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Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...

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elevance of tumor-related/specific autoantibodies in patients` sera <strong>and</strong> of antigen expression<br />

in tumors, as well as the correlation with CTL responses <strong>and</strong> specific T<br />

helper cells. Well-designed clinical trials will answer the question whether our increased<br />

knowledge about these antigens can be translated into immuno- <strong>and</strong> gene<br />

therapeutic strategies with an improved prognosis for patients with malignant disease<br />

not curable <strong>by</strong> current st<strong>and</strong>ard therapy. Finally, the knowledge of the functional<br />

role of cancer-associated antigens provides us with a more profound insight into genetic<br />

<strong>and</strong> molecular alterations that play a role in the pathogenesis <strong>and</strong> growth of<br />

cancer.<br />

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27

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