79 C. E. Touloukian,W. W. Leitner, S. L. Topalian,Y. F. Li, P. F. Robbins, S. A. Rosenberg, N. P. Restifo, JImmunol 2000; 164: 3535. 80 R. F. Wang, X. Wang, A. C. Atwood, S. L. Topalian, S. A. Rosenberg, Science 1999; 284: 1351. 81 P. Chaux,V. Vantomme,V. Stroobant, K. Thielemans, J. Corthals, R. Luiten, A. M. Eggermont,T. Boon, P. van der Bruggen, J Exp Med 1999; 189: 767. 82 S. Manici,T. Sturniolo, M. A. Imro, J. Hammer, F. Sinigaglia, C. Noppen, G. Spagnoli, B. Mazzi, M. Bellone, P. Dellabona, M. P. Protti, J Exp Med 1999; 189: 871. 83 E. S. Schultz, B. Lethe, C. L. Cambiaso, J. Van Snick, P. Chaux, J. Corthals, C. Heirman, K. Thielemans, T. Boon, P. van der Bruggen, <strong>Cancer</strong> Res 2000; 60: 6272. 84 G. Zeng, C. E. Touloukian, X. Wang, N. P. Restifo, S. A. Rosenberg, R. F. Wang, J Immunol 2000; 165: 1153. 85 E. Jager, D. Jager, J. Karbach, Y. T. Chen, G. Ritter,Y. Nagata, S. Gnjatic, E. Stockert, M. Ar<strong>and</strong>, L. J. Old, A. Knuth, J Exp Med 2000; 191: 625. 86 G. Zeng, X. Wang, P. F. Robbins, S. A. Rosenberg, R. F. Wang, Proc Natl Acad Sci USA 2001; 98: 3964. 87 H. M. Zarour, J. M. Kirkwood, L. S. Kierstead,W. Herr,V. Brusic, C. L. Slingluff, Jr, J. Sidney, A. Sette, W. J. Storkus, Proc Natl Acad Sci USA 2000; 97: 400. 88 F. Crawford, H. Kozono, J. White, P. Marrack, J. Kappler, Immunity 1998; 8: 675. 89 I. Gutgemann, A. M. Fahrer, J. D. Altman, M. M. Davis,Y. H. Chien, Immunity 1998; 8: 667. 90 T. O. Cameron, J. R. Cochran, B.Yassine-Diab, R. P. Sekaly, L. J. Stern, J Immunol 2001; 166: 741. 91 B. L. Kotzin, M. T. Falta, F. Crawford, E. F. Rosloniec, J. Bill, P. Marrack, J. Kappler, Proc Natl Acad Sci USA 2000; 97: 291. 92 E. J. Novak, A. W. Liu, G. T. Nepom, W. W. Kwok, J Clin Invest 1999; 104: R63. References 93 W. W. Kwok, A. W. Liu, E. J. Novak, J. A. Gebe, R. A. Ettinger, G. T. Nepom, S. N. Reymond, D. M. Koelle, J Immunol 2000; 164: 4244. 94 M. L. Albert, J. C. Darnell, A. Bender, L. M. Francisco, N. Bhardwaj, R. B. Darnell, Nat Med 1998; 4: 1321. 95 S. A. Rosenberg, D. E. White, JImmunother Emphasis Tumor Immunol 1996; 19:81. 96 D. Rimoldi,V. Rubio-Godoy,V. Dutoit, D. Lienard, S. Salvi, P. Guillaume, D. Speiser, E. Stockert, G. Spagnoli, C. Servis, J. C. Cerottini, F. Lejeune, P. Romero, D. Valmori, J Immunol 2000; 165: 7253. 97 M. Ayyoub, S. Stevanovic, U. Sahin, P. Guillaume, C. Servis, D. Rimoldi, D. Valmori, P. Romero, J. C. Cerottini, M. Rammensee, M. Pfreundschuh, D. Speiser, F. Levy, J Immunol 2002; 168: 1717. 98 D. Valmori, J. F. Fonteneau, C. M. Lizana, N. Gervois, D. Lienard, D. Rimoldi,V. Jongeneel, F. Jotereau, J. C. Cerottini, P. Romero, J Immunol 1998; 160: 1750. 99 P. Chaux, R. Luiten, N. Demotte, V. Vantomme,V. Stroobant, C.Traversari,V. Russo, E. Schultz, G. R. Cornelis,T. Boon, P. van der Bruggen, J Immunol 1999; 163: 2928. 100 H. Kobayashi,T. Kokubo, K. Sato, S. Kimura, K. Asano, H. Takahashi, H. Iizuka, N. Miyokawa, M. Katagiri, <strong>Cancer</strong> Res 1998; 58: 296. 101 J. M. Corman, E. E. Sercarz, N. K. N<strong>and</strong>a, Clin Exp Immunol 1998; 114: 166. 102 R. Pieper, R. E. Christian, M. I. Gonzales, M. I. Nishimura, G. Gupta, R. E. Settlage, J. Shabanowitz, S. A. Rosenberg, D. F. Hunt, S. L.Topalian, J Exp Med 1999; 189: 757. 103 H. Hohn, H. Pilch, S. Gunzel, C. Neukirch, C. Hilmes, A. Kaufmann, B. Seliger, M. J. Maeurer, JImmunol 1999; 163: 5715. 104 E. M. Hiltbold, P. Ciborowski, O. J. Finn, <strong>Cancer</strong> Res 1998; 58: 5066. 105 D. Valmori,V. Dutoit, D. Lienard, F. Lejeune, D. Speiser, D. Rimoldi, V. Cerundolo, P. Y. Dietrich, J. C. Cerottini, P. Romero, J Immunol 2000; 165: 533. 55
Part 2 <strong>Immune</strong> Evasion <strong>and</strong> Suppression <strong>Cancer</strong> <strong>Immune</strong> Therapie: Current <strong>and</strong> Future Strategies <strong>Edited</strong> <strong>by</strong> G. <strong>Stuhler</strong> <strong>and</strong> P. <strong>Walden</strong> Copyright # 2002 Wiley-VCH Verlag GmbH & Co. KGaA ISBNs: 3-527-30441-X (Hardback); 3-527-60079-5 (Electronic)
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Cancer Immune Therapie: Current and
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Editors: Dr. Gernot Stuhler Univers
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VI Preface Recent years have seen a
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VIII Contents 2.5.3 Antigens Encode
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X Contents 6.4.2 Natural Killer (NK
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XII Contents 9.6 Loading DC with An
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XIV Contents 14.2.2.1 Cancer-specif
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List of Contributors Richard Bucala
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Color Plates Fig. 5.2 The MHC class
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Fig. 5.5 Different immune effector
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Fig. 5.17 Possible pathway for the
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Fig. 6.2 T lymphocytes in the tumor
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Index a acidic and basic fibroblast
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±, see also tumors cationic lipids
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e EBV see Epstein-Barr virus EDR se
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immature Mo-DCs 184 immune cells ±
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MHC class I antigen-processing mach
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±, onco- 209 ±, over-expressed ce
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TICD see tumor-induced cell death T
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Part 1 Tumor Antigenicity Cancer Im
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108 6 Immune Cells in the Tumor Mic
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110 6 Immune Cells in the Tumor Mic
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112 6 Immune Cells in the Tumor Mic
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114 6 Immune Cells in the Tumor Mic
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116 6 Immune Cells in the Tumor Mic
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118 6 Immune Cells in the Tumor Mic
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Tab. 7.1 Effects of tumor-derived m
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122 7 Immunosuppresive Factors in C
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124 7 Immunosuppresive Factors in C
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156 8 Interleukin-10 in Cancer Immu
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158 8 Interleukin-10 in Cancer Immu
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160 8 Interleukin-10 in Cancer Immu
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162 8 Interleukin-10 in Cancer Immu
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164 8 Interleukin-10 in Cancer Immu
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168 8 Interleukin-10 in Cancer Immu
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170 8 Interleukin-10 in Cancer Immu
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172 8 Interleukin-10 in Cancer Immu
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174 8 Interleukin-10 in Cancer Immu
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Part 3 Strategies for Cancer Immuno
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180 9 Dendritic Cells and Cancer: P
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184 9 Dendritic Cells and Cancer: P
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204 Cancer Immune Therapie: Current
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206 10 The Immune System in Cancer:
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208 10 The Immune System in Cancer:
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210 10 The Immune System in Cancer:
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212 10 The Immune System in Cancer:
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214 10 The Immune System in Cancer:
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216 10 The Immune System in Cancer:
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218 10 The Immune System in Cancer:
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220 10 The Immune System in Cancer:
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222 10 The Immune System in Cancer:
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224 10 The Immune System in Cancer:
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226 10 The Immune System in Cancer:
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228 10 The Immune System in Cancer:
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230 Cancer Immune Therapie: Current
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232 11 Hybrid Cell Vaccination for
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234 11 Hybrid Cell Vaccination for
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236 11 Hybrid Cell Vaccination for
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238 11 Hybrid Cell Vaccination for
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240 11 Hybrid Cell Vaccination for
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248 11 Hybrid Cell Vaccination for
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250 11 Hybrid Cell Vaccination for
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252 11 Hybrid Cell Vaccination for
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254 12 Principles and Strategies Em
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260 12 Principles and Strategies Em
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264 12 Principles and Strategies Em
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266 12 Principles and Strategies Em
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268 Cancer Immune Therapie: Current
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288 14 The T-Body Approach: Towards
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294 14 The T-Body Approach: Towards
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300 15 Bone Marrow Transplantation
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302 15 Bone Marrow Transplantation
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348 17 Immunotoxins and Recombinant
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350 17 Immunotoxins and Recombinant
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378 17 Immunotoxins and Recombinant
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380 Cancer Immune Therapie: Current
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382 Glossary tion to the variable d
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384 Glossary suppressor gene produc
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386 Glossary press the proper recep
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388 Glossary gp96 See Chaperone. Gr
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390 Glossary cytes and addressing l
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392 Glossary T bodies are being tes