109 Xaus J, Comalada M, Barrachina M, Herrero C, Gonalons E, Soler C, Lloberas J, Celada A. J Immunol 2000; 165: 6364±6371. 110 Yazawa T, Kamma H, Fujiwara M, Matsui M, Horiguchi H, Satoh H, Fujimoto M,Yokoyama K, Ogata T. J Pathol 1999; 187: 191±199. 111 Lu Y, Boss JM, Hu SX, Xu HJ, Blanck G. J Immunol 1996; 156: 2495± 2502. 112 Sartoris S,Valle MT, De Lerma Barbaro A, Tosi G, Cestari T, D'AgostinoA, Megiovanni AM, Manca F, Accolla RS. J Immunol 1998; 161: 814±820. 113 Kielar ML, Sicher SC, Penfield JG, Jeyarajah DR, Lu CY. Inflammation 2000; 24: 431±445. 114 van den Elsen P, Peijnenburg A, van Eggermond MCJA, Gobin SJP. Immunol Today 1998; 19: 308±312. 115 Walter W, Lingnau K, Schmitt E, Loos M, Maeurer MJ. Br J <strong>Cancer</strong> 2000; 83: 1192±1201. 116 Mach B, Steimle V, Martinez-Soria E, Reith W. Annu Rev Immunol 1996; 14: 301±331. 117 Bach EA, Aguet M, Schreiber RD. Annu Rev Immunol 1997; 15: 749±797. 118 Hung WC, Chuang LY. Br J <strong>Cancer</strong> 1999; 80: 705±710. 119 Dighe AS, Richards E, Old LJ, Schreiber RD. Immunity 1994; 1: 447± 456. 120 Kaplan DH, Shankaran V, Dighe AS, Stockert E, Aguet M, Old LJ, Schreiber RD. Proc Natl Acad Sci USA 1998; 95: 7556±7561. 121 Blanar M, Baldwin ASJ, Flavell RA, Sharpe PA. EMBO J 1989; 8: 1139± 1144. 122 Wright KL White LC, Kelly A, Beck S, Trowsdale JJ, Ting JPY. J Exp Med 1995; 181: 1459±1571. 123 Xi H, Eason DD, Ghosh D, Dovhey S, Wright KL, Blanck G. Oncogene 1999; 18: 5889±5903. 124 Muhlethaler-Mottet A, Otten LA, Steimle V, Mach B. EMBO J 1997; 16: 2851±2860. 125 Gil P, Bohn E, O'Guin AK, Ramana CV, Levine B, Stark GR,Virgin HW, References Schreiber RD. Proc Natl Acad Sci USA 2001; 98: 6680±6685. 126 Nozawa H, Oda E, Ueda S, Tamura G, Maesawa C, MutoT, Taniguchi T, Tanaka N. Int J <strong>Cancer</strong> 1998; 77: 522± 527. 127 Willman CL, Sever CE, Pallvicini MG, Harada H, Tanaka N, Slovak ML, Yamamoto H, Harada K, Meeker TC, List AF Taniguchi T. Science 1995; 259: 968±971. 128 Xi H, Blanck G. Int J <strong>Cancer</strong> 2001; 87: 803±808. 129 Lowney JK, Boucher LD, Swanson PE, Doherty GM. Ann Surg Oncol 1999; 6: 604±608. 130 Svane IM, Engel AM, Nielsen M, Werdelin O. Sc<strong>and</strong> J Immunol 1997; 46: 379±387. 131 Abril E, Real LM, SerranoA, Jiminez P, Garcia A, Canton J, Trigo I, GarridoF, Ruiz-CabelloF. <strong>Cancer</strong> Immunol Immunother 1998; 47: 113± 120. 132 Paul P, Rouas-Freiss N, Khalil-Daher I, Moreau P, Riteau B, Le Gal FA, Avril MF, Dausset J, Guillet JG, Carosella ED. Proc Natl Acad Sci USA 1998; 95: 4510±4515. 133 Paul P, Cabestre FA, Le Gal FA, Khalil-Daher I, Le Danff C, Schmid M, Mercier S, Avril MF, Dausset J, Guillet JG, Carosella ED. <strong>Cancer</strong> Res 1999; 59: 1954±1960. 134 Rouas-Freiss N, Khalil-Daher I, Riteau B, Menier C, Paul P, Dausset J, Carosella ED. Semin <strong>Cancer</strong> Biol 1999; 9: 3±12. 135 Fukushima Y, Oshika Y, Nakamura M, Tokunaga T, Hatanaka H, Abe Y,Yamazaki H, Kijima H, Ueyama Y, Tamaoki N. Int J Mol Med 1998; 2: 349± 351. 136 Real LM, Cabrera T, Collado A, Jimenez P, Garcia A, Ruiz-CabelloF, GarridoF. Int J <strong>Cancer</strong> 1999; 81: 512±518. 137 Davies B, Hil<strong>by</strong> S, Gardner L, Loke YW, King A. Am J Reprod Immunol 2001; 45: 103±107. 138 Urosevic M, Kurrer MO, Kamarashev J, Mueller B,Weder W, Burg G, Stabel RA, Dummer R, Trojan A. Am J Pathol 2001; 159: 817±824. 93
94 5 Major Histocompatibility Complex Modulation <strong>and</strong> Loss 139 FrumentoG, FranchelloS, Palmisano GL, Nicotra MR, Giacomini P, Loke YW, Geragthy D, Maio M, ManzoC, Natali PG, Ferrara GB. Tissue Antigens 2000; 56: 30±37. 140 Polakova K, Russ G. Neoplasma 2000; 47: 342±348. 141 Wagner SN, Rebmann V,Willers CP, Grosse-Wilde H, Goos M. Lancet 2000; 356: 220±221. 142 Trowsdale J, Ragoussis J, Campbell RD. Immunol Today 1991; 12: 443±446. 143 Herberg JA, Sgouros J, Jones T, Copeman J, Humphray SJ, Sheer D, Cresswell P, Beck S, Trowsdale J. Eur J Immunol 1998; 28: 459±467. 144 Benitez R, Godelaine D, LÕpez-Nevot MA, Brasseur F, Jim nez P, March<strong>and</strong> M, Oliva MR, van Baren N, Cabrera T, Andry G, L<strong>and</strong>ry C, Ruiz- Cabello F, Boon T, Garrido F. Tissue Antigens 1998; 52: 520±529. 145 Bicknell DC, Rowan A, Bodmer WF. Proc Natl Acad Sci USA 1994; 91: 4751± 4755. 146 Browning M, Petronzelli F, Bicknell D, Krausa P, Rowan A, Tonks S, Murray N, Bodmer J, Bodmer W. Tissue Antigens 1996; 47: 364±371. 147 Rosa F, Berissi H,Weinssenbach J, Maroteaux L, Fellous M, Revel M. EMBO J 1983; 2: 239±243. 148 Chen HL, Gabrilovich D,Virmani A Ratnani I, Girgis KR, Nadaf- Rahrov S, Fern—ndez-Viµa M, Carbone P. Int J <strong>Cancer</strong>1996; 67: 756±763. 149 Real LM, Jim nez P, CantÕn J, Kirkin A, GarcÌa A, Abril E, Zeuthen J, Ruiz-CabelloF, GarridoF. Int J <strong>Cancer</strong> 1998; 75: 317±323. 150 M ndez R, SerranoA, Jåger E, MalenoI, Ruiz-CabelloF, Knuth A, GarridoF. Tissue Antigens, 2001; 57: 508±519. 151 S<strong>and</strong>a MG, RestifoNP,Walsh JC, Kawakami Y, Nelson WG, Pardoll DM, Simons JW. J Natl <strong>Cancer</strong> Inst 1995; 87: 280±285. 152 RestifoNP, Esquivel F, Kawakami Y, Yewdell JW, Mul JJ, Rosenberg SA, Bennink JR. J Exp Med 1993; 177: 265±272. 153 Browning MJ, Krausa P, Rowan A, Hill AB, Bicknell DC, Bodmer JG, Bodmer WF. J Immunother 1993; 14: 163±168. 154 Hurks HM, Metzelaar-Blok JA, Mulder A, Claas FH, Jager MJ. Int J <strong>Cancer</strong> 2000; 85: 697±702. 155 Koopman LA, Mulder A, Corver WE, Anholts JD, Giphart MJ, Claas FH, Fleuren GJ. Tissue Antigens 1998; 51: 623±636. 156 Koopman LA, van der Silk AR, Giphart MJ, Fleuren GJ. J Natl <strong>Cancer</strong> Inst 1999; 91: 1669±1677. 157 Brady CS, Bartholomew JS, Burt DJ, Duggan-Keen Glenville S,Telford N, Little AM, Davidson JA, Jim nez P, Ruiz-CabelloF, GarridoF, Stern PL. Tissue Antigens 2000; 55: 401±411. 158 Wang Z, Marincola FM, Rivoltini L, Parmiani G, Ferrone S. J Exp Med 1999; 190: 205±215. 159 Gattoni-Celli S, Kirsch K, Timpane R, Isselbacher KJ. <strong>Cancer</strong> Res 1992; 52: 1201±1204. 160 Seliger B, Hohne A, Jung D, Kallfelz M, Knuth A, Jaeger E, Bernhard H, Momburg F, Tampe R, Huber C. Exp Hematol 1997; 25: 608± 614. 161 Schrier PI,Versteeg R, Peltenburg LT, Plomp AC, van't Veer LJ, Kruse- Wolters KM. Semin <strong>Cancer</strong> Biol 1991; 2: 73±83. 162 Seliger B, Ritz U, Abele R, Bock M, Tampe R, Sutter G, Drexler I, Huber C, Ferrpme S. <strong>Cancer</strong> Res 2001; 24: 8647±50. 163 Qin Z, Blankenstein T. Immunity 2000; 6: 677±86.
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Cancer Immune Therapie: Current and
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Editors: Dr. Gernot Stuhler Univers
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VI Preface Recent years have seen a
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VIII Contents 2.5.3 Antigens Encode
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X Contents 6.4.2 Natural Killer (NK
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XII Contents 9.6 Loading DC with An
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XIV Contents 14.2.2.1 Cancer-specif
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List of Contributors Richard Bucala
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Color Plates Fig. 5.2 The MHC class
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Fig. 5.5 Different immune effector
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Fig. 5.17 Possible pathway for the
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Fig. 6.2 T lymphocytes in the tumor
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Index a acidic and basic fibroblast
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±, see also tumors cationic lipids
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e EBV see Epstein-Barr virus EDR se
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immature Mo-DCs 184 immune cells ±
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MHC class I antigen-processing mach
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TICD see tumor-induced cell death T
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Part 1 Tumor Antigenicity Cancer Im
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4 1 Search for Universal Tumor-Asso
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6 1 Search for Universal Tumor-Asso
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26 2 Serological Determinants On Tu
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28 2 Serological Determinants On Tu
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30 Cancer Immune Therapie: Current
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32 3 Processing and Presentation of
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34 3 Processing and Presentation of
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36 3 Processing and Presentation of
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38 3 Processing and Presentation of
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148 7 Immunosuppresive Factors in C
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150 7 Immunosuppresive Factors in C
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152 7 Immunosuppresive Factors in C
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154 7 Immunosuppresive Factors in C
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156 8 Interleukin-10 in Cancer Immu
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158 8 Interleukin-10 in Cancer Immu
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160 8 Interleukin-10 in Cancer Immu
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162 8 Interleukin-10 in Cancer Immu
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164 8 Interleukin-10 in Cancer Immu
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166 8 Interleukin-10 in Cancer Immu
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168 8 Interleukin-10 in Cancer Immu
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170 8 Interleukin-10 in Cancer Immu
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172 8 Interleukin-10 in Cancer Immu
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174 8 Interleukin-10 in Cancer Immu
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180 9 Dendritic Cells and Cancer: P
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184 9 Dendritic Cells and Cancer: P
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198 9 Dendritic Cells and Cancer: P
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200 9 Dendritic Cells and Cancer: P
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204 Cancer Immune Therapie: Current
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206 10 The Immune System in Cancer:
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208 10 The Immune System in Cancer:
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210 10 The Immune System in Cancer:
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212 10 The Immune System in Cancer:
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216 10 The Immune System in Cancer:
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218 10 The Immune System in Cancer:
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220 10 The Immune System in Cancer:
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222 10 The Immune System in Cancer:
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224 10 The Immune System in Cancer:
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226 10 The Immune System in Cancer:
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228 10 The Immune System in Cancer:
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230 Cancer Immune Therapie: Current
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232 11 Hybrid Cell Vaccination for
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234 11 Hybrid Cell Vaccination for
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236 11 Hybrid Cell Vaccination for
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238 11 Hybrid Cell Vaccination for
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240 11 Hybrid Cell Vaccination for
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242 11 Hybrid Cell Vaccination for
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244 11 Hybrid Cell Vaccination for
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246 11 Hybrid Cell Vaccination for
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248 11 Hybrid Cell Vaccination for
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250 11 Hybrid Cell Vaccination for
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252 11 Hybrid Cell Vaccination for
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254 12 Principles and Strategies Em
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256 12 Principles and Strategies Em
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258 12 Principles and Strategies Em
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260 12 Principles and Strategies Em
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262 12 Principles and Strategies Em
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264 12 Principles and Strategies Em
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266 12 Principles and Strategies Em
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268 Cancer Immune Therapie: Current
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270 13 Applications of CpG Motifs f
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272 13 Applications of CpG Motifs f
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274 13 Applications of CpG Motifs f
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276 13 Applications of CpG Motifs f
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278 13 Applications of CpG Motifs f
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280 13 Applications of CpG Motifs f
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282 13 Applications of CpG Motifs f
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284 13 Applications of CpG Motifs f
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286 13 Applications of CpG Motifs f
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288 14 The T-Body Approach: Towards
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290 14 The T-Body Approach: Towards
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292 14 The T-Body Approach: Towards
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294 14 The T-Body Approach: Towards
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296 14 The T-Body Approach: Towards
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298 14 The T-Body Approach: Towards
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300 15 Bone Marrow Transplantation
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302 15 Bone Marrow Transplantation
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304 15 Bone Marrow Transplantation
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306 15 Bone Marrow Transplantation
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308 15 Bone Marrow Transplantation
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310 15 Bone Marrow Transplantation
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312 16 Immunocytokines: Versatile M
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348 17 Immunotoxins and Recombinant
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350 17 Immunotoxins and Recombinant
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352 17 Immunotoxins and Recombinant
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354 17 Immunotoxins and Recombinant
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356 17 Immunotoxins and Recombinant
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358 17 Immunotoxins and Recombinant
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360 17 Immunotoxins and Recombinant
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362 17 Immunotoxins and Recombinant
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364 17 Immunotoxins and Recombinant
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366 17 Immunotoxins and Recombinant
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368 17 Immunotoxins and Recombinant
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370 17 Immunotoxins and Recombinant
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372 17 Immunotoxins and Recombinant
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374 17 Immunotoxins and Recombinant
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376 17 Immunotoxins and Recombinant
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378 17 Immunotoxins and Recombinant
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380 Cancer Immune Therapie: Current
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382 Glossary tion to the variable d
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384 Glossary suppressor gene produc
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386 Glossary press the proper recep
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388 Glossary gp96 See Chaperone. Gr
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390 Glossary cytes and addressing l
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392 Glossary T bodies are being tes