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Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...

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144 7 Immunosuppresive Factors in <strong>Cancer</strong><br />

Interleukin-10 down-regulates MHC<br />

class II ab peptide complexes at the<br />

plasma membrane of monocytes <strong>by</strong> affecting<br />

arrival <strong>and</strong> recycling. Immunity<br />

7: 861.<br />

131 Ding, L., P. S. Linsley, L. Y. Huang,<br />

R. N. Germain <strong>and</strong> E. M. Shevach.<br />

1993. IL-10 inhibits macrophage costimulatory<br />

activity <strong>by</strong> selectively inhibiting<br />

the up-regulation of B7 expression.<br />

J. Immunol. 151: 1224.<br />

132 Willems, F., A. Marchant, J. P. Delville,<br />

C. Gerard, A. Delvaux, T. Velu,<br />

M. de Boer <strong>and</strong> M. Goldman. 1994.<br />

Interleukin-10 inhibits B7 <strong>and</strong> intercellular<br />

adhesion molecule-1 expression<br />

on human monocytes. Eur. J. Immunol.<br />

24: 1007.<br />

133 Walker, T. M., C. J. Burger <strong>and</strong><br />

K. D. Elgert. 1994. Tumor growth alters<br />

T cell <strong>and</strong> macrophage production<br />

of <strong>and</strong> responsiveness to granulocytemacrophage<br />

colony-stimulating factor:<br />

partial dysregulation through interleukin-10.<br />

Cell Immunol. 154: 342.<br />

134 de Waal Malefyt, R., H. Yssel <strong>and</strong><br />

J. E. de Vries. 1993. Direct effects of IL-<br />

10 on subsets of human CD4 + T cell<br />

clones <strong>and</strong> resting T cells. Specific inhibition<br />

of IL-2 production <strong>and</strong> proliferation.<br />

J. Immunol. 150: 4754.<br />

135 Taga, K. <strong>and</strong> G. Tosato. 1992. IL-10 inhibits<br />

human T cell proliferation <strong>and</strong><br />

IL-2 production. J. Immunol. 148: 1143.<br />

136 Barth, R. J., Jr, M. A. Coppola <strong>and</strong><br />

W. R. Green. 1996. In vivo effects of locally<br />

secreted IL-10 on the murine antitumor<br />

immune response. Ann. Surg.<br />

Oncol. 3: 381.<br />

137 Steinbrink, K., H. Jonuleit, G. Muller,<br />

G. Schuler, J. Knop <strong>and</strong> A. H. Enk.<br />

1999. Interleukin-10-treated human<br />

dendritic cells induce a melanoma-antigen-specific<br />

anergy in CD8(+) T cells resulting<br />

in a failure to lyse tumor cells.<br />

Blood 93: 1634.<br />

138 Steinbrink, K., M. Wolfl, H. Jonuleit,<br />

J. Knop <strong>and</strong> A. H. Enk. 1997. Induction<br />

of tolerance <strong>by</strong> IL-10-treated<br />

dendritic cells. J. Immunol. 159: 4772.<br />

139 Groux, H., M. Bigler, J. E. de Vries<br />

<strong>and</strong> M. G. Roncarolo. 1996. Interleukin-10<br />

induces a long-term antigen-spe-<br />

cific anergic state in human CD4 + T<br />

cells. J. Exp. Med. 184: 19.<br />

140 Chen, M. L., F. H. Wang, P. K. Lee<br />

<strong>and</strong> C. M. Lin. 2001. Interleukin-10-induced<br />

T cell unresponsiveness can be<br />

reversed <strong>by</strong> dendritic cell stimulation.<br />

Immunol. Lett. 75: 91.<br />

141 Bejarano, M. T., R. de Waal Malefyt,<br />

J. S. Abrams, M. Bigler, R. Bacchetta,<br />

J. E. de Vries <strong>and</strong> M. G. Roncarolo.<br />

1992. Interleukin 10 inhibits allogeneic<br />

proliferative <strong>and</strong> cytotoxic T cell responses<br />

generated in primary mixed<br />

lymphocyte cultures. Int. Immunol. 4:<br />

1389.<br />

142 Hsieh, C. L., D. S. Chen <strong>and</strong><br />

L. H. Hwang. 2000. Tumor-induced immunosuppression:<br />

a barrier to immunotherapy<br />

of large tumors <strong>by</strong> cytokinesecreting<br />

tumor vaccine. Hum. Gene<br />

Ther. 11: 681.<br />

143 Fitzpatrick, L., A. P. Makrigiannis,<br />

M. Kaiser <strong>and</strong> D. W. Hoskin. 1996.<br />

Anti-CD3-activated killer T cells: interferon-g<br />

<strong>and</strong> interleukin-10 cross-regulate<br />

granzyme B expression <strong>and</strong> the induction<br />

of major histocompatibility<br />

complex-unrestricted cytotoxicity. J. Interferon<br />

Cytokine Res. 16: 537.<br />

144 Wang, L., E. Goillot <strong>and</strong> R. I. Tepper.<br />

1994. IL-10 inhibits alloreactive cytotoxic<br />

T lymphocyte generation in vivo.<br />

Cell. Immunol. 159: 152.<br />

145 Sharma, S., M. Stolina,Y. Lin,<br />

B. Gardner, P. W. Miller, M. Kronenberg<br />

<strong>and</strong> S. M. Dubinett. 1999. T cellderived<br />

IL-10 promotes lung cancer<br />

growth <strong>by</strong> suppressing both T cell <strong>and</strong><br />

APC function. J. Immunol. 163: 5020.<br />

146 Huang, S., S. E. Ullrich <strong>and</strong> M. Bar-<br />

Eli. 1999. Regulation of tumor growth<br />

<strong>and</strong> metastasis <strong>by</strong> interleukin-10: the<br />

melanoma experience. J. Interferon Cytokine<br />

Res. 19: 697.<br />

147 Zheng, L. M., D. M. Ojcius, F. Garaud,<br />

C. Roth, E. Maxwell, Z. Li,<br />

H. Rong, J. Chen, X. Y. Wang, J. J. Catino<br />

<strong>and</strong> I. King. 1996. Interleukin-10<br />

inhibits tumor metastasis through an<br />

NK cell-dependent mechanism. J. Exp.<br />

Med. 184: 579.<br />

148 Jinquan, T., C. G. Larsen, B. Gesser,<br />

K. Matsushima <strong>and</strong> K. Thestrup-Pedersen.<br />

1993. Human IL-10 is a che-

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