Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...

In summary, these computer-assisted approaches enable a rapid and easy identification
of CTL epitopes that can be included in the proposed CTL-inducing vaccine and
will help the selection of epitope flanking spacers that improve proteasome-mediated
epitope processing. The existing proteasome cleavage programs are currently being
tested for general applicability, whereby the availability of new cleavage data obtained
through in vitro digestion of designed constructs with purified proteasomes in turn
will allow the designers to improve their programs.
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