Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...

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immunity in patients affected by recurrent disease after allogeneic bone marrow transplantation. Hum Gen Ther 1995; 2: 813±819. 25 Bonini C, Ferrari G,Verzeletti S, et al. HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science 1997; 276: 1719±1724. 26 Bordignon C, Notarangelo LD, Nobili N, et al. Gene therapy in peripheral blood lymphocytes and bone marrow for ADA-immunodeficient patients. Science 1995; 270: 470±475. 27 Bonini C, Ciceri F, Marktel S, Bordignon C. Suicide-gene-transduced Tcells for the regulation of the graft-versus-leukemia effect [Review]. Vox Sang 1998; 74 (suppl 2): 341±343. 28 Tiberghien P. Use of donor T-lymphocytes expressing herpes-simplex thymidine kinase in allogeneic bone marrow transplantation: a phase I±II study. Hum Gene Ther 1997; 8: 615±624. 29 Tiberghien P, Ferrand C, Lioure B, et al. Administration of herpes simplexthymidine kinase-expressing donor T cells with a T-cell depleted allogeneic marrow graft. Blood 2001; 97: 63±72. 30 Champlin R, Besinger W, Henslee- Downey J, et al. Phase I/II study of thymidine kinase (TK)-transduced donor lymphocyte infusions (DLI) in patients with hematologic malignancies. Blood 1999; 94: 1448a. 31 Verzelletti S, Bonini C, Marktel S, et al. Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: clinical follow-up and improved new vectors. Hum Gene Ther 1998; 9: 2243±2251. 32 Aversa F, Tabilio A,Velardi A, et al. Treatment of high risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Engl J Med 1998; 339: 1186±1193. 33 Klingemann HG, Storb R, Fefer A, et al. Bone marrow transplantation in patients aged 45 years and older. Blood 1986; 67: 770. 34 Tsai T, Goodman S, Saez R, et al. Allogeneic bone marrow transplantation in References patients who relapse after autologous transplantation. Bone Marrow Transplant 1997; 20: 859. 35 Giralt S, Thall PF, Khouri I, et al. Engraftment of allogeneic hematopoietic progenitor cells with purine analogcontaining chemotherapy: harnessing graft-versus-leukemia without myeloablative therapy. Blood 1997; 89: 4531± 4536. 36 Slavin S, Nagler A, Naparstek E, et al. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood 1998; 91: 756±763. 37 Khouri IF, Keating M, Korbling M, et al. Transplant-lite: induction of graftversus-malignancy using fludarabinebased nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies. J Clin Oncol 1998; 16: 2817±2824. 38 McSweeney PA, Niederwieser D, Shizuru JA, et al. Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing highdose cytotoxic therapy with graft-versustumor effect. Blood 2001; 97: 3390± 3400. 39 Carella AM, Cavaliere M, Lerma E, et al. Autografting followed by nonmyeloablative immunosuppressive chemotherapy and allogeneic peripheralblood hematopoietic stem-cell transplantation as treatment of resistant Hodgkin's disease and non-Hodgkin's lymphoma. J Clin Oncol 1000; 18: 3918. 40 Nagler A, Slavin S,Varadi G, et al. Allogeneic peripheral blood stem cell transplantation using fludarabine-based low intensity conditioning regimen for malignant lymphoma. Bone Marrow Transplant 2000; 25: 1021. 41 Raiola AM,Van Lint MT, Lamparelli T, et al. Reduced intensity thiotepa-cyclophosphamide conditioning for allogeneic haemopoietic stem cell transplants (HSCT) in patients up to 60 years of age. Br J Haematol 109: 716, 2000. 309
310 15 Bone Marrow Transplantation for Immune Therapy 42 Kottaridis PD, Milligan DW, Chopra R, et al. In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation. Blood 2000; 96: 2419±2425. 43 Corradini P, Tarella C, Olivieri A, et al. Reduced intensity conditioning followed by allografting of hematopoietic cells can produce clinical and molecular remissions in patients with poorrisk hematologic malignancies. Blood, in press. nupdate?n 44 Childs R, Drachenberg D. Allogeneic stem cell transplantation for renal cell carcinoma [Review]. Curr Opin Urol 2001; 11: 495±502. 45 Childs R, Chernoff A, Contentin N, et al. Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. N Engl J Med 2000; 343: 750±758.
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Cancer Immune Therapie: Current and
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Editors: Dr. Gernot Stuhler Univers
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VI Preface Recent years have seen a
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VIII Contents 2.5.3 Antigens Encode
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X Contents 6.4.2 Natural Killer (NK
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XII Contents 9.6 Loading DC with An
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XIV Contents 14.2.2.1 Cancer-specif
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List of Contributors Richard Bucala
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Color Plates Fig. 5.2 The MHC class
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Fig. 5.5 Different immune effector
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Fig. 5.17 Possible pathway for the
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Fig. 6.2 T lymphocytes in the tumor
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Index a acidic and basic fibroblast
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±, see also tumors cationic lipids
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e EBV see Epstein-Barr virus EDR se
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immature Mo-DCs 184 immune cells ±
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MHC class I antigen-processing mach
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±, onco- 209 ±, over-expressed ce
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TICD see tumor-induced cell death T
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Part 1 Tumor Antigenicity Cancer Im
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4 1 Search for Universal Tumor-Asso
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10 1 Search for Universal Tumor-Ass
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18 2 Serological Determinants On Tu
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30 Cancer Immune Therapie: Current
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32 3 Processing and Presentation of
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42 4 T Cells In Tumor Immunity cult
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44 4 T Cells In Tumor Immunity cell
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46 4 T Cells In Tumor Immunity to T
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48 4 T Cells In Tumor Immunity Alth
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50 4 T Cells In Tumor Immunity Tab.
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52 4 T Cells In Tumor Immunity rest
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54 4 T Cells In Tumor Immunity 53 T
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Part 2 Immune Evasion and Suppressi
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60 5 Major Histocompatibility Compl
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68 Tab. 5.1 HLA class I loss attrib
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96 6 Immune Cells in the Tumor Micr
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98 6 Immune Cells in the Tumor Micr
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100 6 Immune Cells in the Tumor Mic
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Tab. 7.1 Effects of tumor-derived m
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122 7 Immunosuppresive Factors in C
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156 8 Interleukin-10 in Cancer Immu
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Part 3 Strategies for Cancer Immuno
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180 9 Dendritic Cells and Cancer: P
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206 10 The Immune System in Cancer:
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232 11 Hybrid Cell Vaccination for
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254 12 Principles and Strategies Em
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256 12 Principles and Strategies Em
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Page 303 and 304: 270 13 Applications of CpG Motifs f
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Page 333 and 334: 300 15 Bone Marrow Transplantation
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Page 345 and 346: 312 16 Immunocytokines: Versatile M
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360 17 Immunotoxins and Recombinant
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382 Glossary tion to the variable d
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384 Glossary suppressor gene produc
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386 Glossary press the proper recep
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388 Glossary gp96 See Chaperone. Gr
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390 Glossary cytes and addressing l
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392 Glossary T bodies are being tes
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