Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...
Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...
Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...
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±, onco- 209<br />
±, over-expressed cellular 231<br />
±, pokeweed antiviral protein 352<br />
±, Smad 121<br />
PRR see pattern recognition receptors<br />
PS see phosphorothioate<br />
PSA see prostate-specific antigen<br />
pseudomonas exotoxin (PE) 350±362, 367f.<br />
PSMA see prostate-specific membrane antigen<br />
PTKs see protein tyrosine kinases<br />
pw-CEA, immunocytokines 320, 325f.<br />
r<br />
radioimmunoconjugates, CEA-specific 319<br />
radiotherapy 299<br />
RCC see renal cell cancers<br />
reactive oxygen metabolites (ROM) 107f., 113<br />
receptors<br />
±, CpG motif 271f.<br />
±, epidermal growth factor 347<br />
±, Fc 277<br />
±,Fcg see Fcg receptors<br />
±, for the nerve growth factor 304f.<br />
±, IL-10 155ff.<br />
±, killer activating see killer activating<br />
receptors<br />
±, killer inhibitory see killer inhibitory<br />
receptors<br />
±, pattern recognition 271f.<br />
±, serine-thronine kinase 121<br />
±, T cell 210f.<br />
±, toll-like 180<br />
±, TRAIL-TRAIL see TRAIL-TRAIL receptor<br />
pathway<br />
±, transferrin 361<br />
recombinant antibody-cytokine fusion<br />
proteins 311f.<br />
recombinant antibody fragments, immunotoxins<br />
354±357<br />
recombinant immunotoxins 347±379<br />
redox shuffling, immunotoxins 358<br />
refolding reaction, immunotoxins 358<br />
regression, of tumors 268<br />
renal cell cancers (RCC) 24, 86f., 100<br />
±, clinical trials 190<br />
±, HCV 239f.<br />
responses<br />
±, antibody see antibody responses<br />
±, antitumor see antitumor response<br />
±, autoimmune 232<br />
±, CTL see CTL responses<br />
±, immuno see immunoresponses<br />
±, T cell see T cell responses<br />
±, tumor antigen 209<br />
restin, antigen 20<br />
reverse immunology 43<br />
±, see also epitope deduction<br />
RFB4(dsFv)-PE38, immunotoxins 362<br />
RFT5-SMPT-dgA, immunotoxins 362<br />
rheumatoid arthritis 215<br />
ricin, immunotoxins 351f., 361<br />
Rituximab<br />
±, immunotoxins 367<br />
±, monoclonal antibody 277<br />
RNA, bacterial 268ff.<br />
RNA vaccination 187<br />
ROM see reactive oxygen metabolites<br />
Index<br />
s<br />
S100 staining, dendritic cells 182<br />
SAGE see serial analysis of gene expression<br />
saporin, immunotoxins 352<br />
scCRs see single-chain CRs<br />
scFcRs see single-chain FcRs<br />
scFvs see single-chain Fvs<br />
SCP-1 gene 24<br />
screening, antigen 19<br />
SCT see stem-cell transplantation<br />
second-generation immunotoxins 349f.<br />
±, see also recombinant immunotoxins<br />
selectivity, IL-10 production 162f.<br />
self-antigens 204, 207, 209<br />
±, definition 224<br />
±, immunocytokines 319<br />
self-tolerance 232<br />
SEREX see serological analysis of tumor<br />
antigens <strong>by</strong> recombinant cDNA expression<br />
cloning<br />
serial analysis of gene expression (SAGE)<br />
10f.<br />
serine-thronine kinase receptors 121<br />
serological analysis of tumor antigens <strong>by</strong><br />
recombinant cDNA expression cloning<br />
(SEREX) 18±25, 42, 232<br />
serological determinants, tumor cells 17±29<br />
shared antigens 256<br />
shed tumor antigens, immunosuppressive<br />
factors 120<br />
side effects, immunotoxins 361<br />
signal transducers <strong>and</strong> activation of<br />
transcription (STAT) 83ff.<br />
±, IL-10 157<br />
±, immunosuppressive factors 122f.<br />
significance<br />
±, clinical 23<br />
±, functional 24<br />
single-chain CRs (scCRs) 288±291<br />
single-chain FcRs (scFcRs) 288f.<br />
405
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