Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...

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Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic Tcell responses to soluble proteins. Eur J Immunol 2000; 30: 3591± 3597. 118 Vabulas, R. M., Pircher, H., Lipford, G. B., Hacker, H. and Wagner, H. CpG-DNA activates in vivo T cell epitope presenting dendritic cells to trigger protective antiviral cytotoxic T cell responses. J Immunol 2000; 164: 2372± 2378. 119 Chu, R. S.,Targoni, O. S., Krieg, A. M., Lehmann, P. V. and Harding, C. V. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med 1997; 186: 1623± 1631. 120 Roman, M., Martin-Orozco, E., Goodman, J. S., et al. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants [see Comments]. Nat Med 1997; 3: 849±854. 121 Wild, J., Grusby, M. J., Schirmbeck, R. and Reimann, J. Priming MHC-I-restricted cytotoxic T lymphocyte responses to exogenous hepatitis B surface antigen is CD4 + T cell dependent. J Immunol 1999; 163: 1880±1887. 122 Davis, H. L.,Weeratna, R., Waldschmidt, T. J., et al. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen [published erratum appears in J Immunol 1999; 162(5): 3103]. J Immunol 1998; 160: 870±876. 123 Weiner, G. J., Liu, H. M., Wooldridge, J. E., Dahle, C. E. and Krieg, A. M. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc Natl Acad Sci USA 1997; 94: 10833±10837. 124 Sun, S., Kishimoto, H. and Sprent, J. DNA as an adjuvant: capacity of insect DNA and synthetic oligodeoxynucleotides to augment T cell responses to specific antigen. J Exp Med 1998; 187: 1145±1150. 125 Kim, S. K., Ragupathi, G., Musselli, C., et al. Comparison of the effect of different immunological adjuvants on the References antibody and T-cell response to immunization with MUC1±KLH and GD3±KLH conjugate cancer vaccines. Vaccine 1999; 18: 597±603. 126 Liu, H. M., Newbrough, S. E., Bhatia, S. K., et al. Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor. Blood 1998; 92: 3730±3736. 127 Davila, E. and Celis, E. Repeated administration of cytosine-phosphorothiolated guanine-containing oligonucleotides together with peptide/protein immunization results in enhanced CTL responses with anti-tumor activity. JImmunol 2000; 165: 539±547. 128 Egeter, O., Mocikat, R., Ghoreschi, K., Dieckmann, A. and Rocken, M. Eradication of disseminated lymphomas with CpG-DNA activated T helper type 1 cells from nontransgenic mice. Cancer Res 2000; 60: 1515±1520. 129 Brunner, C., Seiderer, J., Schlamp, A., et al. Enhanced dendritic cell maturation by TNF-a or cytidine-phosphate-guanosine DNA drives Tcell activation in vitro and therapeutic anti-tumor immune responses in vivo. J Immunol 2000; 165: 6278±6286. 130 Wooldridge, J. E., Ballas, Z., Krieg, A. M. and Weiner, G. J. Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma. Blood 1997; 89: 2994± 2998. 131 Warren, T. L., Dahle, C. E. and Weiner, G. J. CpG oligodeoxynucleotides enhance monoclonal antibody therapy of a murine lymphoma. Clin Lymphoma 2000; 1: 57±61. 132 Jahrsdorfer, B., Hartmann, G., Racila, E., et al. CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens. J Leuk Biol 2001; 69: 81±88. 133 Decker, T., Schneller, F., Sparwasser, T., et al. Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lym- 285
286 13 Applications of CpG Motifs from Bacterial DNA in Cancer Immunotherapy phocytic leukemia B cells. Blood 2000; 95: 999±1006. 134 Decker, T., Schneller, F., Kronschnabl, M., et al. Immunostimulatory CpG-oligonucleotides induce functional high affinity IL-2 receptors on B-CLL cells: costimulation with IL-2 results in a highly immunogenic phenotype. Exp Hematol 2000; 28: 558±568.
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Cancer Immune Therapie: Current and
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Editors: Dr. Gernot Stuhler Univers
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VI Preface Recent years have seen a
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VIII Contents 2.5.3 Antigens Encode
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X Contents 6.4.2 Natural Killer (NK
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XII Contents 9.6 Loading DC with An
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XIV Contents 14.2.2.1 Cancer-specif
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List of Contributors Richard Bucala
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Color Plates Fig. 5.2 The MHC class
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Fig. 5.5 Different immune effector
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Fig. 5.17 Possible pathway for the
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Fig. 6.2 T lymphocytes in the tumor
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Index a acidic and basic fibroblast
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±, see also tumors cationic lipids
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e EBV see Epstein-Barr virus EDR se
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immature Mo-DCs 184 immune cells ±
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MHC class I antigen-processing mach
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±, onco- 209 ±, over-expressed ce
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TICD see tumor-induced cell death T
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Part 1 Tumor Antigenicity Cancer Im
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4 1 Search for Universal Tumor-Asso
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10 1 Search for Universal Tumor-Ass
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18 2 Serological Determinants On Tu
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30 Cancer Immune Therapie: Current
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32 3 Processing and Presentation of
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42 4 T Cells In Tumor Immunity cult
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44 4 T Cells In Tumor Immunity cell
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46 4 T Cells In Tumor Immunity to T
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48 4 T Cells In Tumor Immunity Alth
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50 4 T Cells In Tumor Immunity Tab.
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52 4 T Cells In Tumor Immunity rest
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54 4 T Cells In Tumor Immunity 53 T
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Part 2 Immune Evasion and Suppressi
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60 5 Major Histocompatibility Compl
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68 Tab. 5.1 HLA class I loss attrib
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96 6 Immune Cells in the Tumor Micr
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98 6 Immune Cells in the Tumor Micr
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100 6 Immune Cells in the Tumor Mic
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Tab. 7.1 Effects of tumor-derived m
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122 7 Immunosuppresive Factors in C
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156 8 Interleukin-10 in Cancer Immu
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Part 3 Strategies for Cancer Immuno
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180 9 Dendritic Cells and Cancer: P
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206 10 The Immune System in Cancer:
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232 11 Hybrid Cell Vaccination for
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Page 303 and 304: 270 13 Applications of CpG Motifs f
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Page 345 and 346: 312 16 Immunocytokines: Versatile M
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336 16 Immunocytokines: Versatile M
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348 17 Immunotoxins and Recombinant
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382 Glossary tion to the variable d
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384 Glossary suppressor gene produc
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386 Glossary press the proper recep
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388 Glossary gp96 See Chaperone. Gr
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390 Glossary cytes and addressing l
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392 Glossary T bodies are being tes
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