Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...

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Tab. 9.1 Reports on the use of DC for cancer immunotherapy 9.8 Phase I/II Clinical Trials Type of cancer Antigen Center DC type Route of Number of Response reported Reference immuni- individuals zation immunized NHL idiotype Standford Im Mo i.v. > s.c. 4 1 CR, 1 PR; antigen-specific lymphocyte proliferation Multiple myeloma Multiple myeloma Multiple myeloma (follow-up) Multiple myeloma Chronic myeloid leukemia idiotype protein idiotype protein + KLH idiotype protein + KLH idiotype protein + KLH leukemic DC (Ph1 + ) Melanoma Mart-1, gp100 peptides Melanoma Melan-A, gp100 Melanoma Melan-A, tyrosinase, MAGE3 + influenza MP Melanoma lysate/peptide mix + KLH Melanoma MAGE A1/ A3 peptide Melanoma tyrosinase, gp100 peptides Melanoma Melan-A or MAGE-1 tyrosinase 189 Cardiff Im Mo i.v. 1 antigen-specific lymphocyte proliferation response, antibodies 137 Stanford blood i.v. 12 11/12 KLH, 2/12 idiotype-specific lymphocyte proliferation (CR) 139 Stanford blood i.v. 26 24/26 KLH, 4/26 idiotype-specific lymphocyte proliferation (CR) 140 Cardiff Im Mo i.v. 6 Increase CTL proliferation in 3/6; antibodies; idiotype proliferation; IFN-g ELISA 174 Ninomaru Ma Mo i.v. 1 Ph1-specific CTL 161 Bethesda Im Mo i.v. 10 increased CTL 1/5, 1 PR; metastasis regression 76 Freiburg CD34 + i.v. 14 peptide DTH, met regression, vitiligo 89 Dallas CD34 + i.d. 18 antigen-specific ELISPOT 16/18; met regression; delayed progression 91 Zçrich Im Mo i.n. 16 DTH to peptide and KLH, 2 CR, 3 PR, met regression Brussels Im Mo i.v. > s.c. 24 increase in peptidespecific CTL 14/24 Los Angeles Im Mo i.v. 16 1 CR, 2 SD, 5/16 IFN-g ELISA response Mainz Im Mo versus Ma Mo i.n. 11 3 PR, 2 SD of 8 evaluable 5/7 CTL Ma Mo; 1/7 CTL Im Mo 106 132 142 143 144
190 9 Dendritic Cells and Cancer: Prospects for Cancer Vaccination Tab. 9.1 (continued) Type of cancer Antigen Center DC type Route of Number of Response reported Reference immuni- individuals zation immunized Melanoma MAGE-3A1, HLA-A1 peptide Melanoma MAGE-3A1, HLA-A2 peptide Erlangen Ma Mo s.c., i.d. > i.v. Erlangen Ma Mo s.c., i.d. > i.v. 11 Peptide-specific CTL 6/11, metastasis regression 6/11 8 peptide-specific CTL 8/8 Melanoma tumor/allo Berlin Activated s.c. 16 1 CR, 1 PR, 5 SD 178 peripheral peripheral blood blood mononuclear mononuclear cell hybrid cells Breast/ovarian Her2/neu, MUC-1 peptides Tçbingen Ma Mo s.c. 10 5/10 CTL 159 Breast tumor lysate Osaka Mo i.n. 1 metastasis regression 160 Prostate fusion protein GM- CSF + PAP Prostate PSMA P1 and P2 peptides Prostate PMSA P1 and P2 peptides Prostate (follow-up) PMSA P1 and P2 peptides Prostate fusion protein GM- CSF + PAP Renal cell carcinoma Renal cell carcinoma tumor/allo DC hybrid cell lysate + KLH Seattle blood i.v. 31 lymphocyte proliferation to GM-CSF Seattle Im Mo i.v. 51 and PAP 7 PR, peptidespecific CTL Seattle Im Mo i.v. 37 1 CR, 10 PR 149 Seattle Im Mo i.v. 37 DTH and cytokine production relates to clinical response Rochester blood i.v. 13 Peptide-specific lymphocyte proliferation to T antibody PAP in 20/31 (delayed disease pro- Gættingen Ma Mo i.v. 17 gression) 4 CR, metastasis regression, 1 mass reduction >0% 117 Innsbruck Ma Mo i.v. 4 1 PR; KLH IFN-g responses 145 176 177 72 148 151 157
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Cancer Immune Therapie: Current and
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Editors: Dr. Gernot Stuhler Univers
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VI Preface Recent years have seen a
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VIII Contents 2.5.3 Antigens Encode
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X Contents 6.4.2 Natural Killer (NK
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XII Contents 9.6 Loading DC with An
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XIV Contents 14.2.2.1 Cancer-specif
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List of Contributors Richard Bucala
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Color Plates Fig. 5.2 The MHC class
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Fig. 5.5 Different immune effector
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Fig. 5.17 Possible pathway for the
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Fig. 6.2 T lymphocytes in the tumor
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Index a acidic and basic fibroblast
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±, see also tumors cationic lipids
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e EBV see Epstein-Barr virus EDR se
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immature Mo-DCs 184 immune cells ±
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MHC class I antigen-processing mach
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±, onco- 209 ±, over-expressed ce
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TICD see tumor-induced cell death T
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Part 1 Tumor Antigenicity Cancer Im
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4 1 Search for Universal Tumor-Asso
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10 1 Search for Universal Tumor-Ass
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18 2 Serological Determinants On Tu
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30 Cancer Immune Therapie: Current
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32 3 Processing and Presentation of
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42 4 T Cells In Tumor Immunity cult
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44 4 T Cells In Tumor Immunity cell
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46 4 T Cells In Tumor Immunity to T
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48 4 T Cells In Tumor Immunity Alth
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50 4 T Cells In Tumor Immunity Tab.
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52 4 T Cells In Tumor Immunity rest
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54 4 T Cells In Tumor Immunity 53 T
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Part 2 Immune Evasion and Suppressi
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60 5 Major Histocompatibility Compl
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68 Tab. 5.1 HLA class I loss attrib
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96 6 Immune Cells in the Tumor Micr
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98 6 Immune Cells in the Tumor Micr
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100 6 Immune Cells in the Tumor Mic
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Tab. 7.1 Effects of tumor-derived m
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122 7 Immunosuppresive Factors in C
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Page 171 and 172: 136 7 Immunosuppresive Factors in C
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Page 239 and 240: 206 10 The Immune System in Cancer:
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240 11 Hybrid Cell Vaccination for
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254 12 Principles and Strategies Em
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270 13 Applications of CpG Motifs f
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288 14 The T-Body Approach: Towards
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300 15 Bone Marrow Transplantation
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312 16 Immunocytokines: Versatile M
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348 17 Immunotoxins and Recombinant
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382 Glossary tion to the variable d
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384 Glossary suppressor gene produc
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386 Glossary press the proper recep
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388 Glossary gp96 See Chaperone. Gr
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390 Glossary cytes and addressing l
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392 Glossary T bodies are being tes
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