Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...

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duce antitumor immunity. J Immunol 2000; 165: 1705±11. 158 Gong J, Avigan D, Chen D,Wu Z, Koido S, Kashiwaba M, Kufe D. Activation of antitumor cytotoxic T lymphocytes by fusions of human dendritic cells and breast carcinoma cells. Proc Natl Acad Sci USA 2000; 97: 2715±8. 159 Gong J, Chen D, Kashiwaba M, Li Y, Chen L, Takeuchi H, Qu H, Rowse GJ, Gendler SJ, Kufe D. Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells. Proc Natl Acad Sci USA 1998; 95: 6279±83. 160 Yee C, Thompson JA, Roche P, Byrd DR, Lee PP, Piepkorn M, Kenyon K, Davis MM, Riddell SR, Greenberg PD. Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of t cellmediated vitiligo. J Exp Med 2000; 192: 1637±44. 161 Stuhler G and Walden P. Recruitment of helper T cells for induction of tumor rejection by cytolytic T lymphocytes. Cancer Immunol Immunother 1994; 39: 342±5. 162 Guo Y,Wu M, Chen H,Wang X, Liu G, Li G, Ma J, Sy MS. Effective tumor vaccine generated by fusion of hepatoma cells with activated B cells. Science 1994; 263: 518±20. 163 Stuhler G, Trefzer U,Walden P. Hybrid cell vaccination in cancer immunotherapy. Recruitment and activation of T cell help for induction of anti tumour cytotoxic T cells. Adv Exp Med Biol 1998; 451: 277±82. 164 Satthaporn S, Eremin O. Dendritic cells (I): biological functions. J R Coll Surg Edinb 2001; 46: 9±19. 165 Satthaporn S, Eremin O. Dendritic cells (II): role and therapeutic implications in cancer. J R Coll Surg Edinb 2001; 46: 159±67. 166 Scott-Taylor TH, Pettengell R, Clarke I, Stuhler G, La Barthe MC, Walden P, Dalgleish AG. Human tumor and dendritic cell hybrids generated by electrofusion: potential for cancer vaccines. Biochim Biophys Acta 2000; 1500:2 65±79. References 167 Trefzer U,Weingart G, Sterry W, Walden P. Hybrid cell vaccination in patients with metastatic melanoma. Methods Mol Med. 2000; 35: 469±75. 168 Tanaka Y, Koido S, Chen D, Gendler SJ, Kufe D, Gong J. Vaccination with allogeneic dendritic cells fused to carcinoma cells induces antitumor immunity in MUC1 transgenic mice. Clin Immunol 2001; 101:192±200. 169 Souberbielle BE,Westby M, Ganz S, Kayaga J, Mendes R, Morrow WJ, Dalgleish AG. Comparison of four strategies for tumour vaccination in the B16-F10 melanoma model. Gene Ther 1998; 5: 1447±54. 170 Dunnion DJ, Cywinski AL,Tucker VC, Murray AK, Rickinson AB, Coulie P, Browning MJ. Human antigen-presenting cell/tumor cell hybrids stimulate strong allogeneic responses and present tumor-associated antigens to cytotoxic Tcells in vitro. Immunology 1999; 98: 541±50. 171 Trefzer U,Weingart G, Chen Y, Herberth G, Adrian K,Winter H, Audring H, Guo Y, Sterry W,Walden P. Hybrid cell vaccination for cancer immune therapy: first clinical trial with metastatic melanoma. Int J Cancer 2000; 85: 618±26. 172 Trefzer U, Herberth G, Sterry W, Walden P. The hybrid cell vaccination approach to cancer immunotherapy. Ernst Schering Res Found Workshop 2000; 30: 154±66. 173 Kugler A, Seseke F, Thelen P, Kallerhoff M, Muller GA, Stuhler G, Muller C, Ringert RH. Autologous and allogenic hybrid cell vaccine in patients with metastatic renal cell carcinoma. Br J Urol 1998; 82: 487±93. 174 Gilboa E, Nair SK, Lyerly HK. Immunotherapy of cancer with dendritic-cellbased vaccines. Cancer Immunol Immunother 1998; 46: 82±7. 175 Ashley DM, Faiola B, Nair S, Hale LP, Bigner DD, Gilboa E. Bone marrowgenerated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors. J Exp Med 1997; 186: 1177±82. 251
252 11 Hybrid Cell Vaccination for Cancer Immune Therapy 176 Porgador A, Gilboa E. Bone marrowgenerated dendritic cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes. J Exp Med 1995; 182: 255±60. 177 Nair SK, Boczkowski D, Snyder D, Gilboa E. Antigen-presenting cells pulsed with unfractionated tumor-derived peptides are potent tumor vaccines. Eur J Immunol 1997; 27: 589±97. 178 Boczkowski D, Nair SK, Snyder D, Gilboa E. Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. J Exp Med 1996; 184: 465±72. 179 Boczkowski D, Nair SK, Nam JH, Lyerly HK, Gilboa E. Induction of tumor immunity and cytotoxic T lymphocyte responses using dendritic cells transfected with messenger RNA amplified from tumor cells. Cancer Res 2000; 60: 1028±34. 180 Heiser A, Maurice MA,Yancey DR, Wu NZ, Dahm P, Pruitt SK, Boczkowski D, Nair SK, Ballo MS, Gilboa E,Vieweg J. Induction of polyclonal prostate cancer-specific CTL using dendritic cells transfected with amplified tumor RNA. J Immunol 2001; 166: 2953±60.
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Cancer Immune Therapie: Current and
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Editors: Dr. Gernot Stuhler Univers
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VI Preface Recent years have seen a
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VIII Contents 2.5.3 Antigens Encode
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X Contents 6.4.2 Natural Killer (NK
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XII Contents 9.6 Loading DC with An
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XIV Contents 14.2.2.1 Cancer-specif
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List of Contributors Richard Bucala
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Color Plates Fig. 5.2 The MHC class
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Fig. 5.5 Different immune effector
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Fig. 5.17 Possible pathway for the
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Fig. 6.2 T lymphocytes in the tumor
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Index a acidic and basic fibroblast
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±, see also tumors cationic lipids
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e EBV see Epstein-Barr virus EDR se
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immature Mo-DCs 184 immune cells ±
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MHC class I antigen-processing mach
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±, onco- 209 ±, over-expressed ce
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TICD see tumor-induced cell death T
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Part 1 Tumor Antigenicity Cancer Im
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4 1 Search for Universal Tumor-Asso
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10 1 Search for Universal Tumor-Ass
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18 2 Serological Determinants On Tu
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30 Cancer Immune Therapie: Current
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32 3 Processing and Presentation of
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42 4 T Cells In Tumor Immunity cult
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44 4 T Cells In Tumor Immunity cell
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46 4 T Cells In Tumor Immunity to T
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48 4 T Cells In Tumor Immunity Alth
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50 4 T Cells In Tumor Immunity Tab.
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52 4 T Cells In Tumor Immunity rest
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54 4 T Cells In Tumor Immunity 53 T
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Part 2 Immune Evasion and Suppressi
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60 5 Major Histocompatibility Compl
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68 Tab. 5.1 HLA class I loss attrib
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96 6 Immune Cells in the Tumor Micr
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98 6 Immune Cells in the Tumor Micr
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100 6 Immune Cells in the Tumor Mic
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Tab. 7.1 Effects of tumor-derived m
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122 7 Immunosuppresive Factors in C
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156 8 Interleukin-10 in Cancer Immu
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Part 3 Strategies for Cancer Immuno
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180 9 Dendritic Cells and Cancer: P
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Page 233 and 234: 200 9 Dendritic Cells and Cancer: P
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Page 237 and 238: 204 Cancer Immune Therapie: Current
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Page 265 and 266: 232 11 Hybrid Cell Vaccination for
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Page 321 and 322: 288 14 The T-Body Approach: Towards
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302 15 Bone Marrow Transplantation
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312 16 Immunocytokines: Versatile M
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348 17 Immunotoxins and Recombinant
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382 Glossary tion to the variable d
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384 Glossary suppressor gene produc
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386 Glossary press the proper recep
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388 Glossary gp96 See Chaperone. Gr
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390 Glossary cytes and addressing l
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392 Glossary T bodies are being tes
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