Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...

Contents
List of Contributors XVII
Color Plates XIX
Part 1 Tumor Antigenicity
Cancer Immune Therapie: Current and Future Strategies
Edited by G. Stuhler and P. Walden
Copyright # 2002 Wiley-VCH Verlag GmbH & Co. KGaA
ISBNs: 3-527-30441-X (Hardback); 3-527-60079-5
(Electronic)
1 Search for Universal Tumor-Associated T Cell Epitopes 3
Robert H. Vonderheide and Joachim L. Schultze
1.1 Introduction 3
1.2 T Cell Epitopes as the Basis for Anti-Cancer Therapy 4
1.3 Identification of Tumor-Associated Antigens 5
1.4 Search for Universal Tumor Antigens 6
1.5 Epitope Deduction 6
1.6 Identification of the Telomerase Reverse Transcriptase (hTERT) as a
Widely Expressed Tumor-Associated Antigen 8
1.7 Linking Cancer Genomics to Cancer Immunotherapy 10
1.8 Prospects for Additional Universal Tumor Antigens 11
1.9 Prospect of Universal Tumor Antigens as a Clinical Target for
Immunotherapy 11
1.10 Conclusions 12
References 13
2 Serological Determinants On Tumor Cells 17
Carsten Zwick, Klaus-Dieter Preuss, Claudia Bormann,
Frank Neumann and Michael Pfreundschuh
2.1 Introduction 17
2.2 SEREX: The Approach 18
2.3 Searching for Human Antigens by SEREX 19
2.4 Molecular Characterization of SEREX Antigens 19
2.5 Specificity of SEREX Antigens 20
2.5.1 Shared Tumor Antigens 20
2.5.2 Differentiation Antigens 21
VII