Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...

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400 Index graft-versus-tumor (GvT) effect 299, 301 granules, Birbeck 180 granulocyte macrophage colony stimulating factor (GM-CSF) ±, dendritic cells 184 ±, effects of IL-10 165 granulocytes, FasL 112f. growth factor ±, fibroblast see fibroblast growth factor ±, insulin-like see insulin-like growth factor ±, nerve see nerve growth factor ±, transforming see transforming growth factor ±, vascular endothelial see vascular endothelial growth factor GvH see graft-versus-host GvHD see graft-versus-host disease GvL see graft-versus-leukemia GvT see graft-versus-tumor h hairy cell leukemia (HCL) 362 haplo-cell transplantation 306 HCL see hairy cell leukemia HCT see hematopoietic cell transplantation HCV see hybrid cell vaccination heat shock proteins (HSP) 253±267 ±, cancer immunotherapy 256±263 ±, dendritic cells 181 ±, HCV 240 ±, tumor cell killing 218 helper epitopes, dendritic cells 187, 195 helper T cells 233, 324 ±, HCV 236f. ±, immunotoxins 367 hematopoietic cell transplantation (HCT) seebone marrow transplantation hepatotoxicity 361 Heregulin see Neuregulin differentiation factor Herpes Simplex virus (HSV) 304ff. high-affinity bindings, immunotoxins 363 high-affinity cytokine receptors 234 high-affinity responses 195 HIV, T-body approach 293 HLA see human leucocyte antigen HLA-C locus expression 78 HLA class II restricted tumor associated antigens 49f. HLA-G expression 85±89 HLA/peptide tetramer responses ±, dendritic cells 188, 195 Hodgkin lymphomas, effects of IL-10 163 HOM-MEL-40 antigen 21 HOM-TES-14 antigen 24 homologs, IL-10 157 hot spots, DNA 366 HSP see heat shock proteins HSP/peptide covalent complex 259f. HSP/peptide fusion proteins 260 HSP/peptide non-covalent complex 259 HSV see Herpes Simplex virus HSV-tk see thymidine kinases of Herpes Simplex virus hTERT see human telomerase reverse transcriptase huKS1/4-IL2 immunocytokine 316f., 319, 323±328, 340f. human cancer, dendritic cells 182f. human leucocyte antigen (HLA) 49f., 60±76, 215 ±, immunotoxins 365 ±, MHC class I expression 85±89 ±, MHC class II expression 82 ±, mutations 75 human telomerase reverse transcriptase (hTERT) 8±12 human/mouse antiganglioside GD 2 antibody (ch14.18) 312ff., 337 hybrid cell vaccination (HCV) 230±252 ±, dendritic cells 187 hybrid proteasomes 33 hybridoma technology 364 hyperthermia, modulation of HSPs 261 i ICAM see intercellular adhesion molecule Id see idiotype idiotype (Id), antigen 276 IFA see imcomplete Freund's adjuvant IFN see interferon IGF see insulin-like growth factor IgG1 <strong>and</strong> IgG2 isotypes, bacterial immunotherapy 276 IL-2 see interleukin-2 IL-10 see interleukin-10 ±, immunosuppressive factors 120 IL-10 expression 155f. ±, in cancer patients 161±164 IL-10 homologs 157 IL-10 presence, in cancer patients 163 IL-10 production, selectivity 162f. IL-10 receptor (IL-10R) 155ff. IL-12, immunosuppressive factors 122 ILT see immunoglogulin-like transcript imcomplete Freund's adjuvant (IFA) 234 immature DCs 220
immature Mo-DCs 184 immune cells ±, effects of IL-10 158, 160f. ±, tumor microenvironment 95±118 immune effector mechanisms 65f. immune escape, IL-10 therapy 167 immune responses ±, evolution 77 ±, recombinant immunotoxins 367f. ±, see also immunoresponses immune selection 96, 208 immune surveillance 230 immune system ±, <strong>and</strong> tumor progression 95ff. ±, in cancer 204±229 immune tolerance 363 immuno-proteasomes 31±37, 60 immunobiological tolerance 206f. immunocytokines, overview 311±346 immunoediting 206 immunogenicity, of tumor cells 234 immunoglogulin-like transcript (ILT) molecules 180 immunological ignorance 12 immunological tolerance 12 immunology ±, cancer 177±379 ±, reverse see epitope deduction immunome, cancer 24f. immunoresponses ±, inhibition 108f. ±, MHC class I alterations 76±79 ±, monitoring 194f. ±, see also immune responses immunosuppression ±, IL-10 155 ±, tumor-induced 107 immunosuppressive factors 119±154 immunosurveillance 40, 65f., 96 ±, cancer 204 ±, IL-10 155 ±, interferon (IFN)-g 83ff. immunotherapy, adoptive 301 immunotoxins 347±379 in vitro models, of tumors 218±221 in vivo models, of tumors 218±221 indiviualized immunotherapy 256 inflammation, immune responses 211 innate immunity, HSPs 253 insulin-like growth factor (IGF)-1 350 integrin a vb 3 341 intercellular adhesion molecule (ICAM) 320 interferon (IFN)-g 31, 33ff., 60 ±, bacterial immunotherapy 273f. ±, HLA-G expression 86f. ±, hybrid cell vaccination (HCV) 234 ±, immunocytokines 322ff., 335f., 339 ±, immunosurveillance 83ff. ±, MHC class I antigens 69±72, 78ff. ±, MHC class II antigens 81ff. ±, NK cells 102ff. ±, T cells 100 interleukin-2 (IL-2) ±, hybrid cell vaccination (HCV) 234 ±, immunocytokines 313f., 327±341 ±, immunotoxins 347, 354, 361f. ±, T cells 100 ±, T-body approach 293ff. ±, see also cytokines interleukin-10 (IL-10) ±, immunocytokines 339 ±, immunosuppressive factors 125±129 ±, in cancer immunity 155±175 ±, T cells 100 ±, see also cytokines intracellular tyrosine activation motifs (ITAMs) 289 IRF transcription factor 83f. isotypes, IgG 276 ITAMs see intracellular tyrosine activation motifs j JAK see janus tyrosine kinase janus tyrosine kinase (JAK) 83ff. ±, IL-10 157 ±, immunosuppressive factors 122f. Index k Kaplan-Meier survival curves 107, 331 KARs see killer activating receptors KDEL, gp96 262 keyhole limpet hemocyanin (KLH) 191, 276 killer activating receptors (KARs) 102 killer inhibitory receptors (KIRs) 63, 88, 102 KIRs see killer inhibitory receptors KLH see keyhole limpet hemocyanin KSA see Ep-CAM/KS antigen l lactate dehydrogenase, antigen 20 Lagerhans cells (LCs) 179 LAK see lymphokine-activated killer LAP see latency-associated peptide latency-associated peptide (LAP) 119 latent TGF-b binding protein 119ff. LCs see Lagerhans cells 401
Page 1 and 2: Cancer Immune Therapie: Current and
Page 3 and 4: Editors: Dr. Gernot Stuhler Univers
Page 5 and 6: VI Preface Recent years have seen a
Page 7 and 8: VIII Contents 2.5.3 Antigens Encode
Page 9 and 10: X Contents 6.4.2 Natural Killer (NK
Page 11 and 12: XII Contents 9.6 Loading DC with An
Page 13 and 14: XIV Contents 14.2.2.1 Cancer-specif
Page 15 and 16: List of Contributors Richard Bucala
Page 17 and 18: Color Plates Fig. 5.2 The MHC class
Page 19 and 20: Fig. 5.5 Different immune effector
Page 21 and 22: Fig. 5.17 Possible pathway for the
Page 23 and 24: Fig. 6.2 T lymphocytes in the tumor
Page 25 and 26: Index a acidic and basic fibroblast
Page 27 and 28: ±, see also tumors cationic lipids
Page 29: e EBV see Epstein-Barr virus EDR se
Page 33 and 34: MHC class I antigen-processing mach
Page 35 and 36: ±, onco- 209 ±, over-expressed ce
Page 37 and 38: TICD see tumor-induced cell death T
Page 39 and 40: Part 1 Tumor Antigenicity Cancer Im
Page 41 and 42: 4 1 Search for Universal Tumor-Asso
Page 47 and 48: 10 1 Search for Universal Tumor-Ass
Page 55 and 56: 18 2 Serological Determinants On Tu
Page 67 and 68: 30 Cancer Immune Therapie: Current
Page 69 and 70: 32 3 Processing and Presentation of
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Page 79 and 80: 42 4 T Cells In Tumor Immunity cult
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44 4 T Cells In Tumor Immunity cell
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46 4 T Cells In Tumor Immunity to T
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48 4 T Cells In Tumor Immunity Alth
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50 4 T Cells In Tumor Immunity Tab.
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52 4 T Cells In Tumor Immunity rest
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54 4 T Cells In Tumor Immunity 53 T
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Part 2 Immune Evasion and Suppressi
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60 5 Major Histocompatibility Compl
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68 Tab. 5.1 HLA class I loss attrib
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96 6 Immune Cells in the Tumor Micr
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98 6 Immune Cells in the Tumor Micr
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100 6 Immune Cells in the Tumor Mic
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Tab. 7.1 Effects of tumor-derived m
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122 7 Immunosuppresive Factors in C
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156 8 Interleukin-10 in Cancer Immu
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Part 3 Strategies for Cancer Immuno
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180 9 Dendritic Cells and Cancer: P
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204 Cancer Immune Therapie: Current
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206 10 The Immune System in Cancer:
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232 11 Hybrid Cell Vaccination for
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254 12 Principles and Strategies Em
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270 13 Applications of CpG Motifs f
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288 14 The T-Body Approach: Towards
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300 15 Bone Marrow Transplantation
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312 16 Immunocytokines: Versatile M
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348 17 Immunotoxins and Recombinant
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382 Glossary tion to the variable d
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384 Glossary suppressor gene produc
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386 Glossary press the proper recep
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388 Glossary gp96 See Chaperone. Gr
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390 Glossary cytes and addressing l
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392 Glossary T bodies are being tes
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