Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...

Fig. 6.1 Schematic representations of immune
responses to a pathogen (A), which presents a
danger signal or to a tumor (B), which presents
largely self-epitopes to the immune system and
6.3
Immune Cells in the Tumor Microenvironment
6.3 Immune Cells in the Tumor Microenvironment
also produces and releases iimmunoinhibitory
factors. In the absence of the ªdanger signalº a
weakimmune response is generated.
Pathologists have long ago called attention to the fact that human tumors are often
surrounded by as well as infiltrated with mononuclear cells [10, 11]. The role of tumor-infiltrating
lymphocytes (TIL) in tumor progression remains a highly controver-
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