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Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...

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372 17 Immunotoxins <strong>and</strong> Recombinant Immunotoxins in <strong>Cancer</strong> <strong>Therapy</strong><br />

strom resolution. Proc Natl Acad Sci<br />

USA 83: 1320±4.<br />

56 Hwang J, FitzGerald DJ, Adhya S,<br />

Pastan I (1987) Functional domains of<br />

Pseudomonas exotoxin identified <strong>by</strong> deletion<br />

analysis of the gene expressed in<br />

E. coli. Cell 48: 129±36.<br />

57 Kounnas MZ, Morris RE, Thompson<br />

MR, FitzGerald DJ, Strickl<strong>and</strong><br />

DK, Saelinger CB (1992) The a 2macroglobulin<br />

receptor/low density lipoprotein<br />

receptor-related protein binds<br />

<strong>and</strong> internalizes Pseudomonas exotoxin<br />

A. J Biol Chem 267: 12420±3.<br />

58 Siegall CB, Chaudhary VK, Fitz-<br />

Gerald DJ, Pastan I (1989) Functional<br />

analysis of domains II, Ib, <strong>and</strong> III of<br />

Pseudomonas exotoxin. J Biol Chem 264:<br />

14256±61.<br />

59 Jinno Y, Ogata M, Chaudhary VK,<br />

Willingham MC, Adhya S, FitzGerald<br />

D, Pastan I (1989) Domain II mutants<br />

of Pseudomonas exotoxin deficient<br />

in translocation. J Biol Chem 264:<br />

15953±9.<br />

60 Idziorek T, FitzGerald D, Pastan I<br />

(1990) Low pH-induced changes in<br />

Pseudomonas exotoxin <strong>and</strong> its domains:<br />

increased binding of Triton X-114. Infect<br />

Immun 58: 1415±20.<br />

61 Jiang JX, London E (1990) Involvement<br />

of denaturation-like changes in<br />

Pseudomonas exotoxin a hydrophobicity<br />

<strong>and</strong> membrane penetration determined<br />

<strong>by</strong> characterization of pH <strong>and</strong> thermal<br />

transitions. Roles of two distinct conformationally<br />

altered states. J Biol Chem<br />

265: 8636±41.<br />

62 Ogata M, Pastan I, FitzGerald D<br />

(1991) Analysis of Pseudomonas exotoxin<br />

activation <strong>and</strong> conformational<br />

changes <strong>by</strong> using monoclonal antibodies<br />

as probes. Infect Immun 59: 407±<br />

14.<br />

63 Carroll SF, Collier RJ (1988) Amino<br />

acid sequence homology between the<br />

enzymic domains of diphtheria toxin<br />

<strong>and</strong> Pseudomonas aeruginosa exotoxin A.<br />

Mol Microbiol 2: 293±6.<br />

64 Br<strong>and</strong>huber BJ, Allured VS, Falbel<br />

TG, McKay DB (1988) Mapping the<br />

enzymatic active site of Pseudomonas<br />

aeruginosa exotoxin A. Proteins 1988; 3:<br />

146±54.<br />

65 Carroll SF, Collier RJ (1987) Active<br />

site of Pseudomonas aeruginosa exotoxin<br />

A. Glutamic acid 553 is photolabeled <strong>by</strong><br />

NAD <strong>and</strong> shows functional homology<br />

with glutamic acid 148 of diphtheria<br />

toxin. J Biol Chem 262: 8707±11.<br />

66 Wozniak DJ, Hsu LY, Galloway DR<br />

(1988) His-426 of the Pseudomonas aeruginosa<br />

exotoxin A is required for ADPribosylation<br />

of elongation factor II. Proc<br />

Natl Acad Sci USA 85: 8880±4.<br />

67 Jinno Y, Chaudhary VK, Kondo T,<br />

Adhya S, FitzGerald DJ, Pastan I<br />

(1988) Mutational analysis of domain I<br />

of Pseudomonas exotoxin. Mutations in<br />

domain I of Pseudomonas exotoxin<br />

which reduce cell binding <strong>and</strong> animal<br />

toxicity. J Biol Chem 263: 13203±7.<br />

68 Kondo T, FitzGerald D, Chaudhary<br />

VK, Adhya S, Pastan I (1988) Activity<br />

of immunotoxins constructed<br />

with modified Pseudomonas exotoxin A<br />

lacking the cell recognition domain.<br />

J Biol Chem 263: 9470±5.<br />

69 Batra JK, Jinno Y, Chaudhary VK,<br />

et al. (1989) Antitumor activity in mice<br />

of an immunotoxin made with antitransferrin<br />

receptor <strong>and</strong> a recombinant<br />

form of Pseudomonas exotoxin. Proc<br />

Natl Acad Sci USA 86: 8545±9.<br />

70 Chaudhary VK, Jinno Y, Fitz-<br />

Gerald D, Pastan I (1990) Pseudomonas<br />

exotoxin contains a specific sequence<br />

at the carboxyl terminus that is<br />

required for cytotoxicity. Proc Natl Acad<br />

Sci USA 87: 308±12.<br />

71 Seetharam S, Chaudhary VK, Fitz-<br />

Gerald D, Pastan I (1991) Increased<br />

cytotoxic activity of Pseudomonas exotoxin<br />

<strong>and</strong> two chimeric toxins ending in<br />

KDEL. J Biol Chem 266: 17376±81.<br />

72 Raag R,Whitlow M (1995) Singlechain<br />

Fvs. FASEBJ 9: 73±80.<br />

73 Winter G, Milstein C (1991) Manmade<br />

antibodies. Nature 349: 293±9.<br />

74 Reiter Y, Brinkmann U, Lee B, Pastan<br />

I (1996) Engineering antibody Fv<br />

fragments for cancer detection <strong>and</strong><br />

therapy: disulfide-stabilized Fv fragments.<br />

Nat Biotechnol 14: 1239±45.<br />

75 Choe M,Webber KO, Pastan I (1994)<br />

B3(Fab)±PE38M: a recombinant immunotoxin<br />

in which a mutant form of<br />

Pseudomonas exotoxin is fused to the

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