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Session XVII : Cell signaling in health and disease Poster XVII, 23 THE ANALGESIC AND ULCEROGENIC EFFECTS OF TRIBULUS TERRESTRIS EXTRACTS IN ANIMAL MODELS Mahmoud Reza Heidari, Jalal, Vafazadeh, Sayed Ahmad Hoseini , Mohammad Ghazi Khansari and Masood Yakhchali Dept. of Toxicology and Pharmacology, Faculty of Pharmacy, Neuroscience and Physiology Research Center, Kerman, Iran, Heidarimr@yahoo.com Tribulus terrestris has been used in traditional medicine as releiving reuhmatic pain and analgesic plant from long ago. Extraction of the fruits of plant was done by two different methods(suxheletion and perculation) with methanol 80%. The perculated extract with different doses 50, 100, 200, 400 and 800 mg/Kg were injected intaperitoneally to mice. The analgesic effects of the methanolic extract of this plant were evaluated by formalin and tailflick test in male albino mice. Ulcerogenicity test was done by Azuumi method using J Score. The dose of 100 mg/kg perculated extract had the highest analgesic effect in Formalin and Tail-flick test. The ulcerogenicity of plant extract is lower than the indomethacin. The extracts have had less pathologic effect in rat,s stomach. - 630 -
Session XVII : Cell signaling in health and disease Poster XVII, 24 Expression and protective role of heme oxygenase-1 in the delayed myocardial preconditioning Gabor Jancso, Barbara Cserepes, Balazs Borsiczky, Andrea Ferenc, Boglarka Racz, Janos Lantos, E Roth Department of Surgical Research and Techniques, Faculty of Medicine, University of Pécs, Pécs, Hungary ; e-mail: jancsogabor@hotmail.com Ischaemic preconditioning (PC) is an endogenous adaptation response of the myocardium to stress, whereby short ischaemic-reperfusion periods increase the myocardium’s tolerance to a longer ischaemic attack. Heme oxygenase (HO)-1, that degrades the pro-oxidant heme to carbon monoxide and to the antioxidant bilirubin, has been shown to protect cardiomyocytes against oxidative injury. We aimed to demonstrate the expression and protective effect of HO- 1 in the delayed PC. Neonatal rat cardiac myocytes were exposed to ischaemic PC (ischaemic medium for 20 min) and pharmacological (adenosine, norepinephrine, opioid) preconditioning (group 1). 24 hours later cells were subjected to a test ischaemia (TI) – culturing for 3 hours in ischaemic medium, following with a 2 h reperfusion in normal medium – and then lactate dehydrogenase (LDH), live/death ratio, and apoptosis were measured. In group 2. HO-1 enzymatic activity was competitively inhibited by administration of zinc protoporphyrin (ZnPPIX) after PC. In group 3. HO-1 synthesis was blocked with HO- 1 siRNA before PC. In group 4. HO-1 expression was induced by administration of cobalt protoporphyrin (CoPPIX). In the group 5. (control) we made only test ischaemia without preconditioning. Furthermore we demonstrated HO-1 expression in the various groups with immuno-staining. Our results showed a significant decrease of LDH release in PC groups vs. control group, that has been risen in ZnPPIX and HO-1 siRNA treated groups. Increased apoptosis and cell death were seen in PC groups which were treated with ZnPPIX and HO-1 siRNA. CoPPIX pretreatment resulted in decreased LDH level, apoptosis and cell death, which was comparable to PC groups. HO-1 immuno-staining showed an appreciable HO-1 expression in PC groups, which was abolished with HO-1 siRNA administration, but not in ZnPPIX group. Our results suggest that HO-1 expression increases in both ischaemic and pharmacological PC, and HO-1 has cellular protective effect against cell death and apoptosis in ischaemia-reperfusion induced oxidative injury. Supported by OTKA T-048851; OTKA F046593; OTKA F046504; OTKA T 038035. - 631 -
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- 1 - Luxembourg, January 25th to 2
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Table of content PREFACE ..........
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Preface In 1998, we organized the f
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Acknowledgments This meeting has be
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Group B (15h00 - 17h00) Session V.
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- 11 - Exhibition
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Visit our Expo (in alphabetical ord
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Thursday January 26th, 2006 (Early
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Thursday January 26th, 2006 (Evenin
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Regulation of inflammation and gluc
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Saturday January 28th, 2006 (Early
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Oral presentations (by alphabetical
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4: : Lottin S, Vercoutter-Edouart A
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the B-Raf/mitogen-activated/extrace
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Albertini MC, Accorsi A, Citterio B
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AP-1-dependent gene expression in s
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Jaks and cytokine receptors - an in
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The Role of Met-Gab1 Signalling in
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The mammalian tumor suppressor Scri
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SIGNAL TRANSDUCTION BY STRESS-ACTIV
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Title to be announced Caroline Dive
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Mechanisms of DNA methylation in ma
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Blocking the "4 Integrin-Paxillin I
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Regulation of NF-kB-dependent trans
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The immunomodulator AS101 induces g
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Signaling pathways leading to the a
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Boute, N., Jockers, R. and Issad, T
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Jespsen JS, Sorensen MD and Wengel
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8. Nishikawa, H., Kawai, K., Tanaka
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9) Proteome analysis of rat pancrea
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MicroRNA is an anti-apoptotic facto
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Resveratrol inhibits phorbol ester-
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Cross-talk between angiotensin II a
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Multiple role of histamine H 1 rece
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PI3K Targeting by the Beta-GBP Cyto
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D.P. Chopra, R.E. Menard, J. Janusz
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[2] Meijer, L., Flajolet, M. and Gr
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[4] Niemand, C., Nimmesgern, A., Ha
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Oncogenic signaling by mutant p53 M
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activity of the Peroxisome Prolifer
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Restauration of SHIP-1 activity in
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Hypoxia Signaling. Impact on Tumor
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5. Sokolov EI, Zykov KA, Pukhalsky
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HOW ANTITOXIC AND ANTICANCER AGENTS
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Listeria monocytogenes induced Rac1
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Epigenetic Regulation of Stem Cell
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Survey on in vitro cell death induc
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Distinct roles of IRF-3 and IRF-7 i
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Redox-Sensitive Transcription Facto
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Epigenic control of MHC2TA transcri
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Attenuation of MSK1-driven NF-kB ge
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Talking to chromatin: Silencers Sil
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Ubiquitin ligase Smurf1 controls os
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Workshop presentations (by alphabet
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Ambion MicroRNAs (miRNAs) are small
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Organizer: BIOBASE GmbH Date: Janua
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Reliable and efficient gene Knock-d
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Exploring ubiquitin signaling with
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Poster presentations Poster are cla
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Session I : protein domains Poster
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Session II. Receptor signaling and
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Session II : Receptor signaling and
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Session III. Protein kinase cascade
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Session III : Protein kinase cascad
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Session IV. Protein kinase inhibito
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IV. Protein kinase inhibitors: insi
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IV. Protein kinase inhibitors: insi
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V. Phosphatases as key cell signali
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VI. Proteasome degradation pathways
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VI. Proteasome degradation pathways
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Session VII. Stem cell specific cel
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VIII. Inflammation specific signali
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Session IX. Novel compounds targeti
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Session X : Cell death in cancer -
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Session X : Cell death in cancer Po
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Session XI : Cell death and cardiov
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Session XI: Cell death and cardiova
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Session XII : Cell death and neurod
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Session XIII : Cell signaling pathw
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Session XIV : Transcriptional and t
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Page 675 and 676: Dr. Nassera Aouali L-1526 Luxembour
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Pr. Czeslaw Cierniewski 92-215 Lodz
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Mr. Igotz Delgado Biochemistry 4894
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Dr. Mark Ginsberg Mail code 0726 92
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Dr. Jochen Hefl Division of Signal
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Mr. Jan Jepsen 2100 Copenhagen DNK
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Mrs. Rasa Merzvinskyte Department o
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Mr. Gustav Nilsonne Department of L
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Dr. Gabriella Regis Tumor Immunolog
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