Visit our Expo - Redox and Inflammation signaling 2012

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Signaling of life and death in T cells Peter H. Krammer Tumorimmunology Program, German Cancer Research Center, Heidelberg, Germany): (no abstract provided) - 60 -
MicroRNA is an anti-apoptotic factor in human brain tumors Anna M. Krichevsky1, Jennifer A. Chan2, & Kenneth S. Kosik3 1 Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; 2 Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115 and 3 Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA MicroRNAs (miRNAs) are a recently discovered class of small 18-23 nucleotide non-coding RNA molecules that have been shown to regulate target gene expression in various organisms. By targeting the mRNA of protein-coding genes for either cleavage or repression of translation, miRNAs are thought to play critical roles in development, control of growth, proliferation, and cell lineage determination. Expression data and location in the human genome suggested the potential for this new class of regulatory RNAs to influence the processes of proliferation, differentiation and cell death in a human malignancy. Using our homemade oligonucleotide array designed to detect the majority of mammalian miRNAs identified thus far, we measured the expression levels of miRNAs during normal brain development, in the process of neurogenesis in vitro and in high-grade brain tumors, glioblastomas. Our study identified a specific miRNA, miR-21, that is markedly elevated in glioblastomas. We demonstrate that glioblastomas strongly overexpress this specific miRNA compared to low-grade brain tumors, non-neoplastic fetal and adult brain, neuronal and glial cultured cells, and stem cell-derived neural precursors, clearly linking this miRNA to malignancy. Sequence-specific knock-down of miR-21 with modified antisense oligonucleotides triggers activation of caspases and leads to increased apoptotic cell death of glioblastoma cells in culture, implying a role for this miRNA in gliomagenesis. Wholegenome expression profiling revealed that multiple proapoptotic genes as well as genes negatively regulating cell proliferation have been specifically induced after the knock-down of this miRNA. These findings suggest that the over-expressed miRNA may function as a micro-oncogene, presumably by blocking expression of key apoptosis-enabling genes. Moreover, our studies not only validate a functional role of miRNA in brain tumors, but also raise the possibility that miRNAs may serve as novel attractive targets in oncology. - 61 -
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- 1 - Luxembourg, January 25th to 2
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Table of content PREFACE ..........
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Preface In 1998, we organized the f
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Acknowledgments This meeting has be
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Page 19 and 20: Regulation of inflammation and gluc
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Page 23 and 24: Oral presentations (by alphabetical
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Page 35 and 36: The Role of Met-Gab1 Signalling in
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Page 43 and 44: Mechanisms of DNA methylation in ma
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Organizer: BIOBASE GmbH Date: Janua
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Reliable and efficient gene Knock-d
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Exploring ubiquitin signaling with
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Poster presentations Poster are cla
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Session I : protein domains Poster
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Session II. Receptor signaling and
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Session II : Receptor signaling and
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Session III. Protein kinase cascade
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Session III : Protein kinase cascad
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Session IV. Protein kinase inhibito
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IV. Protein kinase inhibitors: insi
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V. Phosphatases as key cell signali
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VI. Proteasome degradation pathways
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VI. Proteasome degradation pathways
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Session VII. Stem cell specific cel
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VIII. Inflammation specific signali
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Session XIII : Cell signaling pathw
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Dr. Nassera Aouali L-1526 Luxembour
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Dr. Giordano Bianchi Clinic of inte
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Mrs. Isabel Burghardt Laboratory of
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Pr. Czeslaw Cierniewski 92-215 Lodz
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Mr. Igotz Delgado Biochemistry 4894
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Dr. Mark Ginsberg Mail code 0726 92
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Dr. Jochen Hefl Division of Signal
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Mr. Jan Jepsen 2100 Copenhagen DNK
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Pr. Young Min Kim Division of Biolo
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Mr. Christoph Lahtz AG Tumorgenetik
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Mrs. Rasa Merzvinskyte Department o
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Pr. Moncef ZOUALI Centre Viggo Pete
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