Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...

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XXVI Color Plates Fig. 9.1 The DC Life Cycle. Hematopoietic stem cells in bone marrow produce DCs into the blood stream. Blood myeloid DCs and lymphoid DCs use adhesion molecules and chemokine receptors (CD62L, CXCR3 and CCR5) to traffic to peripheral tissues (CD11c + myeloid) or directly to lymph nodes (DC123 + lymphoid) via HEVs. In peripheral tissues immature myeloid DCs which encounter antigens and accompany microbial products (TNFand lipopolysaccharide) and signals from activated Tcells (CD40L) start to differentiate. These DCs move toward lymphatics using chemokine receptors (CCR7), whose ligand SLC, is found both in lymphatic endothelium and in secondary lymphoid tissue. In the lymph node mature DCs produce chemokines, which attract naive and activated Tcells. Complex interactions with the local microenvironment (perhaps including lymphoid DCs) increase co-stimulatory molecules, optimize antigen presentation, and induce further lymphocyte activation and the production of effector and memory T lymphocytes. DCs also contribute to B lymphocyte activation and antibody production.
Index a acidic and basic fibroblast growth factor see fibroblast growth factor activation-induced cell death (AICD) 110, 114, 234 ±, effects of TGF-b 123 acute lymphocytic leukemia (ALL) 302 acute myelocytic leukemia (AML) 302, 305f. adaptive immunity, HSPs 253 ADCC see antibody-dependent cellular cytotoxicity add-back strategy, DLIs 306 adjuvants, definition 223 adoptive immunotherapy 301 adoptive T immunotherapy 5 adoptive transfer therapy 41 AICD see activation-induced cell death ALL see acute lymphocytic leukemia allogenic stem cell transplants 197 allogenic transplantation 361 allospecifities, MHC class I antigens 72 AML see acute myelocytic leukemia amplified-gene encoded antigens 22 angiogenesis ±, COX inhibitors 132 ±, effects of IL-10 165 antiangiogenesis, immunocytokines 341f. anti-asialo-GM1 antiserum 274 antibodies ±, anti-IL-10 129 ±, auto- 214 ±, bacterial immunotherapy 274 ±, cancer-specific 290 ±, discovery 311 ±, monoclonal 17f., 277, 363±366 ±, side effects of DC vaccinations 194 ±, T-body approach 287 antibody 17-1A 313 antibody-cytokine fusion proteins 311f. antibody-dependent cellular cytotoxicity (ADCC) 277 Cancer Immune Therapie: Current and Future Strategies Edited by G. Stuhler and P. Walden Copyright # 2002 Wiley-VCH Verlag GmbH & Co. KGaA ISBNs: 3-527-30441-X (Hardback); 3-527-60079-5 (Electronic) antibody-dependent cytotoxicity 314 antibody fragments ±, immunotoxins 363±366 ±, recombinant 354±357 antibody incidence, SEREX antigens 23 antibody responses, clinical significance 23 anti-CD20 antibody rituximab 17 antigen, definition 223 antigen identification 41±44 antigen loading, dendritic cells 186f. antigen loss ±, immunocytokines 331 ±, MHC class I 66±69, 72±76 antigen presentation 30±39, 209ff. ±, MHC pathway 59±62 antigen-presenting cells (APCs) 105, 210±214, 233 ±, bacterial immunotherapy 276f. ±, dendritic cells 196 ±, effects of IL-10 158f. ±, HCV 239ff. ±, HSPs 258, 263 ±, immunocytokines 318, 320 ±, tumor cell killing 220 antigen processing 30±39 ±, MHC pathway 59±62 antigen-processing machinery (APM) 60ff. ±, MHC class I 70 ±, MHC class II 79ff. antigen release, tumor cell killing 219f. antigenic complexity, of tumor cells 235 antigenic peptides, HSPs 254f. antigenicity ±, tumor 3±55, 155, 231ff. antigens ±, auto- 214 ±, foreign 211, 224 ±, near-self 224 ±, self- 207, 209, 224 ±, SEREX 19±27 ±, shared 256 395
Page 1 and 2: Cancer Immune Therapie: Current and
Page 3 and 4: Editors: Dr. Gernot Stuhler Univers
Page 5 and 6: VI Preface Recent years have seen a
Page 7 and 8: VIII Contents 2.5.3 Antigens Encode
Page 9 and 10: X Contents 6.4.2 Natural Killer (NK
Page 11 and 12: XII Contents 9.6 Loading DC with An
Page 13 and 14: XIV Contents 14.2.2.1 Cancer-specif
Page 15 and 16: List of Contributors Richard Bucala
Page 17 and 18: Color Plates Fig. 5.2 The MHC class
Page 19 and 20: Fig. 5.5 Different immune effector
Page 21 and 22: Fig. 5.17 Possible pathway for the
Page 23: Fig. 6.2 T lymphocytes in the tumor
Page 27 and 28: ±, see also tumors cationic lipids
Page 29 and 30: e EBV see Epstein-Barr virus EDR se
Page 31 and 32: immature Mo-DCs 184 immune cells ±
Page 33 and 34: MHC class I antigen-processing mach
Page 35 and 36: ±, onco- 209 ±, over-expressed ce
Page 37 and 38: TICD see tumor-induced cell death T
Page 39 and 40: Part 1 Tumor Antigenicity Cancer Im
Page 41 and 42: 4 1 Search for Universal Tumor-Asso
Page 47 and 48: 10 1 Search for Universal Tumor-Ass
Page 55 and 56: 18 2 Serological Determinants On Tu
Page 67 and 68: 30 Cancer Immune Therapie: Current
Page 69 and 70: 32 3 Processing and Presentation of
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38 3 Processing and Presentation of
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40 Cancer Immune Therapie: Current
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42 4 T Cells In Tumor Immunity cult
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44 4 T Cells In Tumor Immunity cell
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46 4 T Cells In Tumor Immunity to T
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48 4 T Cells In Tumor Immunity Alth
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50 4 T Cells In Tumor Immunity Tab.
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52 4 T Cells In Tumor Immunity rest
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54 4 T Cells In Tumor Immunity 53 T
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Part 2 Immune Evasion and Suppressi
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60 5 Major Histocompatibility Compl
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68 Tab. 5.1 HLA class I loss attrib
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96 6 Immune Cells in the Tumor Micr
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98 6 Immune Cells in the Tumor Micr
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100 6 Immune Cells in the Tumor Mic
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Tab. 7.1 Effects of tumor-derived m
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122 7 Immunosuppresive Factors in C
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156 8 Interleukin-10 in Cancer Immu
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Part 3 Strategies for Cancer Immuno
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180 9 Dendritic Cells and Cancer: P
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206 10 The Immune System in Cancer:
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232 11 Hybrid Cell Vaccination for
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254 12 Principles and Strategies Em
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270 13 Applications of CpG Motifs f
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288 14 The T-Body Approach: Towards
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300 15 Bone Marrow Transplantation
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312 16 Immunocytokines: Versatile M
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348 17 Immunotoxins and Recombinant
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382 Glossary tion to the variable d
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384 Glossary suppressor gene produc
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386 Glossary press the proper recep
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388 Glossary gp96 See Chaperone. Gr
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390 Glossary cytes and addressing l
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392 Glossary T bodies are being tes
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