Saffran, D. C. <strong>and</strong> Afar, D. E. Proc Natl Acad Sci USA 1999; 96: 14523±8. 37 Su, Z. Z., Lin, J., Shen, R., Fisher, P. E., Goldstein, N. I. <strong>and</strong> Fisher, P. B. Proc Natl Acad Sci USA 1996; 93: 7252± 7. 38 Lyne, J. C., Melhem, M. F., Finley, G. G., Wen, D., Liu, N., Deng, D. H. <strong>and</strong> Salup, R., <strong>Cancer</strong> J Sci Am 1997; 3: 21±30. 39 Signoretti, S., Montironi, R., Manola, J., Altimari, A.,Tam, C., Bubley, G., Balk, S.,Thomas, G., Kaplan, I., Hlatky, L., Hahnfeldt, P., Kantoff, P. <strong>and</strong> Loda, M. J Natl <strong>Cancer</strong> Inst 2000; 92: 1918±25. 40 Mitsuyasu, R. T., Anton, P. A., Deeks, S. G., Scadden, D. T., Connick, E., Downs, M. T., Bakker, A., Roberts, M. R., June, C. H., Jalali, S., Lin, A. A., Pennathur-Das, R. <strong>and</strong> Hege, K. M. Blood 2000; 96: 785±93. 41 Warren, R., Fisher, G. <strong>and</strong> Bergal<strong>and</strong>, E. Abstracts of the 7th Int Conf on Gene <strong>Therapy</strong> of <strong>Cancer</strong> 1998. <strong>Cancer</strong> Gene <strong>Therapy</strong> 1998; 5: Suppl. 6, 1±35. 42 Junghans, R., Safa, M. <strong>and</strong> Huberman, M. Proc Am Ass <strong>Cancer</strong> Res 2000; 41: 543. 43 Kershaw, M. H.,Westwood, J. A., Zhu, Z.,Witte, L., Libutti, S. K. <strong>and</strong> Hwu, P. Hum Gene Ther 2000; 11: 2445±52. 44 Darcy, P. K., Kershaw, M. H., Trapani, J. A. <strong>and</strong> Smyth, M. J. Eur J Immunol 1998; 28: 1663±72. 45 Hombach, A., Koch, D., Sircar, R., Heuser, C., Diehl,V., Kruis,W., Pohl, C. <strong>and</strong> Abken, H. Gene Ther 1999; 6: 300±4. 46 Nolan, K.,Yun, C., Akamatsu,Y., Murphy, J., Leung, S., Beecham, E. <strong>and</strong> Junghans, R. Clin <strong>Cancer</strong> Res 1999; 5: 3928±3941. 47 Hombach, A., Schneider, C., Sent, D., Koch, D.,Willemsen, R. A., Diehl,V., Kruis,W., Bolhuis, R. L., Pohl, C. <strong>and</strong> Abken, H. Int J <strong>Cancer</strong> 2000; 88: 115± 20. 48 Beecham, E. J., Ma, Q., Ripley, R. <strong>and</strong> Junghans, R. P. J Immunother 2000; 23: 631±42. 49 Kuroki, M., Arakawa, F., Khare, P. D., Liao, S., Matsumoto, H., Abe, H. <strong>and</strong> References Imakiire, T. Anticancer Res 2000; 20: 4067±71. 50 Haynes, N. M., Snook, M. B., Trapani, J. A., Cerruti, L., Jane, S. M., Smyth, M. J. <strong>and</strong> Darcy, P. K. J Immunol 2001; 166: 182±7. 51 Jensen, M., Tan, G., Forman, S., Wu, A. M. <strong>and</strong> Raubitschek, A. Biol Blood Marrow Transplant 1998; 4: 75± 83. 52 Hombach, A., Heuser, C., Sircar, R., Tillmann, T., Diehl,V., Pohl, C. <strong>and</strong> Abken, H. <strong>Cancer</strong> Res 1998; 58: 1116±9. 53 Hombach, A., Heuser, C., Sircar, R., Tillmann, T., Diehl,V., Pohl, C. <strong>and</strong> Abken, H. J Immunother 1999; 22: 473±80. 54 Hekele, A., Dall, P., Moritz, D., Wels,W., Groner, B., Herrlich, P. <strong>and</strong> Ponta, H. Int J <strong>Cancer</strong> 1996; 68: 232±8. 55 Dall, P., Hekele, A., Beckmann, M. W., Bender, H. G., Herrlich, P. <strong>and</strong> Ponta, H. Gynecol Oncol 1997; 66: 209± 16. 56 Daly, T., Royal, R. E., Kershaw, M. H., Treisman, J.,Wang, G., Li,W., Herlyn, D., Eshhar, Z. <strong>and</strong> Hwu, P. <strong>Cancer</strong> Gene Ther 2000; 7: 284±91. 57 Ren-Heidenreich, L., Hayman, G. T. <strong>and</strong> Trevor, K. T. Hum Gene Ther 2000; 11: 9±19. 58 Hwu, P., Shafer, G., Treisman, J., Schindler, D., Gross, G., Cowherd, R., Rosenberg, S. <strong>and</strong> Eshhar, Z. J Exp Med 1993; 178: 361±366. 59 Parker, L. L., Do, M. T.,Westwood, J. A., Wunderlich, J. R., Dudley, M. E., Rosenberg, S. A. <strong>and</strong> Hwu, P. Hum Gene Ther 2000; 11: 2377±87. 60 Weijtens, M. E.,Willemsen, R. A., Valerio, D., Stam, K. <strong>and</strong> Bolhuis, R. L. J Immunol 1996; 157: 836±43. 61 Weijtens, M. E., Hart, E. H. <strong>and</strong> Bolhuis, R. L. Gene Ther 2000; 7: 35±42. 62 Weijtens, M. E.,Willemsen, R. A., Hart, E. H. <strong>and</strong> Bolhuis, R. L. Gene Ther 1998; 5: 1195±203. 63 Yun, C. O., Nolan, K. F., Beecham, E. J., Reisfeld, R. A. <strong>and</strong> Junghans, R. P., Neoplasia 2000; 2: 449±59. 64 Reinhold, U., Liu, L., Ludtke-H<strong>and</strong>jery, H. C., Heuser, C., Hombach, A., Wang, X., Tilgen,W., Ferrone, S. <strong>and</strong> 297
298 14 The T-Body Approach: Towards <strong>Cancer</strong> Immuno-Gene <strong>Therapy</strong> Abken, H. J Invest Dermatol 1999; 112: 744±50. 65 Mezzanzanica, D., Canevari, S., Mazzoni, A., Figini, M., Colnaghi, M. I., Waks,T., Schindler, D. G. <strong>and</strong> Eshhar, Z. <strong>Cancer</strong> Gene Ther 1998; 5: 401±7. 66 Hombach, A., Heuser, C., Sircar, R., Tillmann, T., Diehl,V., Kruis,W., Pohl, C. <strong>and</strong> Abken, H. Gastroenterology 1997; 113: 1163±70. 67 Patel, S. D., Ge,Y., Moskalenko, M. <strong>and</strong> McArthur, J. G. J Immunother 2000; 23: 661±8.
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Cancer Immune Therapie: Current and
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Editors: Dr. Gernot Stuhler Univers
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VI Preface Recent years have seen a
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VIII Contents 2.5.3 Antigens Encode
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X Contents 6.4.2 Natural Killer (NK
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XII Contents 9.6 Loading DC with An
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XIV Contents 14.2.2.1 Cancer-specif
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List of Contributors Richard Bucala
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Color Plates Fig. 5.2 The MHC class
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Fig. 5.5 Different immune effector
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Fig. 5.17 Possible pathway for the
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Fig. 6.2 T lymphocytes in the tumor
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Index a acidic and basic fibroblast
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±, see also tumors cationic lipids
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e EBV see Epstein-Barr virus EDR se
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immature Mo-DCs 184 immune cells ±
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MHC class I antigen-processing mach
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TICD see tumor-induced cell death T
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Part 1 Tumor Antigenicity Cancer Im
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4 1 Search for Universal Tumor-Asso
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32 3 Processing and Presentation of
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38 3 Processing and Presentation of
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40 Cancer Immune Therapie: Current
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42 4 T Cells In Tumor Immunity cult
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44 4 T Cells In Tumor Immunity cell
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46 4 T Cells In Tumor Immunity to T
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48 4 T Cells In Tumor Immunity Alth
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50 4 T Cells In Tumor Immunity Tab.
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52 4 T Cells In Tumor Immunity rest
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54 4 T Cells In Tumor Immunity 53 T
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60 5 Major Histocompatibility Compl
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96 6 Immune Cells in the Tumor Micr
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100 6 Immune Cells in the Tumor Mic
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102 6 Immune Cells in the Tumor Mic
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104 6 Immune Cells in the Tumor Mic
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106 6 Immune Cells in the Tumor Mic
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108 6 Immune Cells in the Tumor Mic
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112 6 Immune Cells in the Tumor Mic
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114 6 Immune Cells in the Tumor Mic
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116 6 Immune Cells in the Tumor Mic
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122 7 Immunosuppresive Factors in C
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150 7 Immunosuppresive Factors in C
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156 8 Interleukin-10 in Cancer Immu
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158 8 Interleukin-10 in Cancer Immu
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160 8 Interleukin-10 in Cancer Immu
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162 8 Interleukin-10 in Cancer Immu
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180 9 Dendritic Cells and Cancer: P
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184 9 Dendritic Cells and Cancer: P
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204 Cancer Immune Therapie: Current
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208 10 The Immune System in Cancer:
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210 10 The Immune System in Cancer:
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212 10 The Immune System in Cancer:
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216 10 The Immune System in Cancer:
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220 10 The Immune System in Cancer:
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222 10 The Immune System in Cancer:
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224 10 The Immune System in Cancer:
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226 10 The Immune System in Cancer:
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228 10 The Immune System in Cancer:
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230 Cancer Immune Therapie: Current
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232 11 Hybrid Cell Vaccination for
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234 11 Hybrid Cell Vaccination for
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236 11 Hybrid Cell Vaccination for
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238 11 Hybrid Cell Vaccination for
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348 17 Immunotoxins and Recombinant
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350 17 Immunotoxins and Recombinant
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352 17 Immunotoxins and Recombinant
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376 17 Immunotoxins and Recombinant
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378 17 Immunotoxins and Recombinant
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380 Cancer Immune Therapie: Current
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382 Glossary tion to the variable d
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384 Glossary suppressor gene produc
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386 Glossary press the proper recep
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388 Glossary gp96 See Chaperone. Gr
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390 Glossary cytes and addressing l
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392 Glossary T bodies are being tes