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Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...

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152 7 Immunosuppresive Factors in <strong>Cancer</strong><br />

difluoromethylornithine in lung metastases<br />

before <strong>and</strong> after surgery of primary<br />

adenocarcinoma tumors in mice.<br />

Biol. Cell 53: 33.<br />

273 Sunkara, P. S. <strong>and</strong> A. L. Rosenberger.<br />

1987. Antimetastatic activity of dl-a-difluoromethylornithine,<br />

an inhibitor of<br />

polyamine biosynthesis, in mice. <strong>Cancer</strong><br />

Res. 47: 933.<br />

274 Marx, M., C. M. J. Townsend,<br />

S. C. Barranco, E. J. Glass <strong>and</strong><br />

J. C. Thompson. 1987. Treatment of<br />

hamster pancreatic cancer with a-difluoromethylornithine,<br />

an inhibitor of<br />

polyamine biosynthesis. J. Natl <strong>Cancer</strong><br />

Inst. 79: 543.<br />

275 Upp, J. R. J., R. D. Beauchamp, C. M. J.<br />

Townsend, S. C. Barranco, P. Singh,<br />

S. Rajaraman, E. James <strong>and</strong> J. C. Thompson.<br />

1988. Inhibition of human gastric<br />

adenocarcinoma xenograft growth in<br />

nude mice <strong>by</strong> a-difluoromethylornithine.<br />

<strong>Cancer</strong> Res. 48: 3265.<br />

276 Prakash, N. J., T. L. Bowlin, G. F. Davis,<br />

P. S. Sunkara <strong>and</strong> A. Sjoerdsma.<br />

1988. Antitumor activity of norspermidine,<br />

a structural homologue of the natural<br />

polyamine spermidine. Anticancer<br />

Res. 8: 563.<br />

277 Andersson, G. <strong>and</strong> O. He<strong>by</strong>. 1977. Population<br />

kinetics of an Ehrlich ascites<br />

tumor following treatment with methylglyoxal-bis(guanylhydrazone),<br />

a polyamine<br />

synthesis inhibitor. <strong>Cancer</strong> Lett. 3:<br />

59.<br />

278 Luk, G. D., G. Goodwin, L. J. Marton<br />

<strong>and</strong> S. B. Baylin. 1981. Polyamines are<br />

necessary for the survival of human<br />

small-cell lung carcinoma in culture.<br />

Proc. Natl Acad. Sci. USA 78: 2355.<br />

279 Manni, A. <strong>and</strong> C. Wright. 1983. Effect<br />

of tamoxifen <strong>and</strong> a-difluoromethylornithine<br />

on clones of nitrosomethylureainduced<br />

rat mammary tumor cells<br />

grown in soft agar culture. <strong>Cancer</strong> Res.<br />

43: 1084.<br />

280 Manni, A. <strong>and</strong> C. Wright. 1984. Reversal<br />

of the antiproliferative effect of<br />

the antiestrogen tamoxifen <strong>by</strong> polyamines<br />

in breast cancer cells. Endocrinology<br />

114: 836.<br />

281 Seidenfeld, J., A. L. Block, K. A. Komar<br />

<strong>and</strong> M. F. Naujokas. 1986. Altered<br />

cell cycle phase distributions in cul-<br />

tured human carcinoma cells partially<br />

depleted of polyamines <strong>by</strong> treatment<br />

with difluoromethylornithine. <strong>Cancer</strong><br />

Res. 46: 47.<br />

282 Sunkara, P. S., C. C. Chang, N. J. Prakash<br />

<strong>and</strong> P. J. Lachmann. 1985. Effect<br />

of inhibition of polyamine biosynthesis<br />

<strong>by</strong> dl-a-difluoromethylornithine on the<br />

growth <strong>and</strong> melanogenesis of B16 melanoma<br />

in vitro <strong>and</strong> in vivo. <strong>Cancer</strong> Res.<br />

45: 4067.<br />

283 Wallon, U. M., L. R. Shassetz,<br />

A. E. Cress, G. T. Bowden <strong>and</strong> E. W. Gerner.<br />

1994. Polyamine-dependent expression<br />

of the matrix metalloproteinase matrilysin<br />

in a human colon cancer-derived<br />

cell line. Mol. Carcinogen. 11: 138.<br />

284 Kubota, S., H. Kiyosawa,Y. Nomura, T.<br />

Yamada <strong>and</strong> Y. Seyama. 1997. Ornithine<br />

decarboxylase overexpression in mouse<br />

10T1/2 fibroblasts: cellular transformation<br />

<strong>and</strong> invasion. J. Natl <strong>Cancer</strong> Inst.<br />

89: 567.<br />

285 McCloskey, D. E., J. Yang, P. M.Woster,<br />

N. E. Davidson <strong>and</strong> R. A. J. Casero.<br />

1996. Polyamine analogue induction of<br />

programmed cell death in human lung<br />

tumor cells. Clin. <strong>Cancer</strong> Res. 2: 441.<br />

286 Kaneko, H., H. Hibasami, K. Mori,<br />

Y. Kawarada <strong>and</strong> K. Nakashima. 1998.<br />

Apoptosis induction in human breast<br />

cancer MRK-nu-1 cells <strong>by</strong> a polyamine<br />

synthesis inhibitor, methylglyoxal bis<br />

(cyclopentylamidino-hydrazone)<br />

(MGBCP). Anticancer Res. 18: 891.<br />

287 Holtta, E., M. Auvinen <strong>and</strong> L. C. Andersson.<br />

1993. Polyamines are essential<br />

for cell transformation <strong>by</strong> pp60vsrc:<br />

delineation of molecular events relevant<br />

for the transformed phenotype.<br />

J. Cell Biol. 122: 903.<br />

288 Tabib, A. <strong>and</strong> U. Bachrach. 1998. Polyamines<br />

induce malignant transformation<br />

in cultured NIH 3T3 fibroblasts.<br />

Int. J. Biochem. Cell Biol. 30: 135.<br />

289 Tabib, A. <strong>and</strong> U. Bachrach. 1999. Role<br />

of polyamines in mediating malignant<br />

transformation <strong>and</strong> oncogene expression.<br />

Int. J. Biochem. Cell Biol. 31: 1289.<br />

290 Iwata, S.,Y. Sato, M. Asada, M. Takagi,<br />

A. Tsujimoto, T. Inaba, T. Yamada,<br />

S. Sakamoto, J. Yata, T. Shimogori,<br />

K. Igarashi <strong>and</strong> S. Mizutani. 1999.<br />

Anti-tumor activity of antizyme which

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