Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...

Fig. 6.2 T lymphocytes in the tumor
microenvironment. In (A), a mass of
HLA-DR + T cells surrounds the tumor.
Immunoperoxidase staining of the
biopsy obtained from a patient with
head and neck cancer. Original magnification:
× 400. In (B), a cluster of CD8 + T
cells (red) infiltrating a human head and
neck cancer. Apoptotic T cells (TUNEL +
whitish) are evident among the CD8 + T
cells. A TUNEL reagent was used in
combination with immunoperoxidase
staining. Original magnification: × 400.
Dr T. E. Reichert, U. Mainz, Germany
contributed Fig. 2(B).
Color Plates
Fig. 8.1 Effects of IL-10 on APC±T cell interaction. IL-10 suppresses the
expression of pro-inflammatory cytokines and enhances the formation of
anti-inflammatory mediators. Moreover, IL-10 inhibits the capacity of
monocytes and macrophages to present antigen to T cells.
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