Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...

Color Plates
Fig. 5.2 The MHC class I
APM. Ubiquitinylated proteins
are cleaved into peptides by the
multicatalytic proteasome subunits
which are then transported
via the TAP heterocomplex
into the ER. In the ER, peptides
assemble with the MHC
class I HC and b 2-m to form the
trimeric MHC class I complex,
which is then transported
through the Golgi complex to
the cell surface for presentation
to CD8 + cytotoxic T cells (A).
The MHC class I/peptide assembly
is assisted by various
chaperones, such as calnexin,
calreticulin, ERp57 and tapasin,
which partially form the multimeric
TAP complex (B).
Cancer Immune Therapie: Current and Future Strategies
Edited by G. Stuhler and P. Walden
Copyright # 2002 Wiley-VCH Verlag GmbH & Co. KGaA
ISBNs: 3-527-30441-X (Hardback); 3-527-60079-5
(Electronic)
XIX