Visit our Expo - Redox and Inflammation signaling 2012

Session XIV : Transcriptional and translational control Poster XIV, 32
Aromatase expression was not detected by immunohistochemistry in endometrial cancer
Yong-Tark Jeon, Jae Weon Kim, Noh-Hyun Park, Soon-Beom Kang, Hyo-Pyo Lee,
Yong-Sang Song
Department of Obstetrics and Gynecology, Cancer Research Institute, College of
Medicine, Seoul National University, Seoul, Korea, E-mail: yssong@snu.ac.kr
Several studies suggested that aromatase could play an important role in tumor progression
and prognosis in endometrial cancer because androstenedione is converted to estrogen by the
enzyme. For better understanding of the aromatase expression in endometrial cancer and its
relation to diverse clinicopathological parameters, we conducted this study. This study was
carried out with 141 endometrial cancer patients, all of whom had undergone operations in
our institution from 1993 to 2002. Paraffin-embedded tissue blocks were sectioned and
immunostained with monoclonal anti-aromatase antibody using human placental tissue as
positive control. Clinicopathological variables of all patients were also reviewed. Despite of
quite high aromatase expression in positive control, there was no endometrial cancer
specimen showing the enzyme expression. Our result, although need further investigation on
the cause of the difference from other studies, suggested that aromatase might not have
important role in endometrial cancer.
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