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Session XI: Cell death and cardiovascular diseases Poster XI, 7 Atrial appendages transcriptional profile in atrial fibrillation patients with structural heart diseases. Maria S. Kharlap, Angelica V.Timofeeva, Lyudmila E. Goryunova, George L. Khaspekov, Andrey V. Skamrov, Sergey L. Dzemeshkevich, Renat S. Akchurin, Sergey P.Golitsyn and Robert Sh. Beabealashvilli. Department of Clinical Electrophysiology/Laboratory of Genetic Engineering, Russian Cardiology Research and Development Complex, 3rd Cherepkovskaya str. 15a, 121552, Moscow, Russia. E-mail: kharlapmaria@yahoo.com During the last few years several investigations devoted to gene expression analysis in human atria in patients with atrial fibrillation (AF) have been performed. The subject of those studies was atrial tissue from the patients undergoing open heart surgery with sinus rhythm and with AF. Such kind of investigations were limited by the presence of structural changes associated with underlying heart disease in control atrial tissue samples. In this regard, it seemed to be reasonable to compare the atrial tissue samples from AF patients with those from subjects without structural heart diseases. For this purpose, we employed cDNA microarray technique. Tissue samples of right atrial appendages (RAA) were obtained from 12 AF patients undergoing open heart surgery with valve disease, myxoma and coronary artery disease. Control group included 11 autopsy RAA tissue samples from people with no signs of cardiovascular diseases died during the accidents. Gene expression was analyzed using Human cDNA Expression Arrays from Clontech (total 4704 genes). The results were verified by reverse transcription polymerase chain reaction. 15 genes were found to be down-regulated in AF patients independently of the type of the structural heart disease and ranged from 1.2 to 28 fold (p
Session XI: Cell death and cardiovascular diseases Poster XI, 8 Effects of selenium deficiency on the protein expression of tissues of the cardiovascular system A. Kyriakopoulos., A. Richter., C. Wolf., A. Plotnikov., I. Grbavac., D. Behne Hahn-Meitner-Institut, Dept. “Molecular Trace Element Research in the Life Sciences” Glienicker Str. 100, D-14109 Berlin, Germany. Organs of the cardiovascular system such as Heart and aorta contain a lot of mitochondria (powerhouse of the cell) in which the reactive oxygen species (ROS) are generated. ROS are damaging the cell. Antioxidantive system protects the cell against the aggressive ROS and inflammation. Some components of the antioxidative defence system are also metalloenzymes and selenoenzymes. In order to examine the expression of the heart and aorta proteins (part of them) in the homogenate of selenium deficient (Se-) and selenium control rats (Se+), 2 D electrophoresis was used by means of giga gels (30x35 cm). After the electrophoresis the protein-expression pattern of the (Se-)-gel and (Se+)-gel were compared. The evaluation of the protein difference was implemented by means of a computer program suitable for the analysis of protein separated by the two-dimensional electrophoresis. In this way more than 2000 proteins a gel (heart) were detected and more than 1900 protein spots were detected in the aorta fraction. Ten significant differences were found between the gel of (Se+) and (Se-)- heart of the rat and more than 15 significant differences between the gel of (Se+) and (Se-) of the aorta. By means of MALDI-MS/ESI-MS some of these proteins with the different expression level were determined until now. Of those three proteins were detected as the alpha myosin heavy chain (alpha-MHC), myosin light chain 1 and 2 (MLC 1 and 2) and the mitochondrial enzyme creatinin Kinase. First results suggest that selenium deficiency effects myocardial energy metabolism and contractile proteins. - 453 -
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- 1 - Luxembourg, January 25th to 2
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Table of content PREFACE ..........
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Preface In 1998, we organized the f
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Acknowledgments This meeting has be
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Group B (15h00 - 17h00) Session V.
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- 11 - Exhibition
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Visit our Expo (in alphabetical ord
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Thursday January 26th, 2006 (Early
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Thursday January 26th, 2006 (Evenin
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Regulation of inflammation and gluc
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Saturday January 28th, 2006 (Early
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Oral presentations (by alphabetical
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4: : Lottin S, Vercoutter-Edouart A
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the B-Raf/mitogen-activated/extrace
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Albertini MC, Accorsi A, Citterio B
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AP-1-dependent gene expression in s
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Jaks and cytokine receptors - an in
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The Role of Met-Gab1 Signalling in
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The mammalian tumor suppressor Scri
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SIGNAL TRANSDUCTION BY STRESS-ACTIV
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Title to be announced Caroline Dive
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Mechanisms of DNA methylation in ma
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Blocking the "4 Integrin-Paxillin I
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Regulation of NF-kB-dependent trans
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The immunomodulator AS101 induces g
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Signaling pathways leading to the a
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Boute, N., Jockers, R. and Issad, T
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Jespsen JS, Sorensen MD and Wengel
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8. Nishikawa, H., Kawai, K., Tanaka
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9) Proteome analysis of rat pancrea
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MicroRNA is an anti-apoptotic facto
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Resveratrol inhibits phorbol ester-
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Cross-talk between angiotensin II a
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Multiple role of histamine H 1 rece
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PI3K Targeting by the Beta-GBP Cyto
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D.P. Chopra, R.E. Menard, J. Janusz
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[2] Meijer, L., Flajolet, M. and Gr
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[4] Niemand, C., Nimmesgern, A., Ha
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Oncogenic signaling by mutant p53 M
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activity of the Peroxisome Prolifer
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Restauration of SHIP-1 activity in
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Hypoxia Signaling. Impact on Tumor
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5. Sokolov EI, Zykov KA, Pukhalsky
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HOW ANTITOXIC AND ANTICANCER AGENTS
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Listeria monocytogenes induced Rac1
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Epigenetic Regulation of Stem Cell
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Survey on in vitro cell death induc
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Distinct roles of IRF-3 and IRF-7 i
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Redox-Sensitive Transcription Facto
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Epigenic control of MHC2TA transcri
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Attenuation of MSK1-driven NF-kB ge
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Talking to chromatin: Silencers Sil
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Ubiquitin ligase Smurf1 controls os
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Workshop presentations (by alphabet
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Ambion MicroRNAs (miRNAs) are small
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Organizer: BIOBASE GmbH Date: Janua
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Reliable and efficient gene Knock-d
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Exploring ubiquitin signaling with
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Poster presentations Poster are cla
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Session I : protein domains Poster
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Notes Notes - 125 -
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Session II. Receptor signaling and
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Session II : Receptor signaling and
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Session III. Protein kinase cascade
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Session III : Protein kinase cascad
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Session IV. Protein kinase inhibito
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IV. Protein kinase inhibitors: insi
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IV. Protein kinase inhibitors: insi
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V. Phosphatases as key cell signali
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VI. Proteasome degradation pathways
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VI. Proteasome degradation pathways
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Session VII. Stem cell specific cel
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VIII. Inflammation specific signali
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Session IX. Novel compounds targeti
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Session X : Cell death in cancer -
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Session X : Cell death in cancer Po
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Session XIV : Transcriptional and t
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Session XV : Reactive oxygen specie
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Session XVI : Chemopreventive agent
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Session XVII : Cell signaling in he
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Dr. Nassera Aouali L-1526 Luxembour
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Dr. Giordano Bianchi Clinic of inte
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Mrs. Isabel Burghardt Laboratory of
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Pr. Czeslaw Cierniewski 92-215 Lodz
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Mr. Igotz Delgado Biochemistry 4894
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Dr. Mark Ginsberg Mail code 0726 92
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Dr. Jochen Hefl Division of Signal
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Mr. Jan Jepsen 2100 Copenhagen DNK
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Pr. Young Min Kim Division of Biolo
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Mr. Christoph Lahtz AG Tumorgenetik
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Mrs. Rasa Merzvinskyte Department o
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Mr. Gustav Nilsonne Department of L
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Dr. Gabriella Regis Tumor Immunolog
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