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Session XIV : Transcriptional and translational control Poster XIV, 43 DNA hypomethylation of CAGE Promoters in Squamous Cell Carcinoma of Uterine Cervix Taek Sang Lee a,b, Jae Weon Kima,b,c,*, Gyeong Hoon Kangb,d Noh Hyun Parka,b, Yong Sang Songa,b, Soon Beom Kanga,b, Hyo Pyo Leea,b aDepartment of Obstetrics and Gynecology, bCancer Research Institute, and cHuman Genome Research Institute, dDepartment of Pathology, College of Medicine, Seoul National University, Seoul, 110-744, Korea E-mail: kjwksh@snu.ac.kr This study was performed to determine whether promoter hypomethylation of CAGE is involved in cervical carcinogenesis. The surgical specimens from 40 cervical squamous cell carcinoma patients who treated at Seoul National University Hospital and from 48 healthy controls were used with informed consent. By methylation specific PCR (MSP) using unmethylation specific primer, the promoter hypomethylation status of CAGE was investigated. We found that hypomethylation of CAGE promoter was present at frequencies of nearly one hundred percent in cervical squamous cell carcinomas (38/40, 95%), but less than 4% in controls (p
Session XIV : Transcriptional and translational control Poster XIV, 44 Identification in rat of a yeast She3 homolog as interaction partner of AATF Peter Leister, Sven Burgdorf, Andrea Felten, Lutz Uhlmann, and Karl Heinz Scheidtmann Institute of Genetics, University of Bonn Roemerstr. 164, D-53117 Bonn peterleister@uni-bonn.de AATF, or Che-1, is a coactivator of several transcription factors including steroid hormone receptors, E2F, and SP1. In search of novel interaction partners of AATF we identified a so far unknown protein from rat with high degree of homology to She3p from budding yeast. She3p is an adapter protein for myosinV type motor protein Myo4p and is involved in selective transport of mRNA and ER vesicles. The novel protein was termed SHIA for She3 Homolog Interacting with AATF. A single transcript of SHIA mRNA of 1050 bp was highly expressed in brain, heart, spleen, liver, testis and kidney and to a lower extent in lung, whereas it was undetectable in skeletal muscle. However, sequence alignments with database sequences revealed that human, mouse and rat orthologs exist in two or three isoforms generated by alternative splicing or alternative usage of start codons, giving rize to polypeptides of 142 and 99 residues, respectively. Strikingly, besides some variations at their N-termini SHIA proteins are extremely conserved. A core sequence between residues 20 and 140 is strictly conserved within all vertebrates represented in the database, and certain sequence motifs are found even in insects and C. elegans and yeast. This high degree of conservation suggests that SHIA plays an essential role in all eukaryotes. The rat SHIA clone isolated appears to contain an extra exon (termed exon 2b) resulting in a protein of 168 amino acids with MW of 20 kDa. SHIA contains a She3p homology region at its N-terminus and a leucine zipper at its C-terminus, which mediates interaction with AATF. When expressed as GFP fusion protein, GFP-SHIA was localized in the cytoplasm, preferentially nuclear near structures and the actin cytoskeleton. A small fraction of GFP- SHIA was also observed within the nucleus. Overexpression of SHIA resulted in disturbed actin fibers, and coexpression of SHIA and AATF resulted in partial relocalisation of AATF from the nucleus to the cytoplasm. Interestingly, SHIA enhanced reporter gene activty in androgen receptor based transactivation assays, thus, SHIA behaved like a transcriptional coactivator. - 547 -
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- 1 - Luxembourg, January 25th to 2
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Table of content PREFACE ..........
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Preface In 1998, we organized the f
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Acknowledgments This meeting has be
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Group B (15h00 - 17h00) Session V.
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- 11 - Exhibition
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Visit our Expo (in alphabetical ord
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Thursday January 26th, 2006 (Early
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Thursday January 26th, 2006 (Evenin
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Regulation of inflammation and gluc
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Saturday January 28th, 2006 (Early
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Oral presentations (by alphabetical
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4: : Lottin S, Vercoutter-Edouart A
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the B-Raf/mitogen-activated/extrace
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Albertini MC, Accorsi A, Citterio B
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AP-1-dependent gene expression in s
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Jaks and cytokine receptors - an in
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The Role of Met-Gab1 Signalling in
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The mammalian tumor suppressor Scri
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SIGNAL TRANSDUCTION BY STRESS-ACTIV
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Title to be announced Caroline Dive
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Mechanisms of DNA methylation in ma
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Blocking the "4 Integrin-Paxillin I
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Regulation of NF-kB-dependent trans
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The immunomodulator AS101 induces g
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Signaling pathways leading to the a
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Boute, N., Jockers, R. and Issad, T
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Jespsen JS, Sorensen MD and Wengel
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8. Nishikawa, H., Kawai, K., Tanaka
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9) Proteome analysis of rat pancrea
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MicroRNA is an anti-apoptotic facto
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Resveratrol inhibits phorbol ester-
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Cross-talk between angiotensin II a
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Multiple role of histamine H 1 rece
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PI3K Targeting by the Beta-GBP Cyto
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D.P. Chopra, R.E. Menard, J. Janusz
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[2] Meijer, L., Flajolet, M. and Gr
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[4] Niemand, C., Nimmesgern, A., Ha
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Oncogenic signaling by mutant p53 M
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activity of the Peroxisome Prolifer
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Restauration of SHIP-1 activity in
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Hypoxia Signaling. Impact on Tumor
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5. Sokolov EI, Zykov KA, Pukhalsky
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HOW ANTITOXIC AND ANTICANCER AGENTS
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Listeria monocytogenes induced Rac1
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Epigenetic Regulation of Stem Cell
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Survey on in vitro cell death induc
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Distinct roles of IRF-3 and IRF-7 i
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Redox-Sensitive Transcription Facto
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Epigenic control of MHC2TA transcri
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Attenuation of MSK1-driven NF-kB ge
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Talking to chromatin: Silencers Sil
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Ubiquitin ligase Smurf1 controls os
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Workshop presentations (by alphabet
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Ambion MicroRNAs (miRNAs) are small
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Organizer: BIOBASE GmbH Date: Janua
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Reliable and efficient gene Knock-d
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Exploring ubiquitin signaling with
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Poster presentations Poster are cla
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Session I : protein domains Poster
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Session II. Receptor signaling and
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Session II : Receptor signaling and
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Session III. Protein kinase cascade
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Session III : Protein kinase cascad
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Session IV. Protein kinase inhibito
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IV. Protein kinase inhibitors: insi
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IV. Protein kinase inhibitors: insi
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V. Phosphatases as key cell signali
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VI. Proteasome degradation pathways
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VI. Proteasome degradation pathways
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Session VII. Stem cell specific cel
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VIII. Inflammation specific signali
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Session IX. Novel compounds targeti
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Session X : Cell death in cancer -
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Session X : Cell death in cancer Po
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Session XI : Cell death and cardiov
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Session XI: Cell death and cardiova
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Session XII : Cell death and neurod
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Session XIII : Cell signaling pathw
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Session XVI : Chemopreventive agent
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Session XVII : Cell signaling in he
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Dr. Nassera Aouali L-1526 Luxembour
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Dr. Giordano Bianchi Clinic of inte
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Mrs. Isabel Burghardt Laboratory of
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Pr. Czeslaw Cierniewski 92-215 Lodz
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Mr. Igotz Delgado Biochemistry 4894
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Dr. Mark Ginsberg Mail code 0726 92
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Dr. Jochen Hefl Division of Signal
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Mr. Jan Jepsen 2100 Copenhagen DNK
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Pr. Young Min Kim Division of Biolo
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Mr. Christoph Lahtz AG Tumorgenetik
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Mrs. Rasa Merzvinskyte Department o
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Mr. Gustav Nilsonne Department of L
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Mrs. Christel Péqueux Tumour and D
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Dr. Gabriella Regis Tumor Immunolog
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