Marie Curie Actions: Inspiring Researchers - Imdea

Recommendations

Info

ATTACCOnly one in a million is affected, but the prognosis for these sufferers is far from good. Five years after the initial diagnosis,60 % of those with adrenocortical carcinoma lose their battle with the illness. <strong>Marie</strong> <strong>Curie</strong> Fellow Martin Fassnacht soughtto improve the chances of survival for people with this highly malignant adrenal cancer – and succeeded.
Attacking the tumourfrom withinAdrenocortical carcinoma – or ACC – affects the adrenal gland,a small organ close to the kidneys. It produces a variety ofhormones, including the stress hormone cortisol. Many ACCpatients – 60 to 70 % – show exceedingly high levels of particularhormones. In female patients this can lead to the developmentof male features, or in children, precocious puberty, amongother symptoms. ‘This is often the reason why they go to thedoctor, and then the disease is detected,’ says Dr Fassnacht.‘In other patients, it’s just the sheer size of the tumour. Themedium size is about 12 cm, but the organ itself is only 2 or3 cm in size. And some of our patients have tumours that growto be 20, 30 or even 40 cm, which certainly causes problemsby itself. But the majority have hormonal problems.’But what comes after the diagnosis? Unlike many other,more common cancers, ACC did not have an establisheddiagnostic or therapeutic approach until a few years ago. Andthere was no great interest from the pharmaceutical industryin studying the disease either because it is too rare. Attitudesseem to be changing now, thanks in part to the work doneby Dr Fassnacht during the ATTACC project, as well as hiscounterparts worldwide.Cutting off the tumour’s lifelinesDr Fassnacht took a two-fold approach in his studies at DukeUniversity in the United States and his home institution, theBayerische Julius-Maximilians-Universität in Würzburg, Germany:immunotherapy, on the one hand, and targeting the tumourstroma on the other. In immunotherapy, doctors try to stimulatethe patient’s immune system and make it attack and destroy thecancer cells, much like it would a virus.The antistromal strategy attempts to cut the tumour’s lifeline:‘Tumour stroma are the cells in a tumour which aren’t actuallytumour cells – the benign, normal cells,’ Dr Fassnacht explains.The stroma cells form the interface between malignant tumourcells and the normal host tissue; this provides the tumour withMicroscopic imaging of an adrenocortical carcinoma using immunofluorescence© M. Fassnacht, University of Würzburg, Germany257
Page 1 and 2:
EUROPEANCOMMISSIONEuropeanResearch
Page 3 and 4:
EUROPEAN COMMISSIONINSPIRING RESEAR
Page 5 and 6:
Marie Curie Actions: Inspiring Rese
Page 7 and 8:
ContentsIntroduction . . . . . . .
Page 9:
WORLDWIDE RESEARCH . . . . . . . .
Page 12 and 13:
within the best European research g
Page 14 and 15:
Cross-border cooperation is the cor
Page 16 and 17:
The Marie Curie programme seeks to
Page 18 and 19:
AQUACHEMWater is life. It is key to
Page 20 and 21:
ground for early-stage and experien
Page 22 and 23:
CARBIOCarbon nanotubes are the epit
Page 24 and 25:
e chemically modifi ed to further e
Page 26 and 27:
CATALYSTS TOMOGRAPHY‘Everything b
Page 28 and 29:
included a specimen holder inserted
Page 30 and 31:
CRONUS-EUThe Earth is under attack:
Page 32 and 33:
led to an unprecedented ability to
Page 34 and 35:
HETEROLICSThe days of grainy graphi
Page 36 and 37:
Other researchers from Ural State T
Page 38 and 39:
HYDROGEN 1S-2SAccurate clocks are c
Page 40 and 41:
more accurate. Such a clock could b
Page 42 and 43:
RAPTOR ECOTOXFears over species los
Page 44 and 45:
in Sicily, as well as rock climbers
Page 46 and 47:
SMARTEverything about this material
Page 48 and 49:
Development scheme as a chance to m
Page 50 and 51:
SPATSTATHow can statistical analysi
Page 52 and 53:
Hristopulos. There are two categori
Page 54 and 55:
TRACKSResearch within the Tracks pr
Page 56 and 57:
intellectual property issues and th
Page 58 and 59:
Marie Curie Fellowships act as a sp
Page 60 and 61:
The seeds of a budding career are p
Page 62 and 63:
ARTEMISUnderstanding nature at its
Page 64 and 65:
network institutes have allowed the
Page 66 and 67:
BIOMEMA membrane is a layer of mate
Page 68 and 69:
Mighty Mini-MBABut Biomem also step
Page 70 and 71:
COMODEWhen consumers buy a new coff
Page 72 and 73:
with computer-aided design (CAD) to
Page 74 and 75:
COOPERATIVE BREEDINGCan our sibling
Page 76 and 77:
mammals. Other analyses of cooperat
Page 78 and 79:
CSIMHVALVESImagine being able to un
Page 80 and 81:
could be used to describe how carti
Page 82 and 83:
GLUESDr Markus Reichstein is a ‘r
Page 84 and 85:
The carbon cycle begins with plants
Page 86 and 87:
INTERDECHow an organism develops de
Page 88 and 89:
The heart of the matterThe PhD Fell
Page 90 and 91:
KAPROWThe theory of democratic peac
Page 92 and 93:
necessary to stop it.’ If we are
Page 94 and 95:
NASCENTAlthough nanotechnology deal
Page 96 and 97:
The network focuses on the developm
Page 98 and 99:
NEUROEMPATHYEver sense a chill runn
Page 100 and 101:
Mapping empathySince the 1890s, it
Page 102 and 103:
© stock.xchngOESTROGEN RECEPTORThe
Page 104 and 105:
says Dr López-Béjar. Underlining
Page 106 and 107:
PAPHOSIn 1870, Jules Verne wrote ab
Page 108 and 109:
Minuscule communities under the sea
Page 110 and 111:
PENELOPEPenelope, the wife of Ulyss
Page 112 and 113:
Training and travelFor the Fellows,
Page 114 and 115:
PUMPING UP THE HEARTMany researcher
Page 116 and 117:
iochemical reactions take place in
Page 118 and 119:
SEMEAIOutside the obvious green job
Page 120 and 121:
suited to some companies than to ot
Page 122 and 123:
Increasing our knowledge of the uni
Page 124 and 125:
Everybody benefi ts from knowledge
Page 126 and 127:
CABMarie Curie Fellows working unde
Page 128 and 129:
The project achieved some major mil
Page 130 and 131:
ENZYMATEnzymes are biomolecules tha
Page 132 and 133:
eports. And the industry seems to s
Page 134 and 135:
NUCSYSComplex organisms such as hum
Page 136 and 137:
Integrating the ‘-omics’Nuclear
Page 138 and 139:
TARGET-BREASTThe emotional turmoil
Page 140 and 141:
diagnostics within an industrial en
Page 142 and 143:
TEAMOHOLICAlthough it deals with an
Page 144 and 145:
Dream teamAs its name suggests, Tea
Page 146 and 147:
Women researchers have brought majo
Page 148 and 149:
more likely to leave once they are
Page 150 and 151:
AQUABASEToday, an increasingly comp
Page 152 and 153:
‘With C14 isotopes, we can track
Page 154 and 155:
DRUG-DISCOVERYDuring her two-year M
Page 156 and 157:
chemically in various fashions. The
Page 158 and 159:
EARA-ESTThe European Association fo
Page 160 and 161:
‘Our programme is founded on the
Page 162 and 163:
GLADNETAccurate data about the qual
Page 164 and 165:
Working with industryIn addition to
Page 166 and 167:
MIGRANT CHILDRENImmigration has bec
Page 168 and 169:
Ireland possesses a category of mig
Page 170 and 171:
NANBIOPTICOne of the most exciting
Page 172 and 173:
Marie Curie support allowed me, amo
Page 174 and 175:
NANOMATCHDeveloping new and more ef
Page 176 and 177:
‘The ombudswoman is used quite fr
Page 178 and 179:
Europe is increasingly retaining it
Page 180 and 181:
well as the researcher’s scientif
Page 182 and 183:
ADAPTUNPREDICTThe Marie Curie progr
Page 184 and 185:
we understand the consequences bett
Page 186 and 187:
© stock.xchngCSS-OMICSStress is a
Page 188 and 189:
A key part of her research was to f
Page 190 and 191:
ELSAQUINTANA-NCSCSFor Spanish pharm
Page 192 and 193:
The cancer stem cell hypothesis pre
Page 194 and 195:
EXNER_BORISOVMany modern devices an
Page 196 and 197:
chips, for instance. ‘Of course,
Page 198 and 199:
HIVOXFORDIn late 2006, five Bulgari
Page 200 and 201:
that the accused medical personnel
Page 202 and 203:
© stock.xchngMARINE MAGNETISMIsn
Page 204 and 205:
aeolian dust. The second traces dus
Page 206 and 207:
MODPAPThe Modpap project has delive
Page 208 and 209: According to Dr Macpherson, Dr Pill
Page 210 and 211: NANOSWITCHIt calls to mind a scene
Page 212 and 213: ‘Throughout their journey, the na
Page 214 and 215: PIPKIGKOOne in every 700 babies bor
Page 216 and 217: focal adhesions of specifi c protei
Page 218 and 219: TARGETING PCD IN PDA Marie Curie gr
Page 220 and 221: the blood-brain barrier, the precur
Page 222 and 223: Science completely shapes the way w
Page 224 and 225: as labs and microscopes in order to
Page 226 and 227: BCRThe moon holds a strange fascina
Page 228 and 229: A new perspective on chronobiologyT
Page 230 and 231: © stock.xchngBIMORESolar energy is
Page 232 and 233: convert CO 2into a reduced carbon b
Page 234 and 235: CENS-CMAAs the Estonian coastline c
Page 236 and 237: The research visitors provided valu
Page 238 and 239: FLOODSVery few of us now question t
Page 240 and 241: The hunting ground for this preciou
Page 242 and 243: NANOMAG-LABThese days, the average
Page 244 and 245: What is more, Nanomag-Lab fostered
Page 246 and 247: NEPHILID SPIDERSSlovenian scientist
Page 248 and 249: One simple strategy involves the ma
Page 250 and 251: © stock.xchngWISEThe 32 countries
Page 252 and 253: and-tested methodology also include
Page 254 and 255: The quest for knowledge is a univer
Page 256 and 257: Global partnershipsBy opening up Eu
Page 260 and 261: nutrients and ensures blood supply
Page 262 and 263: BIOSEBOut in the middle of nowhere,
Page 264 and 265: free discussion evenings, and staff
Page 266 and 267: CAUSE KIDNEY DAMAGEA potentially de
Page 268 and 269: might contribute to the effect. ‘
Page 270 and 271: CAVEOLINSEvery breath becomes a whe
Page 272 and 273: ‘Our research revealed that the c
Page 274 and 275: EPISCONThe conservation and preserv
Page 276 and 277: able to follow whatever course my c
Page 278 and 279: © stock.xchngPARSEMUnder the Marie
Page 280 and 281: The research objectives of Parsem w
Page 282 and 283: NEURAL CIRCUITBlind mice can now se
Page 284 and 285: An international effortRecognising
Page 286 and 287: Being able to simultaneously build
Page 288 and 289: A number of initiatives can be impl
Page 290 and 291: EURYTHRONYoung researchers working
Page 292 and 293: Flexible work environmentThe resear
Page 294 and 295: INNATE IMMUNITYThe Innate Immunity
Page 296 and 297: more cytokines. Normally, this feed
Page 298 and 299: NLRS IN IMMUNITYMore than a million
Page 300 and 301: organisms and to shed light on the
Page 302 and 303: ZSN-PHD PROGRAMMEIt takes talent, t
Page 304 and 305: eview.’ The ZSN has also encourag
Page 306 and 307: The Marie Curie Actions are founded
Page 308:
All this is designed to achieve one
Page 311 and 312:
On soft groundWhen faced with groun
Page 313 and 314:
shared through annual workshops, in
Page 315 and 316:
And the Oscar goesto...When your ci
Page 317 and 318:
this, the software can take charact
Page 319 and 320:
Recreating the earlyuniverseParticl
Page 321 and 322:
Imagination equals discoveryDr Mast
Page 323 and 324:
Rock-solid researchinto shaky groun
Page 325 and 326:
existing ones with international sc
Page 327 and 328:
Wireless wisdomComputer networks ha
Page 329 and 330:
he recently received a Young Invest
Page 331 and 332:
It’s elementary:of quarks, lepton
Page 333 and 334:
A real career boostAdding into the
Page 335 and 336:
Spin,little electron, spinAt the ba
Page 337 and 338:
The armamentarium for new researchT
Page 339 and 340:
Putting an endto cluster bombtraged
Page 341 and 342:
elations, law and politics from the
Page 343 and 344:
Inspiring changein the wider resear
Page 345 and 346:
343
Page 347 and 348:
Good vibrationsThe Marie Curie Acti
Page 349 and 350:
to signifi cantly change the way Ph
Page 351 and 352:
MuTra: a labour of loveWhile the ge
Page 353:
sites in Berlin, Munich, Zürich, S
Page 356:
The Marie Curie Actions are widely
show all

Marie Curie Actions: Inspiring Researchers - Imdea

Create successful ePaper yourself

Delete template?

Save as template?