Marie Curie Actions: Inspiring Researchers - Imdea

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INNATE IMMUNITYThe Innate Immunity project carried out key research in the fight against infectious disease. And to do soeffectively, it relied on the combined talents of all its team members. When Adelheid Cerwenka’s baby was born,creative solutions were found to enable her to reconcile her goals both as a mother and as a project leader.
Success on two fronts:combining researchcareer and family lifeHuman beings are constantly exposed to infectious agents, mostof which the immune system helps us to resist. One arm of theimmune system is the innate or non-specifi c immune system,our fi rst line of defence against invading organisms. It carriesout a crucial protective function using both cellular and solubleagents. The innate immune system also has anatomical featuresthat function as barriers to infection.Mustering new allies in the fight againstinfection‘The aim of the Innate Immunity project was to identify novelmolecular players in innate immune pathways, using functionalgenomics and biochemical approaches,’ explains Dr Cerwenka,the project’s group leader.The innate immune system has several genetically encodedreceptor families – biological molecules to which a drug binds –that interact during the detection and elimination of pathogens.The toll-like receptor (TLR) family recognises a diverse group ofmolecules that have remained largely unchanged throughoutevolution. The engagement of these receptors results inpro-infl ammatory signalling. Another family of innate immunereceptors, known as triggering receptors expressed on myeloidcells (TREMs), are able to alter the downstream signallingpotential of the TLR molecules.Molecular pathways are sequences of actions by moleculeswithin a cell, generally involved in some aspect of cell functioning.Most experts agree that components of a particular molecularpathway, the TREM-1/DAP12 pathway, could provide a promisingtherapeutic strategy for the treatment of infl ammatory diseases.‘The TREM-1/DAP12 pathway that we were mainly interestedin activates myeloid cells to produce infl ammatory cytokinesand amplifi es experimentally induced septic shock,’ explainsDr Cerwenka.When the immune system is fi ghting pathogens, cytokinessignal immune cells to travel to the site of infection. In addition,cytokines activate those cells, stimulating them to produce<strong>Marie</strong> <strong>Curie</strong> Fellows at the German Cancer Research Centre293
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EUROPEANCOMMISSIONEuropeanResearch
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EUROPEAN COMMISSIONINSPIRING RESEAR
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Marie Curie Actions: Inspiring Rese
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ContentsIntroduction . . . . . . .
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WORLDWIDE RESEARCH . . . . . . . .
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within the best European research g
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Cross-border cooperation is the cor
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The Marie Curie programme seeks to
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AQUACHEMWater is life. It is key to
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ground for early-stage and experien
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CARBIOCarbon nanotubes are the epit
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e chemically modifi ed to further e
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CATALYSTS TOMOGRAPHY‘Everything b
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included a specimen holder inserted
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CRONUS-EUThe Earth is under attack:
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led to an unprecedented ability to
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HETEROLICSThe days of grainy graphi
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Other researchers from Ural State T
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HYDROGEN 1S-2SAccurate clocks are c
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more accurate. Such a clock could b
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RAPTOR ECOTOXFears over species los
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in Sicily, as well as rock climbers
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SMARTEverything about this material
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Development scheme as a chance to m
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SPATSTATHow can statistical analysi
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Hristopulos. There are two categori
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TRACKSResearch within the Tracks pr
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intellectual property issues and th
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Marie Curie Fellowships act as a sp
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The seeds of a budding career are p
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ARTEMISUnderstanding nature at its
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network institutes have allowed the
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BIOMEMA membrane is a layer of mate
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Mighty Mini-MBABut Biomem also step
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COMODEWhen consumers buy a new coff
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with computer-aided design (CAD) to
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COOPERATIVE BREEDINGCan our sibling
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mammals. Other analyses of cooperat
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CSIMHVALVESImagine being able to un
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could be used to describe how carti
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GLUESDr Markus Reichstein is a ‘r
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The carbon cycle begins with plants
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INTERDECHow an organism develops de
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The heart of the matterThe PhD Fell
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KAPROWThe theory of democratic peac
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necessary to stop it.’ If we are
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NASCENTAlthough nanotechnology deal
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The network focuses on the developm
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NEUROEMPATHYEver sense a chill runn
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Mapping empathySince the 1890s, it
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© stock.xchngOESTROGEN RECEPTORThe
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says Dr López-Béjar. Underlining
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PAPHOSIn 1870, Jules Verne wrote ab
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Minuscule communities under the sea
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PENELOPEPenelope, the wife of Ulyss
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Training and travelFor the Fellows,
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PUMPING UP THE HEARTMany researcher
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iochemical reactions take place in
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SEMEAIOutside the obvious green job
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suited to some companies than to ot
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Increasing our knowledge of the uni
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Everybody benefi ts from knowledge
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CABMarie Curie Fellows working unde
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The project achieved some major mil
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ENZYMATEnzymes are biomolecules tha
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eports. And the industry seems to s
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NUCSYSComplex organisms such as hum
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Integrating the ‘-omics’Nuclear
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TARGET-BREASTThe emotional turmoil
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diagnostics within an industrial en
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TEAMOHOLICAlthough it deals with an
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Dream teamAs its name suggests, Tea
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Women researchers have brought majo
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more likely to leave once they are
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AQUABASEToday, an increasingly comp
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‘With C14 isotopes, we can track
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DRUG-DISCOVERYDuring her two-year M
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chemically in various fashions. The
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EARA-ESTThe European Association fo
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‘Our programme is founded on the
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GLADNETAccurate data about the qual
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Working with industryIn addition to
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MIGRANT CHILDRENImmigration has bec
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Ireland possesses a category of mig
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NANBIOPTICOne of the most exciting
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Marie Curie support allowed me, amo
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NANOMATCHDeveloping new and more ef
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‘The ombudswoman is used quite fr
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Europe is increasingly retaining it
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well as the researcher’s scientif
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ADAPTUNPREDICTThe Marie Curie progr
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we understand the consequences bett
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© stock.xchngCSS-OMICSStress is a
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A key part of her research was to f
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ELSAQUINTANA-NCSCSFor Spanish pharm
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The cancer stem cell hypothesis pre
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EXNER_BORISOVMany modern devices an
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chips, for instance. ‘Of course,
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HIVOXFORDIn late 2006, five Bulgari
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that the accused medical personnel
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© stock.xchngMARINE MAGNETISMIsn
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aeolian dust. The second traces dus
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MODPAPThe Modpap project has delive
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According to Dr Macpherson, Dr Pill
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NANOSWITCHIt calls to mind a scene
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‘Throughout their journey, the na
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PIPKIGKOOne in every 700 babies bor
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focal adhesions of specifi c protei
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TARGETING PCD IN PDA Marie Curie gr
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the blood-brain barrier, the precur
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Science completely shapes the way w
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as labs and microscopes in order to
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BCRThe moon holds a strange fascina
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A new perspective on chronobiologyT
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© stock.xchngBIMORESolar energy is
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convert CO 2into a reduced carbon b
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CENS-CMAAs the Estonian coastline c
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The research visitors provided valu
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FLOODSVery few of us now question t
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The hunting ground for this preciou
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NANOMAG-LABThese days, the average
Page 244 and 245: What is more, Nanomag-Lab fostered
Page 246 and 247: NEPHILID SPIDERSSlovenian scientist
Page 248 and 249: One simple strategy involves the ma
Page 250 and 251: © stock.xchngWISEThe 32 countries
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Page 254 and 255: The quest for knowledge is a univer
Page 256 and 257: Global partnershipsBy opening up Eu
Page 258 and 259: ATTACCOnly one in a million is affe
Page 260 and 261: nutrients and ensures blood supply
Page 262 and 263: BIOSEBOut in the middle of nowhere,
Page 264 and 265: free discussion evenings, and staff
Page 266 and 267: CAUSE KIDNEY DAMAGEA potentially de
Page 268 and 269: might contribute to the effect. ‘
Page 270 and 271: CAVEOLINSEvery breath becomes a whe
Page 272 and 273: ‘Our research revealed that the c
Page 274 and 275: EPISCONThe conservation and preserv
Page 276 and 277: able to follow whatever course my c
Page 278 and 279: © stock.xchngPARSEMUnder the Marie
Page 280 and 281: The research objectives of Parsem w
Page 282 and 283: NEURAL CIRCUITBlind mice can now se
Page 284 and 285: An international effortRecognising
Page 286 and 287: Being able to simultaneously build
Page 288 and 289: A number of initiatives can be impl
Page 290 and 291: EURYTHRONYoung researchers working
Page 292 and 293: Flexible work environmentThe resear
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Page 298 and 299: NLRS IN IMMUNITYMore than a million
Page 300 and 301: organisms and to shed light on the
Page 302 and 303: ZSN-PHD PROGRAMMEIt takes talent, t
Page 304 and 305: eview.’ The ZSN has also encourag
Page 306 and 307: The Marie Curie Actions are founded
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Page 311 and 312: On soft groundWhen faced with groun
Page 313 and 314: shared through annual workshops, in
Page 315 and 316: And the Oscar goesto...When your ci
Page 317 and 318: this, the software can take charact
Page 319 and 320: Recreating the earlyuniverseParticl
Page 321 and 322: Imagination equals discoveryDr Mast
Page 323 and 324: Rock-solid researchinto shaky groun
Page 325 and 326: existing ones with international sc
Page 327 and 328: Wireless wisdomComputer networks ha
Page 329 and 330: he recently received a Young Invest
Page 331 and 332: It’s elementary:of quarks, lepton
Page 333 and 334: A real career boostAdding into the
Page 335 and 336: Spin,little electron, spinAt the ba
Page 337 and 338: The armamentarium for new researchT
Page 339 and 340: Putting an endto cluster bombtraged
Page 341 and 342: elations, law and politics from the
Page 343 and 344: Inspiring changein the wider resear
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343
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Good vibrationsThe Marie Curie Acti
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to signifi cantly change the way Ph
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MuTra: a labour of loveWhile the ge
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sites in Berlin, Munich, Zürich, S
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The Marie Curie Actions are widely
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Marie Curie Actions: Inspiring Researchers - Imdea

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