page 214 and 215: PIPKIGKOOne in every 700 babies bor
Page 216 and 217: focal adhesions of specifi c protei
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Page 222 and 223: Science completely shapes the way w
Page 224 and 225: as labs and microscopes in order to
Page 226 and 227: BCRThe moon holds a strange fascina
Page 228 and 229: A new perspective on chronobiologyT
Page 230 and 231: © stock.xchngBIMORESolar energy is
Page 232 and 233: convert CO 2into a reduced carbon b
Page 234 and 235: CENS-CMAAs the Estonian coastline c
Page 236 and 237: The research visitors provided valu
Page 238 and 239: FLOODSVery few of us now question t
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Page 242 and 243: NANOMAG-LABThese days, the average
Page 244 and 245: What is more, Nanomag-Lab fostered
Page 246 and 247: NEPHILID SPIDERSSlovenian scientist
Page 248 and 249: One simple strategy involves the ma
Page 250 and 251: © stock.xchngWISEThe 32 countries
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Page 254 and 255: The quest for knowledge is a univer
Page 256 and 257: Global partnershipsBy opening up Eu
Page 258 and 259: ATTACCOnly one in a million is affe
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Page 262 and 263: BIOSEBOut in the middle of nowhere,
Page 264 and 265: free discussion evenings, and staff
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might contribute to the effect. ‘
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CAVEOLINSEvery breath becomes a whe
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‘Our research revealed that the c
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EPISCONThe conservation and preserv
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able to follow whatever course my c
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© stock.xchngPARSEMUnder the Marie
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The research objectives of Parsem w
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NEURAL CIRCUITBlind mice can now se
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An international effortRecognising
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Being able to simultaneously build
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A number of initiatives can be impl
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EURYTHRONYoung researchers working
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Flexible work environmentThe resear
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INNATE IMMUNITYThe Innate Immunity
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more cytokines. Normally, this feed
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NLRS IN IMMUNITYMore than a million
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organisms and to shed light on the
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ZSN-PHD PROGRAMMEIt takes talent, t
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eview.’ The ZSN has also encourag
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The Marie Curie Actions are founded
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All this is designed to achieve one
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On soft groundWhen faced with groun
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shared through annual workshops, in
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And the Oscar goesto...When your ci
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this, the software can take charact
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Recreating the earlyuniverseParticl
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Imagination equals discoveryDr Mast
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Rock-solid researchinto shaky groun
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existing ones with international sc
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Wireless wisdomComputer networks ha
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he recently received a Young Invest
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It’s elementary:of quarks, lepton
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A real career boostAdding into the
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Spin,little electron, spinAt the ba
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The armamentarium for new researchT
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Putting an endto cluster bombtraged
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elations, law and politics from the
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Inspiring changein the wider resear
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343
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Good vibrationsThe Marie Curie Acti
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to signifi cantly change the way Ph
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MuTra: a labour of loveWhile the ge
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sites in Berlin, Munich, Zürich, S
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The Marie Curie Actions are widely
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Marie Curie Actions: Inspiring Researchers - Imdea

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