Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...

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XVIII List of Contributors Prof. Dr. med. M. Pfreundschuh Med. Klinik und Poliklinik, Innere Medizin I Universitåtsklinikum Saarland 66421 Homburg Germany Ralph A. Reisfeld The Scripps Research Institute 10550 North Torrey Pines Road, IMM-13 La Jolla, CA 92037 USA Dr. Yoram Reiter Faculty of Biology Technion-Israel Institute of Technology Room 333, Technion City Haifa 32000 Israel Dr. Pedro Romero Division of Clinical OncoImmunology Ludwig Institute for Cancer Research HÖpital Orthop dique, Niveau 5 Aile Est, Avenue Pierre Decker, 4 1005 Lausanne Switzerland Robert Sabat and Khusru Asadullah Research Business Area Dermatology Schering AG Mçllerstr. 178 13342 Berlin Germany Barbara Seliger and Ulrike Ritz Johannes Gutenberg University III. Department of Internal Medicine Langenbeckstr. 1 55101 Mainz Germany Richard G. Vile Molecular Medicine Program Guggenheim 18, Mayo Foundation 200 First Street SW Rochester, MI 55902 USA Dr. Robert H. Vonderheide, MD., D.Phil. Abramson Family Cancer Research Institute University of Pennsylvania Cancer Center Philadelphia, PA 19104 USA Prof. Dr. Peter Walden Universitåtsklinikum Humboldt Universitåt Berlin Campus Charit Mitte, Klinik fçr Dermatologie Schumannstr. 20/21 10117 Berlin Germany Theresa L. Whiteside, Ph.D. W1041 Biomedical Science Tower 200 Lothrop Street Pittsburgh, PA 15213-2582 USA
Color Plates Fig. 5.2 The MHC class I APM. Ubiquitinylated proteins are cleaved into peptides by the multicatalytic proteasome subunits which are then transported via the TAP heterocomplex into the ER. In the ER, peptides assemble with the MHC class I HC and b 2-m to form the trimeric MHC class I complex, which is then transported through the Golgi complex to the cell surface for presentation to CD8 + cytotoxic T cells (A). The MHC class I/peptide assembly is assisted by various chaperones, such as calnexin, calreticulin, ERp57 and tapasin, which partially form the multimeric TAP complex (B). Cancer Immune Therapie: Current and Future Strategies Edited by G. Stuhler and P. Walden Copyright # 2002 Wiley-VCH Verlag GmbH & Co. KGaA ISBNs: 3-527-30441-X (Hardback); 3-527-60079-5 (Electronic) XIX
Page 1 and 2: Cancer Immune Therapie: Current and
Page 3 and 4: Editors: Dr. Gernot Stuhler Univers
Page 5 and 6: VI Preface Recent years have seen a
Page 7 and 8: VIII Contents 2.5.3 Antigens Encode
Page 9 and 10: X Contents 6.4.2 Natural Killer (NK
Page 11 and 12: XII Contents 9.6 Loading DC with An
Page 13 and 14: XIV Contents 14.2.2.1 Cancer-specif
Page 15: List of Contributors Richard Bucala
Page 19 and 20: Fig. 5.5 Different immune effector
Page 21 and 22: Fig. 5.17 Possible pathway for the
Page 23 and 24: Fig. 6.2 T lymphocytes in the tumor
Page 25 and 26: Index a acidic and basic fibroblast
Page 27 and 28: ±, see also tumors cationic lipids
Page 29 and 30: e EBV see Epstein-Barr virus EDR se
Page 31 and 32: immature Mo-DCs 184 immune cells ±
Page 33 and 34: MHC class I antigen-processing mach
Page 35 and 36: ±, onco- 209 ±, over-expressed ce
Page 37 and 38: TICD see tumor-induced cell death T
Page 39 and 40: Part 1 Tumor Antigenicity Cancer Im
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30 Cancer Immune Therapie: Current
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32 3 Processing and Presentation of
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42 4 T Cells In Tumor Immunity cult
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44 4 T Cells In Tumor Immunity cell
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46 4 T Cells In Tumor Immunity to T
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48 4 T Cells In Tumor Immunity Alth
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50 4 T Cells In Tumor Immunity Tab.
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52 4 T Cells In Tumor Immunity rest
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54 4 T Cells In Tumor Immunity 53 T
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Part 2 Immune Evasion and Suppressi
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60 5 Major Histocompatibility Compl
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68 Tab. 5.1 HLA class I loss attrib
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96 6 Immune Cells in the Tumor Micr
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98 6 Immune Cells in the Tumor Micr
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100 6 Immune Cells in the Tumor Mic
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Part 3 Strategies for Cancer Immuno
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270 13 Applications of CpG Motifs f
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348 17 Immunotoxins and Recombinant
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382 Glossary tion to the variable d
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384 Glossary suppressor gene produc
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386 Glossary press the proper recep
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388 Glossary gp96 See Chaperone. Gr
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390 Glossary cytes and addressing l
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392 Glossary T bodies are being tes
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