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Crosstalk between NF-kB and AP-1 in Helicobacter pylori-mediated inflammation in human gastric epithelial cells Hyeyoung Kim Department of Pharmacology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Korea. Email: kim626@yumc.yonsei.ac.kr Previously we have shown that inflammatory enzymes such as cyclooxygenase-2 (COX-2) and inducible nitric oxide syntahse (iNOS) were expressed in H. pylori-infected gastric epithelial cells. The expression of COX-2 and iNOS may be regulated by NF-kB and AP-1. Present study aims to investigate whether H. pylori-induced expressions of COX-2 and iNOS are regulated by NF-kB and AP-1 in gastric epithelial AGS cells, and whether the transcriptional regulation of COX-2 or iNOS is inhibited by transfection of antisense oligodeoxynucleotide (AS ODN) for NF-kB subunit p50 or c-jun dominant negative mutant gene (TAM-67). As a result, H. pylori induced the expression of COX-2 and iNOS via activation of NF-kB and AP-1, which was inhibited in the cells transfected with either p50 AS ODN or TAM-67. The activated NF-kB complex was p65/p50 hetero- and p50/p50 homo- dimmers while the activated AP-1 complex was a c-jun/c-fos heterodimer in H. pyloriinfected AGS cells. In conclusion, NF-kB and AP-1 share H. pylori-mediated inflammation signaling by inducing COX-2 and iNOS expression in gastric epithelial cells. Either suppression of NF-kB or AP-1 may inhibit H. pylori-induced inflammation in gastric epithelial cells. Publication list (2002-2005) 1) NADPH oxidase and apoptosis in cerulein-stimulated pancreatic acinar cells. JH Yu, JW Lim, KH Kim, T Morio, H Kim. Free Rad Biol Med 39: 590-602, 2005 2) NADPH oxidase mediates interleukin-6 expression in cerulein-stimulated pancreatic acinar cells. JH Yu, JW Lim, H Kim, KH Kim, Int J Biochem Cell Biol 37:1458-1469, 2005 3) Cellular stress - related protein expression in Helicobacter pylori - infected gastric epithelial AGS cells. JW Lim, H Kim, JM Kim, JS Kim, HC Jung, KH Kim, Int J Biochem Cell Biol 36:1624-1634, 2004. 4) Oxidative stress - related proteome changes in Helicobacter pylori - infected human gastric mucosa. HY Baek, JW Lim, H Kim, JM Kim, JS Kim, HC Jung, KH Kim, Biochem J 379:291-299, 2004 5) Helicobacter pylori in a Korean isolate activates mitogen-activated protein kinases, AP-1, and NF-!B and induces chemokine expression in gastric epithelial AGS cells. JH Seo, JW Lim, H Kim, KH Kim, Lab Inv 84:49-62, 2004 6) The Ku antigen-recombination signal-binding protein J! complex binds to the nuclear factor-!B p50 promoter and acts as a positive regulator of p50 expression in human gastric cancer cells. JW Lim, H Kim, KH Kim, J Biol Chem 279(1):231-237, 2004 7) Role of oxygen free radicals in patients with acute pancreatitis. BK Park, JB Chung, JH Lee, JH Suh, SW Park, SY Song, H Kim, KH Kim, JK Kang, World J Gastroenterology 9(10):2266-2269, 2003 8) Oxidative stress induces nuclear loss of DNA repair proteins Ku70 and Ku80 and apoptosis in pancreatic acinar AR42J cells. JY Song, JW Lim, H Kim, T Morio, KH Kim.. J Biol Chem 278 (38):36676-36687, 2003 Oct. - 58 -
9) Proteome analysis of rat pancreatic acinar cells: Implication for cerulein - induced acute pancreatitis, JH Yu, SY Yun, H Kim, KH Kim, Proteomics 3(12):2446-2453, 2003 10) Mass spectrometry and tandem mass spectrometry analysis of rat pancreatic mitochondrial ATP synthase: upregulation in pancreatic acinar cells treated with cerulein, JH Yu, SY Yun, H Kim, KH Kim, Proteomics 3(12):2437-2445, 2003 11) The effect of p38 mitogen-activated protein kinase on mucin gene expression annd apoptosis in Helicobacter pylori-infected gastric epithelial cells, H Kim, JH Seo, KH Kim, Ann NY Acad Sci 1010:90-94, 2003 12) Role of NF-!B and DNA repair protein Ku on apoptosis in pancreatic acinar cells, JY Song, JW Lim, H Kim, KH Kim, Ann NY Acad Sci 1010:259-262, 2003 13) Calcium-dependent apoptotic gene expression in cerulein-treated AR42J cells, JH Yu, H Kim, KH Kim, Ann NY Acad Sci 1010:66-70, 2003 14) Signal transduction of cerulein-induced cytokine expression and apoptosis in pancreatic acinar cells, J Lee, J Seo, H Kim, JB Chung, KH Kim, Ann NY Acad Sci 1010:104-108, 2003 15) NF-kB and Bcl-2 in Helicobacter pylori-induced apoptosis in gastric epithelial cells, SH Chu, JW Lim, KH Kim, H Kim, Ann NY Acad Sci 1010:568-575, 2003 16) Diagnostic significance of antibodies to heat shock proteins, H Kim, Clinica Chemica Acta, 337:1-10, 2003 17) Cell adhesion - related gene expression by Helicobacter pylori in gastric epithelial AGS cells, JW Lim, H Kim, KH Kim, Int J Biochem Cell Biol, 35:1284-1296, 2003 18) Role of NF-kB and AP-1 on Helicobacter pylori-induced IL-8 expression in AGS cells. SH Chu, H Kim, JY Seo, JW Lim, N Mukaida, KH Kim, Dig Dis Sci 48(2): 257-265, 2003 19) Expression of Ku70 and Ku80 mediated by NF-kB and cyclooxygenase-2 are related to cell proliferation in human gastric cancer cells. JW Lim, H Kim, KH Kim, J Biol Chem 277(48):46093-46100, 2002 20) Transcriptional regulation by thiol compounds in Helicobacter pylori induced IL-8 production in human gastric epithelial cells. JY Seo, H Kim, KH Kim. Ann New York Acad Sci 973:541-545, 2002 21) Cyclooxygenase-2 expression by transcription factors in Helicobacter pylori-infected gastric epithelial cells: comparison between HP99 and NCTC 11637. JH Seo, H Kim, KH Kim. Ann New York Acad Sci 973:477-480, 2002 22) Suppression of cerulein-induced cytokine expression by antioxidants in pancreatic acinar cells. JH Yu, JW Lim, W Namkung, H Kim, KH Kim. Lab Inv 82(10):1359-1368, 2002 23) Effect of mannitol on Helicobacter pylori-induced cyclooxygenase-2 expression in gastric epithelial AGS cells. H Kim, JY Seo, KH Kim Pharmacology 66(4):182-189, 2002 Dec. 24) Oxidative stress-induced cytokine production in isolated rat pancreatic acinar cells; Effects of small molecule antioxidants. JY Seo, H Kim, JT Seo, KH Kim, Pharmacology 64(2):63-70, 2002 Feb. 25) Oxidant-sensitive transcription factor and cyclooxygenase-2 by Helicobacter pylori stimulation in human gastric cancer cell lines. H Kim, JW Lim, JY Seo, KH Kim, J Environmental Pathology, Toxicology and Oncology 21:121-129, 2002 - 59 -
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Table of content PREFACE ..........
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Preface In 1998, we organized the f
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Ambion MicroRNAs (miRNAs) are small
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Organizer: BIOBASE GmbH Date: Janua
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Reliable and efficient gene Knock-d
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Exploring ubiquitin signaling with
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Session I : protein domains Poster
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Session II. Receptor signaling and
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Session XIII : Cell signaling pathw
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Dr. Nassera Aouali L-1526 Luxembour
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